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Analysis

1.WO/2023/002505ASSAY FOR DETECTION OF EPIDEMIOLOGICALLY IMPORTANT SARS- COV-2 VARIANTS
WO 26.01.2023
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/IN2022/050649 Applicant INDIAN COUNCIL OF MEDICAL RESEARCH Inventor NANDI, Shyam Sundar
The present invention relates to novel oligonucleotide sequences for rapid screening of epidemiologically important variants of SARS-CoV-2, wherein said oligonucleotide sequences acts as primers for amplification of sequences having Single-nucleotide polymorphisms (SNP)/mutations in the spike glycoprotein gene. The invention also relates to an assay for rapid screening of epidemiologically important variants of SARS-CoV-2 based upon using novel oligonucleotide sequences as primers. In particular, invention relates to oligonucleotide sequences of SEQ ID Nos. 1 – 37 for rapid screening of epidemiologically important variants of SARS-CoV-2.
2.WO/2023/002325COMPOSITIONS AND METHODS FOR CHARACTERIZING A COMPLEX BIOLOGICAL SAMPLE
WO 26.01.2023
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/IB2022/056558 Applicant THE BROAD INSTITUTE, INC. Inventor EARL, Ashlee M.
The invention features compositions and methods that are useful for characterizing a complex biological sample.
3.WO/2023/002120USE OF TORQUE TENO VIRUS (TTV) AS A MARKER TO DETERMINE THE RISK OF COMPLICATIONS IN A PATIENT ADMITTED TO A HEALTHCARE FACILITY
WO 26.01.2023
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/FR2022/051436 Applicant BIOMERIEUX Inventor MALLET, François
The present invention relates to a method for in vitro or ex vivo assessment of the risk of complications in a patient admitted to a healthcare facility, the method comprising measuring the viral load of at least one torque teno virus (TTV) in a biological sample of said patient, characterised in that said patient is not undergoing immunosuppressive treatment.
4.WO/2023/003608METHODS OF COLLECTING AND ANALYZING DUST SAMPLES FOR SURVEILLANCE OF VIRAL DISEASES
WO 26.01.2023
Int.Class C12Q 1/48
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
48involving transferase
Appl.No PCT/US2022/024483 Applicant OHIO STATE INNOVATION FOUNDATION Inventor DANNEMILLER, Karen
Described herein are methods for the detection of a virus (e.g., SARS-CoV-2) RNA in dust, which can be used for continued environmental surveillance of the viral disease. Targeted monitoring of dust in high-concern buildings can complement broader population-level monitoring approaches. Additionally, a method for detection of a viral RNA in a dust sample is disclosed herein.
5.WO/2023/004391NUCLEIC ACID DETECTION USING TYPE III CRISPR COMPLEX
WO 26.01.2023
Int.Class C12Q 1/6816
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
Appl.No PCT/US2022/074017 Applicant MONTANA STATE UNIVERSITY Inventor WIEDENHEFT, Blake, A.
The disclosure relates to engineered systems and methods for detecting target nucleic acid in a sample, which may be a complex mixture. The systems and methods may improve sensitivity of target nucleic acid detection by enhancing signal generation. For example, signal generation may be enhanced through programmable capture and concentration of the target nucleic acid using an engineered type III CRISPR complex. Various ancillary nucleases such as Can1, Can2, and NucC are identified and may be used for detection. For example, binding of the engineered type III CRISPR complex may produce products that activate the identified ancillary nucleases. Different activators trigger changes in the substrate specificity of these nucleases. The activated nucleases may be used to detect programmatic detection of the target nucleic in the sample. The systems and methods are shown to detect viral RNA directly from nasopharyngeal swab samples.
6.3125300UTILISATION DU VIRUS TORQUE TENO (TTV) EN TANT QUE MARQUEURS POUR DETERMINER LE RISQUE DE COMPLICATION CHEZ UN PATIENT ADMIS AU SEIN D’UN ETABLISSEMENT DE SANTE
FR 20.01.2023
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
Appl.No 2107771 Applicant BIOMERIEUX Inventor MALLET FRANÇOIS
La présente invention porte sur un procédé d’évaluation in vitro ou ex vivo du risque de complication chez un patient admis au sein d’un établissement de santé, comprenant la mesure de la charge virale d’au moins un torque teno virus (TTV) dans un échantillon biologique dudit patient, caractérisé en ce que ledit patient n’est pas sous traitement immunosuppresseur.
