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Analysis

1.WO/2023/002492CODON OPTIMIZATION OF NUCLEIC ACIDS
WO 26.01.2023
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/IL2022/050794 Applicant YEDA RESEARCH AND DEVELOPMENT CO. LTD. Inventor PILPEL, Yitzhak
A method of codon optimizing the sequence of a nucleic acid encoding a protein of a vaccine, comprising: (a) identifying synonymous codons for an amino acid at a predetermined position of the protein, wherein said predetermined position is a mutation site of a variant of the protein; and (b) selecting the synonymous codon that has a likelihood above a predetermined level to mis-incorporate the mutated amino acid at the predetermined position.
2.WO/2023/003332PLANT-BASED COVID-19 VARIANT RECOMBINANT SPIKE PROTEIN EXPRESSION VECTOR AND RECOMBINANT PROTEIN USING SAME
WO 26.01.2023
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Appl.No PCT/KR2022/010552 Applicant BIOAPPLICATIONS INC. Inventor SOHN, Eun-Ju
The present invention relates to a plant-based COVID-19 variant recombinant spike protein expression vector, and a recombinant protein using the expression vector, wherein a plant expression system is used such that the recombinant protein does not have the disadvantages of animal-derived recombinant proteins and exhibits an excellent SARS coronavirus 2 prevention and treatment effect, and thus can be effectively utilized as a safe composition for preventing and treating COVID-19.
3.WO/2023/002433COMPOSITIONS AND VACCINES FOR TREATING AND/OR PREVENTING CORONAVIRUS VARIANT INFECTIONS AND METHODS OF USING THE SAME
WO 26.01.2023
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/IB2022/056759 Applicant ENGENEIC MOLECULAR DELIVERY PTY LTD Inventor BRAHMBHATT, Himanshu
The present disclosure is directed to compositions and methods useful for treating, as well as vaccinating against, SARS-CoV-2 viral infections, including SARS-CoV-2 variant viral infections.
4.WO/2023/000403SARS-COV-2 SUBPROTEIN NANO-VACCINE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
WO 26.01.2023
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/CN2021/111511 Applicant WUHAN SHENGRUN BIOTECHNOLOGY CO., LTD. Inventor ZHENG, Junwu
A Sars-Cov-2 subprotein nano-vaccine, and a preparation method therefor and an application thereof. The nano-vaccine comprises: an organic compound self-assembled from polylactic acid, porphyrin, or a porphyrin derivative, and a Co2+ ion conjugate; Sars-Cov-2 antigen protein; a vaccine adjuvant; and a lipid. The synthetic organic compound has an adjuvant encapsulated in its core and a Sars-Cov-2 antigen protein efficiently loaded on the surface, such that a nano-vaccine system allowing for co-delivery of the Sars-Cov-2 antigen protein and vaccine adjuvant is realized, thereby maximizing the immunogenicity of the Sars-Cov-2 recombinant subprotein and enabling tracking the distribution of the subprotein in an organism by means of fluorescent molecules. In addition, the nano-vaccine is also linked with a polypeptide that can specifically target antigen-presenting cells, so as to promote the uptake of the nano-vaccine by DC cells and promote anti-viral response. The preparation method is simple and efficient and provides a way for effectively preventing Sars-Cov-2 infection.
5.WO/2023/001259PREPARATION AND APPLICATION OF RECOMBINANT MULTIVALENT NOVEL CORONAVIRUS TRIMER PROTEIN VACCINE CAPABLE OF INDUCING BROAD-SPECTRUM AND NEUTRALIZING ACTIVITY
WO 26.01.2023
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/CN2022/107213 Applicant SINOCELLTECH LTD Inventor XIE, Liangzhi
A recombinant multivalent novel coronavirus trimer protein vaccine capable of inducing broad-spectrum and neutralizing activity. The recombinant protein component comprises, but is not limited to, a homotrimer protein formed by introducing, into an extracellular domain (ECD) of B.1.617.1 strain and B.1.617.2 strain spike (S) proteins, a mutation site and a trimerization assistance structure. The multivalent vaccine comprises an ECD trimer protein of a single component or any combination of components of the variant strains above, and a pharmaceutically acceptable adjuvant. The vaccine combination shows excellent immunogenicity in mice, and can maintain long-term humoral immunity and cellular immunity. The multivalent novel coronavirus trimer protein vaccine can be used for preventing infection-related diseases caused by infection of novel coronavirus and variant strains thereof.
