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Analysis

1.WO/2023/002372METHOD FOR THE PRODUCTION OF A SHAPE-MEMORY TISSUE AND RELATIVE USES
WO 26.01.2023
Int.Class D01D 5/00
DTEXTILES; PAPER
01NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
DMECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF MAN-MADE FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
5Formation of filaments, threads, or the like
Appl.No PCT/IB2022/056647 Applicant UNIVERSITA' DEGLI STUDI DI PAVIA Inventor GENTA, Ida
The present invention consists of a method for the production of a shape-memory tissue through the use of polymeric matrices capable of temporarily modifying their shape, following the application of an external stimulus, and at the same time capable of supporting the vehiculation of cells and/or drugs.
2.WO/2023/001481A SYSTEM FOR DISSOCIATION OF SOLID BIOPSY AND A METHOD FOR INSPECTION
WO 26.01.2023
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/EP2022/067156 Applicant MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. Inventor SOTERIOU, Despina
The present invention relates to System for analysing tissue, comprising: a dissociation means for at least partially dissociating a tissue sample so as to obtain individual cells, a microfluidic flow device through which a fluid comprising the dissociated cells can be made to flow, and an evaluation device arranged to evaluate the cells as they are being transported through the microfluidic flow device, the system preferably being arranged for a label free analysis of tissue.
3.WO/2023/001977METHOD FOR THE GENERATION OF DENDRITIC AND/OR BIOMIMETIC NETWORK STRUCTURES, NETWORK STRUCTURES, TISSUES AND APPLICATIONS THEREOF
WO 26.01.2023
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/EP2022/070531 Applicant TECHNISCHE UNIVERSITÄT DARMSTADT Inventor FRITSCHEN, Anna
The invention relates to methods for the generation of dendritic and/or biomimetic network structures using a printing process, as well as to network structures and tissues obtained therefrom and their applications on a laboratory scale and in the industrial field.
4.WO/2023/003254AGED-SKIN MODEL AND PRODUCTION METHOD THEREFOR
WO 26.01.2023
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
Appl.No PCT/KR2022/010175 Applicant INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY Inventor SUNG, Gun Yong
An aged-skin model has been produced by applying a mechanical stimulus driving system to a stretchable skin chip when a 3D full-thickness skin equivalent is cultured using human fibroblasts and keratinocytes. Accelerated aging due to periodic compressive stress has been validated through results such as those of a decrease in the thickness of the epidermal layer, a decrease in the shrinkage rate of a full-thickness skin equivalent, an increase in the expression of a β-galactosidase gene, an increase in the secretion of a reactive oxygen species and TGF-β1, and a decrease in the secretion of Myb. An in-vitro aged-skin model produced by the application of a stretchable skin chip and a mechanical stimulus driving system can contribute to the cosmetics industry in which animal testing is prohibited and to the reduction of development time of new drugs for skin diseases.
5.WO/2023/000901METHOD AND DEVICE FOR POWER DISTRIBUTION IN CARBON DIOXIDE INCUBATOR, AND CARBON DIOXIDE INCUBATOR
WO 26.01.2023
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/CN2022/100136 Applicant QINGDAO HAIER BIOMEDICAL TECHNOLOGY CO., LTD. Inventor CHEN, Huan
A method for power distribution in a carbon dioxide incubator, a device for power distribution in a carbon dioxide incubator, and a carbon dioxide incubator. The method comprises: obtaining a power index according to the current temperature and a target temperature in an incubator; by means of the power index, obtaining a heating policy for each inner surface of the carbon dioxide incubator; and, according to the policy, adjusting the power and/or start/stop time of a heating wire on each inner surface. Thus, the heating wire on each inner surface of the carbon dioxide incubator can be separately controlled, preventing condensation in the carbon dioxide incubator. In the described method, heating wires are controlled without calculation using multiple sets of control algorithms, reducing algorithm redundancy, improving control efficiency, and saving system resources.
6.WO/2023/001831CELL CULTURE DEVICE AND MOVEMENT SYSTEM
WO 26.01.2023
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
Appl.No PCT/EP2022/070215 Applicant UNIVERSITETET I OSLO Inventor KRAUSS, Stefan Johannes Karl
A cell culture apparatus comprises a cell culture device (10) and a movement system (12) for moving the cell culture device (10). The cell culture device (10) comprises: at least two reservoirs (4) for holding a liquid cell medium, one or more chambers (6) for culturing of living cells, tissues or living organoids and at least two perfusion channels (8) connecting the reservoirs (4). The one or more chambers (6) are separated from at least one of the perfusion channels (8) by a semipermeable barrier (16) for selective transport of cell media and/or for selective growth or migration of living cells. The reservoirs (4) and perfusion channels (8) are in fluid communication with one another in order to form a flow loop having a flow path for a one-way gravity-driven flow of the liquid cell medium when the cell culture device (10) is tilted and moved by the movement system (12). A movement axis (20) is defined as an axis (20) of the cell culture device (10) that passes through the cell culture device (10) with the flow loop being located around the movement axis (20). The movement system (12) is configured to move the cell culture device (10) with the movement axis (20) in a tilted orientation in order to move the lowest point of the flow loop through all points within the flow path of the flow loop and thereby generate gravity driven circulation of the liquid cell medium around the flow loop, wherein the tilted orientation places the movement axis at an angle in the range 5° to 85° away from the vertical.