7.WO/2023/286095METHOD FOR DETECTING A TARGET GENOME
WO 19.01.2023
Int.Class C12Q 1/6816
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
Appl.No PCT/IT2022/050195 Applicant UNIVERSITA' DEGLI STUDI DI MESSINA Inventor CONOCI, Sabrina
The present invention relates to a method allowing a rapid and sensitive genome molecular detection, by the detection of nucleic acids thereof. Specifically, the method combines the cooperative hybridization process of a macromolecular genetic target on the electrode surface derivatized with an electrochemiluminescence (ECL)-based ultrasensitive detection. The method allows to directly detect a target genome without any amplification. Therefore, the method of the invention can be considered as an amplification-free approach, in particular a PCR-free approach.
8.WO/2023/287901DEVICES AND METHODS FOR EXTRACTION-FREE PATHOGEN TESTING
WO 19.01.2023
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/US2022/036993 Applicant SUMMIT BIOLABS, INC. Inventor BLOMQUIST, Robert, E.
The invention provides compositions, devices, methods and kits allowing for rapid diagnosis of infectious diseases, including viruses, such as influenza and SARS-CoV-2, via extraction-free, direct PCR techniques using combined biological samples, such as a saliva sample and respiratory mucosa sample in a buffer composition comprising nuclease-free water, an antifungal, an antibiotic, and a ribonuclease inhibitor.
9.WO/2023/287723METHODS FOR VIRAL PARTICLE CHARACTERIZATION USING TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
WO 19.01.2023
Int.Class G01N 30/46
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
38Flow patterns
46using more than one column
Appl.No PCT/US2022/036723 Applicant REGENERON PHARMACEUTICALS, INC. Inventor QIU, Haibo
Methods for identifying viral protein constituents and quantifying the relative abundance of such viral protein constituents in a sample of viral particles are disclosed. In embodiments, the methods include first-dimension chromatography to separate intact viral capsid components of the sample, online denaturation of the viral capsid components to produce intact viral proteins, second-dimension chromatography to separate the viral proteins, and mass spectrometry to determine the masses of the viral proteins and identify the viral protein constituents of the sample.
10.102021118418Verfahren zur Analyse und/oder Detektion von biologischen Strukturen
DE 19.01.2023
Int.Class G01N 33/533
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
532Production of labelled immunochemicals
533with fluorescent label
Appl.No 102021118418 Applicant Herbst Franz Inventor Erfinder gleich Anmelder

Die vorliegende Erfindung betrifft ein Verfahren zur Analyse und/oder Detektion von biologischen Strukturen. Das erfindungsgemäße Verfahren ist dadurch gekennzeichnet, dass in einem ersten Verfahrensschritt biologische Strukturen mittels fluoreszierenden Nanopartikeln markiert werden, die bei Anregung mit einer spezifischen Wellenlänge Licht einer definierten Wellenlänge emittieren, wobei die biologischen Strukturen zur Bildung von Struktur-Komplexen in einem zu analysierenden Gemisch verschiedener biologischer Strukturen aneinander gebunden werden, wobei die fluoreszierenden Nanopartikel aus Gruppen mit verschiedene Emissionsspektren gewählt werden und jeder Gruppe eine spezifischer biologische Struktur zugeordnet wird, wodurch die verschiedenen Strukturen im Gemisch über ihr Emissionsspektrum analysier- und/oder identifizierbar sind, wobei in einem zweiten Verfahrensschritt das Gemisch durch mindestens einen Filter und/oder in ein Filtermedium und/oder Trennmedium geleitet wird, dessen Porengröße oder Trenneigenschaften derart gewählt ist, dass die gebundenen und mittels den fluoreszierenden Nanopartikeln markierten Struktur-Komplexe an dem Filter und/oder in dem Filtermedium aufgehalten oder durch den Filter und/oder durch das Filtermedium und/oder Trennmedium aufgetrennt werden und die ungebundenen Strukturen durch den Filter und/oder durch das Filtermedium und/oder das Trennmedium laufen. embedded image