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Analysis

1.WO/2023/001234MODIFIED SMALL INTERFERING RNA MOLECULES WITH REDUCED OFF-TARGET EFFECTS
WO 26.01.2023
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No PCT/CN2022/107028 Applicant MICROBIO (SHANGHAI) CO., LTD. Inventor CHANG, Yi-Chung
A modified small interfering RNA (siRNA) molecule comprising phosphorothioate (PS) intemucleotide linkages in the antisense strand for reducing off-target effects and methods and uses thereof. The siRNAs targeting Hypoxia Inducible Factor 1 Subunit Alpha (HIFla) with high specificity and silencing efficiency.
2.4122943OLIGONUCLEOTIDES COMPRISING A PHOSPHOROTRITHIOATE INTERNUCLEOSIDE LINKAGE
EP 25.01.2023
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No 22174461 Applicant ROCHE INNOVATION CT COPENHAGEN AS Inventor BLEICHER KONRAD
The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I)wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.
3.WO/2023/288204DIAGNOSTICS FOR PORPHYROMONAS GINGIVALIS
WO 19.01.2023
Int.Class G01N 33/554
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
554the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
Appl.No PCT/US2022/073614 Applicant KEYSTONE BIO, INC. Inventor NARA, Peter L.
Antigen-binding molecules (ABMs) that bind to Porphyromonas gingivalis are described. The ABMs may be human or humanized ABMs. The ABMs find use in treating infections involving P. gingivalis, such as periodontal disease. Also provided are methods of treating or preventing a disorder or disease by administering the ABM.
4.20230011179NUCLEOSIDE DERIVATIVE AND USE THEREOF
US 12.01.2023
Int.Class C07H 19/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
Appl.No 17771089 Applicant National University Corporation Tokai National Higher Education and Research System Inventor Yoshihito Ueno

Provided is a nucleoside derivative represented by the following formula (1):

embedded image

or a salt thereof,

  • wherein R1 represents an alkoxy group, a hydrogen atom or a halogen atom; R2 and R4, which may be the same as or different from each other, each represents a hydrogen atom, a protective group for a hydroxyl group, a phosphate group, a protected phosphate group, or —P(═O)nR5R6 in which n represents 0 or 1, R5 and R6, which may be the same as or different from each other, each represents a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, an alkoxy group, a cyanoalkoxy group, an amino group, or a substituted amino group, provided that when n is 1, both R5 and R6 cannot be the hydrogen atom at the same time; R3 represents —(CH2)mNHR7 in which m represents an integer of 1 to 6, R7 represents a hydrogen atom, an alkyl group, an alkenyl group or a protective group for an amino group; and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group, or a substituted 2-oxo-pyrimidin-1-yl group.

5.WO/2023/282245METHOD FOR PURIFYING NUCLEOTIDES, DEVICE FOR PURIFYING NUCLEOTIDES, HYDROPHOBIC REAGENT, AND HYDROPHOBIC SUBSTRATE
WO 12.01.2023
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Appl.No PCT/JP2022/026665 Applicant JAPAN SCIENCE AND TECHNOLOGY AGENCY Inventor ABE Hiroshi
The present invention is a method for purifying nucleotides, the method comprising: a protective group introduction step in which a hydrophobic protective group represented by formula (P1) or (P2) is introduced into nucleotides to generate hydrophobic nucleotides; an isolation/purification step in which the hydrophobic nucleotides are isolated/purified in a hydrophobic environment; and a deprotection step in which the hydrophobic protective group is deprotected from the hydrophobic nucleotides to generate nucleotides. (R1 represents C1-30 straight chain or branched chain alkyl group; R4 represents hydrogen, a C1-10 straight chain or branched chain alkyl group; R2, R3, R5 and R6 represent hydrogen, a C1-10 straight chain or a branched chain alkyl group, etc., and may be the same or different; and "*" represents a bond with nucleotides.)
6.WO/2023/283552METHODS OF PLACING LOCKED NUCLEIC ACIDS IN SMALL INTERFERING RNA STRANDS
WO 12.01.2023
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No PCT/US2022/073432 Applicant SWITCH THERAPEUTICS INC. Inventor HAN, Si-ping
Provided herein include methods, systems, and compositions for placing locked nucleic acids in small interfering RNA (siRNA) strands, for example conditionally activatable siRNA sensor strands, as well as the siRNA complexes generated using the method herein described and the component strands. The siRNA complex can be conditionally activated upon a complementary binding to an input nucleic acid strand (e.g. a mRNA of a biomarker gene specific to a target cell) through a sequence in a sensor nucleic acid strand of the nucleic acid complex. The activated nucleic acid complex can release a RNAi duplex which can specifically inhibit a target RNA.
7.WO/2023/283342OLIGONUCLEOTIDES AND VIRAL UNTRANSLATED REGION (UTR) FOR INCREASING EXPRESSION OF TARGET GENES AND PROTEINS
WO 12.01.2023
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2022/036367 Applicant TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION Inventor HU, Wenhui
A novel, small (21-mer oligonucleotide) and unique cz's-regulatory coding motif can greatly enhance the production of a variety of different types of proteins ranging from viral transcripts/proteins, endogenous gene products, vaccines, antibodies to engineered recombinant proteins in mammalian cells. The combination of novel peptide tag(s) having specified short amino acid sequences or derivatives thereof and the untranslated region (UTR) of viruses (snUTR) enhanced production of tagged proteins, including viral transcripts/proteins, endogenous gene products, vaccine, antibody, engineered recombinant proteins in a cell both in vitro, ex vivo and in vivo.
8.WO/2023/283642PAN-HUMAN CORONAVIRUS CONCATEMERIC VACCINES
WO 12.01.2023
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2022/073564 Applicant MODERNATX, INC. Inventor STEWART-JONES, Guillaume
The disclosure relates to pan-human coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
9.WO/2023/283434AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE BIOCONJUGATION APPROACH
WO 12.01.2023
Int.Class C07H 5/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
5Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
04to nitrogen
06Aminosugars
Appl.No PCT/US2022/036538 Applicant ALNYLAM PHARMACEUTICALS, INC. Inventor MANOHARAN, Muthiah
The present disclosure relates generally to monomers and methods for conjugating one or more ligands to oligonucleotides.
10.WO/2023/280934CAP ANALOG FOR THE 5'-END OF EUKARYOTIC MESSENGER RNAS
WO 12.01.2023
Int.Class C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Appl.No PCT/EP2022/068773 Applicant WESTFÄLISCHE WILHELMS-UNIVERSITÄT Inventor KLÖCKER, Nils
The present invention relates to a 5'-cap analog according to formula (I) or salts thereof, wherein the 5'-cap analog comprises a photocleavable group fused via a carbamate moiety to the 5'-cap structure.