7.WO/2023/003046CULTURE SYSTEM
WO 26.01.2023
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2022/028554 Applicant SAGA UNIVERSITY Inventor NAKAYAMA Koichi
A culture system that comprises: a support for stacking cell aggregates, said support being provided with needle-shaped parts that are arranged on a substrate like a kenzan (flower frog needles), in which the outermost needle-shaped parts on the substrate are arranged so that the distance from the needle-shaped parts to the outer edge of the substrate is shorter than the distance between adjacent needle-shaped parts; a culture tank for housing a culture unit in which cell aggregates are stacked on the support; a liquid culture medium container; and a plurality of liquid culture medium supply pipes that supply a liquid culture medium from the liquid culture medium container to the culture unit, wherein each of the plurality of liquid culture medium supply pipes is positioned between the needle-shaped part.
8.WO/2023/000590AUXILIARY ASSEMBLY AND DISASSEMBLY MECHANISM OF CELL PHENOTYPE CONTROL APPARATUS AND ASSEMBLY AND DISASSEMBLY SYSTEM
WO 26.01.2023
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/CN2021/138002 Applicant SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY Inventor WANG, Lei
An auxiliary assembly and disassembly mechanism (100) of a cell phenotype control apparatus and an assembly and disassembly system, the auxiliary assembly and disassembly mechanism comprising: a support seat (101), which is disposed in a transverse direction; a placement platform (102), which is connected to the support seat (101) by means of a longitudinally extendable and retractable elastic member (106) and which is used for the placement of a cell phenotype control apparatus; at least one lever assembly (103), which are pivotally connected to the support seat (101) so as to form a fulcrum (107), the lever assembly (103) pivoting about the fulcrum (107) to clamp or loosen a light source control box (300) on the placement platform (102); a trigger member (104), which is configured to drive, when pressed down by the placement platform (102), the lever assembly (103) to pivot in the direction of clamping the light source control box (300); and a locking member (105), which is connected to the support seat (101) and which is configured to releasably lock the trigger member (104) when the lever assembly (103) clamps the light source control box (300), and the lever assembly (103) loosens the light source control box (300) after the locking member (105) releases the trigger member. The automatic disassembly of a cell culture plate of the cell phenotype control apparatus is achieved, manual operation by experiment personnel is not required, and experimental efficiency is improved.
9.WO/2023/001910SYSTEM AND METHOD FOR CELL PROCESSING
WO 26.01.2023
Int.Class C12M 1/36
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
Appl.No PCT/EP2022/070400 Applicant CELLUNITE GMBH Inventor KESHMIRI, Armin
The present invention is directed to a system, method, use, diagnostic kit for cell derived processing. The invention comprises a controlling component (41); and a driving and/or heating component (50) configured to host a cartridge (60) and to drive and/or heat the cartridge (60).
10.WO/2023/000638NOVEL INTEGRATED MICROARRAY BIOCHIP
WO 26.01.2023
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/CN2022/073753 Applicant ACCURATE INTERNATIONAL BIOTECHNOLOGY (GUANGZHOU) CO., LTD. Inventor QIU, Pei
The present utility model provides a novel integrated microarray biochip, comprising at least one chip and a carrier used for fixing and loading the chip. The chip comprises a chip main body and a bottom plate mounted at the bottom of the chip main body; the chip main body is provided with a plurality of micropores and a water tank; the water tank surrounds all the micropores. The integrated microarray biochip of the present utility model has advantages such as high analysis speed, low reagent consumption, easiness in integration, and high-throughput analysis, can overcome limitation of high-throughput drug screening, can be configured to be matched with a standard microwell plate such as a 384-well plate or a 1536-well plate in specification so as to adapt to a wide conventional test device, and has a low access threshold. Moreover, the microarray biochip can be suitable for different scene requirements by forming 2D cells or 3D organs having different condensation densities, and a multi-dimensional research platform is provided for cell-based high-throughput drug screening, tissue engineering, and biosensors.