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Analysis

1.WO/2023/002492CODON OPTIMIZATION OF NUCLEIC ACIDS
WO 26.01.2023
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/IL2022/050794 Applicant YEDA RESEARCH AND DEVELOPMENT CO. LTD. Inventor PILPEL, Yitzhak
A method of codon optimizing the sequence of a nucleic acid encoding a protein of a vaccine, comprising: (a) identifying synonymous codons for an amino acid at a predetermined position of the protein, wherein said predetermined position is a mutation site of a variant of the protein; and (b) selecting the synonymous codon that has a likelihood above a predetermined level to mis-incorporate the mutated amino acid at the predetermined position.
2.WO/2023/003332PLANT-BASED COVID-19 VARIANT RECOMBINANT SPIKE PROTEIN EXPRESSION VECTOR AND RECOMBINANT PROTEIN USING SAME
WO 26.01.2023
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Appl.No PCT/KR2022/010552 Applicant BIOAPPLICATIONS INC. Inventor SOHN, Eun-Ju
The present invention relates to a plant-based COVID-19 variant recombinant spike protein expression vector, and a recombinant protein using the expression vector, wherein a plant expression system is used such that the recombinant protein does not have the disadvantages of animal-derived recombinant proteins and exhibits an excellent SARS coronavirus 2 prevention and treatment effect, and thus can be effectively utilized as a safe composition for preventing and treating COVID-19.
3.WO/2023/004307T CELL EPITOPES AND RELATED COMPOSITIONS USEFUL IN THE PREVENTION AND TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
WO 26.01.2023
Int.Class C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Appl.No PCT/US2022/073881 Applicant EPIVAX, INC. Inventor DE GROOT, Anne
The present disclosure generally relates to novel epitope-based compositions, including vaccines, against respiratory syncytial virus (RSV) infection and diseases caused by RSV. The disclosure relates to immunogenic polypeptides and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules. The compositions are particularly suited to produce vaccines, particularly for vaccinating against RSV infection and related diseases caused by RSV.
4.WO/2023/001248PHARMACEUTICAL COMPOSITION CONTAINING ANTI-TROP2 ANTIBODY DRUG CONJUGATE AND ITS APPLICATION
WO 26.01.2023
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/CN2022/107134 Applicant JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. Inventor MO, Xiyele
The disclosure relates to a pharmaceutical composition containing an anti-TROP2 antibody drug conjugate and its application. Specifically, the disclosure relates to a pharmaceutical composition comprising an antibody drug conjugate in a buffer. The pharmaceutical composition has good stability.
5.WO/2023/002433COMPOSITIONS AND VACCINES FOR TREATING AND/OR PREVENTING CORONAVIRUS VARIANT INFECTIONS AND METHODS OF USING THE SAME
WO 26.01.2023
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/IB2022/056759 Applicant ENGENEIC MOLECULAR DELIVERY PTY LTD Inventor BRAHMBHATT, Himanshu
The present disclosure is directed to compositions and methods useful for treating, as well as vaccinating against, SARS-CoV-2 viral infections, including SARS-CoV-2 variant viral infections.
6.WO/2023/001257ANTI-SUPPRESSION OF TUMORIGENICITY 2 ANTIBODY AND LIQUID COMPOSITION CONTAINING SAME
WO 26.01.2023
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/CN2022/107198 Applicant MABWELL (SHANGHAI) BIOSCIENCE CO., LTD. Inventor ZHANG, Yanzhen
An anti-suppression of tumorigenicity 2 (ST2) antibody or a fragment thereof. The anti-ST2 antibody or the fragment thereof can block the binding of IL-33 to a ST2 protein, and inhibit a downstream signaling pathway thereof, thereby exerting a therapeutic effect in diseases associated with IL-33/ST2 signaling pathway activation. In addition, a stable liquid antibody preparation containing the anti-ST2 antibody or the fragment thereof is further provided.
7.WO/2023/004287COMBINATION OF CHECKPOINT INHIBITORS AND AN ONCOLYTIC VIRUS FOR TREATING CANCER
WO 26.01.2023
Int.Class A61K 35/768
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
768Oncolytic viruses not provided for in groups A61K35/761-A61K35/76697
Appl.No PCT/US2022/073845 Applicant REGENERON PHARMACEUTICALS, INC. Inventor DADI-MEHMETAJ, Saida
This disclosure relates to novel triple combination therapies of an oncolytic virus, a PD-1 pathway inhibitor, and a CTLA4 inhibitor for treating or inhibiting the growth of a tumor in a patient with cancer.
8.WO/2023/001303PHARMACEUTICAL COMPOSITION AND USE
WO 26.01.2023
Int.Class C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Appl.No PCT/CN2022/107522 Applicant AKESO BIOPHARMA, INC Inventor WANG, Zhongmin
A pharmaceutical composition comprising an anti-TIGIT antibody or an antigen-binding fragment thereof, and an anti-CTLA4-anti-PD-1 bispecific antibody or an antigen-binding fragment thereof. Specifically, a heavy chain variable region of the antibody contains HCDR1-HCDR3 having amino acid sequences as shown in SEQ ID NOs: 3-5, respectively, and a light chain variable region contains LCDR1-LCDR3 having amino acid sequences as shown in SEQ ID NOs: 8-10, respectively.
9.WO/2023/001258PHARMACEUTICAL USE OF ANTI-TUMOR INHIBIN 2 ANTIBODY
WO 26.01.2023
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/CN2022/107205 Applicant MABWELL (SHANGHAI) BIOSCIENCE CO., LTD. Inventor ZHENG, Bin
Provided is the use of a new anti-tumor inhibin 2 (ST2) antibody in the preparation of a drug for preventing or treating inflammatory, allergic or autoimmune diseases. The anti-ST2 antibody can bind to human ST2 with a high affinity, and can block the binding of human ST2 and human IL-33, thereby being capable of effectively inhibiting IL-33/ST2 signaling pathways. The anti-ST2 antibody has the effects of positively preventing and treating inflammatory, allergic or autoimmune diseases.
10.WO/2023/004348ENGINEERED COMPOSITIONS FOR BONE-TARGETED THERAPY
WO 26.01.2023
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/US2022/073940 Applicant WILLIAM MARSH RICE UNIVERSITY Inventor XIAO, Han
The present disclosure provides methods for treating bone disease, such as bone cancers or bone metastasis of cancers, by administering an engineered bone-targeting compositions, such as an antibody or one or more polypeptides, such as an antibody or polypeptide engineered to comprise bone-homing peptide(s). Further provided herein are bone-targeting compositions, such as an antibody or one or more polypeptides, such as an antibody or polypeptide engineered to comprise bone-homing peptide(s).