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Analysis

1.115572716抗III型B群链球菌荚膜多糖单克隆抗体及杂交瘤细胞株
CN 06.01.2023
Int.Class C12N 5/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12Fused cells, e.g. hybridomas
16Animal cells
18Murine cells, e.g. mouse cells
20one of the fusion partners being a B lymphocyte
Appl.No 202211214570.1 Applicant 云南沃森生物技术股份有限公司 Inventor 黄镇
本发明公开了抗III型B群链球菌荚膜多糖单克隆抗体及杂交瘤细胞株。所述杂交瘤细胞株命名为WV‑GBSIII‑04,保藏编号:CCTCCNO:C202028,所述述单克隆抗体由所述杂交瘤细胞株分泌。本发明可用于B群链球菌荚膜多糖分型诊断以及B群链球菌疫苗和结合疫苗研发过程中III型B群链球菌荚膜多糖的定量检测,特异性强,检测灵敏度可达纳克级,提高了检测的灵敏度,且操作简单。
2.2022552875多様な固形腫瘍を処置するためのB7H3(CD276)を標的とする高親和性ナノボディ
JP 20.12.2022
Int.Class C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Appl.No 2022523456 Applicant ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ Inventor ホー, ミッチェル
B7H3(CD276としても公知)を特異的に結合する単一ドメインモノクローナル抗体が記載される。単一ドメイン抗体は、ファージディスプレイライブラリーから選択されるラクダVHおよびウサギVHドメインナノボディを含む。B7H3を標的とするキメラ抗原受容体(CAR)および他の抗体コンジュゲートも記載される。単一ドメイン抗体およびそのコンジュゲートは、B7H3を発現する固形腫瘍の診断および処置のために使用することができる。
3.115417916阿尔茨海默病中的TAU蛋白介导病变的基于蛋白质的疗法和诊断
CN 02.12.2022
Int.Class C07K 7/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
Appl.No 202210373330.X Applicant 阿克松神经系统科学公司 Inventor M.诺瓦克
本发明提供结合tau蛋白的有助于启始和扩散病理性tau蛋白‑tau蛋白相互作用的区域的独特治疗和诊断抗体以及它们的片段、部分、衍生物及其变体以及制备它们的方法。本发明也涉及使用那些抗体诊断、预防和治疗阿尔茨海默病和相关tau蛋白病变的方法。本发明也提供一种用于防治性和治疗性治疗阿尔茨海默病和其它神经变性tau蛋白病变的方法。这个方法需要注射会引发针对患者的脑中的病理性tau蛋白和tau蛋白沉积物的免疫反应的的抗体和/或肽疫苗。适合疫苗代表携带本文提供的一种或多种tau蛋白治疗表位的tau肽。
4.WO/2022/245553TREM-2/DAP-12 INHIBITORS FOR TREATING LUNG DISEASE AND INJURY AND COMBINATIONS THEREOF
WO 24.11.2022
Int.Class A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
Appl.No PCT/US2022/027836 Applicant SIGNABLK, INC. Inventor SIGALOV, Alexander
The present invention is related to the field of pulmonary therapeutics. In particular, the compositions described herein are used in methods of treating lung disease and injury including but not limited to acute respiratory distress syndrome (ARDS), CO VID infection, cytokine storms, sepsis and related conditions. These compositions include, but are not limited to, peptide variants and compositions that inhibit activity of a receptor complex formed by triggering receptors expressed on myeloid cells (TREM; i.e., TREM-1, TREM-2, TREM-3 or TREM-4) and DNAX activation protein of 12kDa (DAP 12).
5.WO/2022/246116ANTIBODY-BASED ANTIVIRUS COMPOSITIONS AND METHODS OF USE
WO 24.11.2022
Int.Class A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
Appl.No PCT/US2022/030114 Applicant ACHELOIS BIOPHARMA, INC. Inventor CHEN, Michael
Provided herein are antibody-based antiviruses comprising a fusion protein that comprises a transmembrane polypeptide and an antibody which binds to a surface protein of a virus, wherein the fusion protein is expressed at a valency of at least about 10 copies on a surface of the antivirus, and wherein the antibody neutralizes the virus when expressed within the fusion protein on the surface of the antivirus but does not neutralize the virus when expressed as an isolated antibody. Further provided herein are antibody-based antiviruses for treating a viral infection (e.g., SARS-CoV-2).
