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1.WO/2023/003851COMPOSITIONS AND METHODS FOR IMPROVED 5-HYDROXYMETHYLATED CYTOSINE RESOLUTION IN NUCLEIC ACID SEQUENCING
WO 26.01.2023
Int.Class C12Q 1/6853
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6853using modified primers or templates
Appl.No PCT/US2022/037557 Applicant FREENOME HOLDINGS, INC. Inventor ARIAZI, Eric
The present disclosure provides oligonucleotide adapter compositions, methods, and systems for improved resolution of 5hmC sequencing useful for improving nucleic acid sequencing library quality and nucleic acid methylation profiling. Also provided are methods of applying the improved oligonucleotide adapters and sequencing methods for machine learning classifier generation, and detecting cell proliferative disorders such as cancer. Methods of applying targeted nucleic acid enrichment with methods of applying the improved oligonucleotide adapters and sequencing methods for improving nucleic acid sequencing library quality and nucleic acid methylation profiling are also provided.
2.4123031METHODS FOR DETECTING AGGLUTINATION AND COMPOSITIONS FOR USE IN PRACTICING THE SAME
EP 25.01.2023
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 22177391 Applicant UNIV CALIFORNIA Inventor ROBINSON PETER
Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotide s. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.
3.WO/2023/286629METHOD FOR PRODUCING PLASMID DNA USING ESCHERICHIA COLI
WO 19.01.2023
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No PCT/JP2022/026275 Applicant KANEKA CORPORATION Inventor TOKUNAGA Tomohisa
The purpose of the present invention is to collect plasmid DNA from a cell body of Escherichia coli with high efficiency in the production of the plasmid DNA using the Escherichia coli. Provided is a method for producing plasmid DNA, the method comprising the following steps (a) to (c): (a) preparing Escherichia coli that has a mutation in a gene region involved in the retention of the properties of an outer membrane thereof and carries a desired plasmid; (b) culturing the Escherichia coli prepared in the step (a); and (c) collecting the desired plasmid from the cultured cells.
4.WO/2023/283092COMPOSITIONS AND METHODS FOR EFFICIENT GENOME EDITING
WO 12.01.2023
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
Appl.No PCT/US2022/035613 Applicant PRIME MEDICINE, INC. Inventor REES, Holly A.
Provided herein are improved prime editing methods and compositions that allow for efficient and precise editing of target genes.
5.115584349一种基于酶促合成对RNA链中任意残进行特异性标记的方法
CN 10.01.2023
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No 202211251930.5 Applicant 中国科学院合肥物质科学研究院 Inventor 张钠
本发明公开一种基于酶促合成对RNA链中任意残进行特异性标记的方法,涉及核糖核酸链的合成与特殊标记技术领域,包括以下步骤:(1)引物链和不同长度模板链的设计;(2)酶促合成;(3)利用内切酶Endonuclease V和不耐热型碱性磷酸酶将目标RNA准确的从引物链上切割下来,然后对目标RNA进行分离纯化。本发明的有益效果在于:可以对RNA链中任意残基进行特异性标记的方法,可以对任意RNA(任意长度、任意序列)的任意残基(任意残基位置、任意残基类型)进行精准的标记。
6.WO/2023/273366NUCLEIC ACID LIGASE
WO 05.01.2023
Int.Class C12N 9/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
Appl.No PCT/CN2022/077538 Applicant WENZHOU MEDICAL UNIVERSITY Inventor DING, Chunming
Provided is a nucleic acid ligase, which comprises, compared with an existing amino acid sequence of Hyperligase (shown in SEQ ID NO: 1), an amino acid sequence having a mutation at one or more positions selected from among positions 79, 281, 370 and 372. Also provided are a nucleic acid molecule encoding the enzyme, a carrier containing the nucleic acid molecule, and a recombinant cell containing the nucleic acid molecule or the carrier. Also provided are a composition containing the enzyme and a use of the enzyme.
7.20230002799METHODS OF SYNTHESIZING MRNA AND FUNCTIONAL PROTEINS FROM SYNTHETIC DOUBLE STRANDED DNA
US 05.01.2023
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 17784816 Applicant Vanderbilt University Inventor John T. Tossberg

Disclosed are methods for preparing mRNA and proteins from synthetic DNA.

8.WO/2023/275217METHOD FOR RNA MANUFACTURING
WO 05.01.2023
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/EP2022/068012 Applicant ETHERNA IMMUNOTHERAPIES NV Inventor DILLEN, Senne
The present invention relates to the field of nucleic acid production, in particular in vitro RNA transcription. More specifically, the present invention relates to a method wherein physicochemical properties of the reaction mixture are monitored in order to timely stop the reaction and/or to add fresh reagents to allow the reaction to continue under optimal conditions. In particular, conductivity, but also pH and/or optical density is determined at at least two different time points, or continuously during the in vitro transcription reaction.
9.20230002758TETHERED RIBOSOMES AND METHODS OF MAKING AND USING THEREOF
US 05.01.2023
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No 17841618 Applicant Northwestern University Inventor Do Soon Kim

The present disclosure relates to methods to evolve macromolecular machines and improved macromolecular machines identified and made by the methods. In some embodiments, the improved macromolecular machines include improved tethered ribosomes. Also disclosed are systems and methods for making and using the improved tethered ribosomes.

10.20220411842METHOD FOR GENERATING REGION-SPECIFIC AMPLIFICATION TEMPLATES
US 29.12.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 17844780 Applicant LEICA MICROSYSTEMS CMS GMBH Inventor Falk SCHLAUDRAFF

A method for generating region-specific amplification templates of a biological sample includes adding first oligonucleotide constructs and second oligonucleotide constructs to the biological sample. Each first or second oligonucleotide construct comprises a first or a second photoremovable cage molecule. The method further includes synthesising a complementary first strand from a template bound to target binding regions of each first oligonucleotide construct or each second oligonucleotide construct, scanning a first region of interest of the biological sample with a first focused light beam and a second region of interest of the biological sample with a second focused light beam to form uncaged first oligonucleotide constructs in the first region of interest and uncaged second oligonucleotide constructs in the second region of interest, synthesising a complementary second strand to form first amplification templates originating from the first region of interest and second amplification templates originating from the second region of interest.