6.WO/2023/002505ASSAY FOR DETECTION OF EPIDEMIOLOGICALLY IMPORTANT SARS- COV-2 VARIANTS
WO 26.01.2023
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/IN2022/050649 Applicant INDIAN COUNCIL OF MEDICAL RESEARCH Inventor NANDI, Shyam Sundar
The present invention relates to novel oligonucleotide sequences for rapid screening of epidemiologically important variants of SARS-CoV-2, wherein said oligonucleotide sequences acts as primers for amplification of sequences having Single-nucleotide polymorphisms (SNP)/mutations in the spike glycoprotein gene. The invention also relates to an assay for rapid screening of epidemiologically important variants of SARS-CoV-2 based upon using novel oligonucleotide sequences as primers. In particular, invention relates to oligonucleotide sequences of SEQ ID Nos. 1 – 37 for rapid screening of epidemiologically important variants of SARS-CoV-2.
7.WO/2023/004415SARS-COV-2 VACCINE USING BACTERIAL SPORES EXPRESSING ANTIGENIC FRAGMENTS
WO 26.01.2023
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2022/074048 Applicant UNIVERSITY OF MIAMI Inventor MIRSAEIDI, Mehdi
Disclosed are compositions comprising a SARS-CoV-2 vaccine that can be administered orally. The vaccine can be on a platform comprising a spore coat protein from a spore forming bacteria, such as Bacillus subtilis. Also disclosed are methods of preventing or treating a COVID-19 infection comprising providing the SARS-CoV-2 vaccine to a subject.
8.WO/2023/003911MUCOSAL VACCINES FOR CORONAVIRUS DISEASES
WO 26.01.2023
Int.Class C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Appl.No PCT/US2022/037639 Applicant LOMA LINDA UNIVERSITY Inventor LANGRIDGE, William
Compositions and methods of reducing incidence or severity of a coronavirus disease in an animal by administering, via a mucosal route, a fusion protein containing a multimeric cholera toxin B subunit and an immunogenic peptide from a coronavirus.
9.4122492USE OF INACTIVATED NONREPLICATING MODIFIED VACCINIA VIRUS ANKARA (MVA)AS MONOIMMUNOTHERAPY OR IN COMBINATION WITH IMMUNE CHECKPOINT BLOCKING AGENTS FOR SOLID TUMORS
EP 25.01.2023
Int.Class A61K 39/285
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
275Poxviridae, e.g. avipoxvirus
285Vaccinia virus or variola virus
Appl.No 22180849 Applicant MEMORIAL SLOAN KETTERING CANCER CENTER Inventor DENG LIANG
The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.
10.4122478COMPOSITIONS AND METHODS OF USING STAT1/3 INHIBITORS WITH ONCOLYTIC HERPES VIRUS
EP 25.01.2023
Int.Class A61K 35/76
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
Appl.No 22180454 Applicant VIROGIN BIOTECH CANADA LTD Inventor JIA WILLIAM
The present disclosure relates to the use of an oncolytic virus, such as HSV, and a STAT1/3 inhibitor, such as nifuroxazide and C16, in the treatment of cancer. Therapeutic compositions are provided that may be used to prevent, treat, or ameliorate the effects of a targeted cancer. Methods of using such compositions are also disclosed, such as methods of using the therapeutic compositions for improving efficacy of an oncolytic virotherapy (and for preventing macrophage and microglia inhibition of oncolytic viral activity).