6.0002783666METHOD FOR EXTRACTION OF TOXOCARA CANIS LARVAE FROM EGGS FOR DIAGNOSTIC ANTIGEN PRODUCTION
RU 15.11.2022
Int.Class G01N 33/48
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
Appl.No 2022104696 Applicant Inventor Андреянов Олег Николаевич (RU)
FIELD: veterinary parasitology and biotechnology. SUBSTANCE: invention relates to the field of veterinary parasitology and biotechnology. A method is proposed for extraction Toxocara canis larvae from eggs for the production of a diagnostic antigen, which includes incubation of T. canis eggs in the bile of ruminants using a magnetic stirrer at 50 rpm with heating at a culture medium temperature of 39±1°C for 50 min. EFFECT: invention provides an extension of the arsenal of biotechnological methods for obtaining full-fledged viable toxocara larvae for obtaining a diagnostic antigen for intravital and post-mortem diagnosis of animal toxocariasis. 1 cl, 2 tbl, 2 ex
7.115317603抗体佐剂缀合物
CN 11.11.2022
Int.Class A61K 39/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
Appl.No 202210490449.5 Applicant 小利兰·斯坦福大学托管委员会 Inventor 迈克尔·纳撒尼尔·阿隆索
本发明提供了一种免疫缀合物,所述免疫缀合物包含:抗体构建体,所述抗体构建体包含抗原结合结构域和Fc结构域;佐剂部分;以及连接子,其中每个佐剂部分经由所述连接子与所述抗体共价结合。还描述了用本发明的所述免疫缀合物治疗癌症的方法。
8.WO/2022/224203ANTIBODIES THAT BIND SARS-COV-2 SPIKE PROTEIN
WO 27.10.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/IB2022/053756 Applicant NATIONAL RESEARCH COUNCIL OF CANADA Inventor TANHA, Jamshid
Described herein are antibodies that specifically recognize the SARS-CoV-2 spike (S) polypeptide,compositions comprising said antibodies, uses thereof, and methods employing said antibodies. Eachantibody specifically recognizes the S1-RBD domain, S1-NTD domain, or S2 subunit of the SARS-CoV-2 spike polypeptide. Some antibodies are cross-reactive with variants of SARS-CoV-2 and othercoronavirus spike polypeptides, such as SARS-CoV S, pangolin CoV S, bat SARS-like CoV S, andcivet SARS-CoV S.
9.0002785436ANTIBODIES AGAINST A5 REPRESENTATIVE OF 19 FAMILY WITH SIMILARITY OF SEQUENCES AND THEIR APPLICATION METHOD
RU 27.10.2022
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No 2021111987 Applicant НЬЮРЭКЛ САЙЕНС КО., ЛТД. (KR) Inventor КИМ, Понкчол (KR)
FIELD: biotechnology. SUBSTANCE: in the present invention, antibodies are presented, which specifically bind to human FAM19A5, as well as nucleic acid encoding an antibody, an expression vector, a cell for antibody expression, a composition for inhibition of FAM19A5 activity, a kit for inhibition of FAM19A5 activity, a method for the production of an antibody, which specifically binds to human FAM19A5 protein, and a method for the treatment of disorders, such as damage to the central nervous system, degenerative brain disease, or neuropathic pain, by administration of an antibody, which specifically binds to human FAM19A5. EFFECT: obtainment of an antibody against human FAM19A5. 37 cl, 25 dwg, 9 tbl, 12 ex
10.WO/2022/217359FUNCTIONALIZED BIOLOGICAL MEMBRANES WITH MODIFYING PROTEIN MOLECULES, AND METHODS OF MAKING AND USES THEREOF
WO 20.10.2022
Int.Class C07K 17/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
17Carrier-bound or immobilised peptides; Preparation thereof
02Peptides being immobilised on, or in, an organic carrier
Appl.No PCT/CA2022/050576 Applicant MCMASTER UNIVERSITY Inventor RHEINSTADTER, Maikel
Described herein is a functionalized biological membrane comprising an endogenous bilayer and one or more modifying protein molecules embedded therein or attached thereto. Also described herein is a method of preparing a functionalized biological membrane comprising one or more modifying protein molecules embedded therein or attached thereto, and methods of use and uses of said functionalized biological membranes.