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Analysis

1.20220205056PHAGE TEST KIT
US 30.06.2022
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 17603789 Applicant DSM IP Assets B.V. Inventor Paulus Petrus DE WAAL

The present invention relates to a kit suitable for detection and quantification of phage DNA from a lactic acid bacteria infecting phage in a dairy sample. The invention provides a quantitative polymerase chain reaction (qPCR) kit for detection and quantification of phage DNA to from a lactic acid bacteria infecting phage in a dairy sample, said kit comprising a first primer pair and wherein said first primer pair has a robustness of a delta Cq lower than 1.0 cycle when tested in a temperature range of 55.0-70.0, preferably 55.0-68.0, more preferably 58.6-65.6 degrees Celsius and wherein said first primer pair is directed to a lactic acid bacteria infecting phage which is a lactococcal phage from the subgroup 9362, c2 or P335 or a streptococcal phage from the subgroup pac.

2.WO/2022/140616TAXONOMY-INDEPENDENT CANCER DIAGNOSTICS AND CLASSIFICATION USING MICROBIAL NUCLEIC ACIDS AND SOMATIC MUTATIONS
WO 30.06.2022
Int.Class G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Appl.No PCT/US2021/064977 Applicant MICRONOMA, INC. Inventor WANDRO, Stephen
Provided are systems and methods for the diagnosis and classification of cancer by taxonomy-independent classifications of microbial nucleic acids and somatic mutations.
3.WO/2022/139886CRISPR ENZYME CIRCUITS FOR MOLECULAR ELECTRONIC SENSORS
WO 30.06.2022
Int.Class C12Q 1/6834
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
Appl.No PCT/US2021/046581 Applicant ROSWELL BIOTECHNOLOGIES, INC. Inventor MERRIMAN, Barry
In various embodiments of the present disclosure, a molecular electronics sensor comprising a CRISPR Cas enzyme/crRNA complex is described. The CRISPR Cas enzyme/crRNA molecular electronics sensor may be one of a plurality of such sensors configured in a sensor array on a CMOS chip. The sensor array chip is capable of detecting nucleic acid targets hybridizing with the crRNA and/or complexing with the CRISPR Cas enzyme in the individual sensor pixels, wherein molecular interactions and/or Cas enzyme activity are seen as perturbations in a measured electrical parameter of the sensor circuits, such as signals or a signature of signals in a current versus time trace.
4.WO/2022/140126DNA VECTOR AND USES THEREOF FOR DETECTING HIV AND SIV
WO 30.06.2022
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
Appl.No PCT/US2021/063514 Applicant THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Inventor BRENCHLEY, Jason Michael
The present invention relates to a vector and its use as a standard in methods for detecting HIV and SIV.
5.WO/2022/139270SARS-COV-2 PACKAGED RNA REFERENCE MATERIAL FOR COVID-19 VIRUS DIAGNOSIS, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO 30.06.2022
Int.Class C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Appl.No PCT/KR2021/018650 Applicant KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE Inventor YOO, Hee Min
The present invention relates to a SARS-CoV-2 packaged RNA reference material for COVID-19 virus diagnosis and a preparation method therefor. In addition, the present invention relates to a method for providing information about whether there is COVID-19 infection, by using the SARS-CoV-2 packaged RNA reference material. The SARS-CoV-2 packaged RNA reference material, the preparation method therefor, and the method for providing information about whether there is COVID-19 infection, by using the SARS-CoV-2 packaged RNA reference material can find a wide spectrum of applications in the COVID-19 diagnosis field. Moreover, being identified to have a between-bottle homogeneity of k=95% and exhibit long-term storage and stability by itself, the COVID-19 virus reference material enjoys the advantage of reducing false-positive determination and improving reliability.
6.WO/2022/140274NOVEL ENTEROVIRUS 71 MUTATIONS ASSOCIATED WITH DISEASE SEVERITY
WO 30.06.2022
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/US2021/064392 Applicant SHIH, Chiaho Inventor SHIH, Chiaho
A method of detecting severe disease-associated mutations in an enterovirus 71 (EV- A71), comprising: performing an assay on a test sample containing an EV-A71 genomic RNA, a fragment thereof or an amplicon thereof, or an EV-A71 VP1 protein or fragment thereof to detect one or more severe disease-associated mutations in the EV-A71 genomic RNA, the fragment thereof or the amplicon thereof, or the EV-A71 protein or fragment thereof, wherein the one or more mutations are selected from mutations at positions corresponding to 5' UTR nucleotide positions C580, A707, and C709 in an EV-A71 5' UTR nucleic acid sequence and at residues corresponding to A280 and E145 in an EV-A71 VP1 protein sequence.
7.WO/2022/135139NUCLEIC ACID CONSTRUCT FOR AIDS GENE THERAPY
WO 30.06.2022
Int.Class C12N 15/63
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Appl.No PCT/CN2021/136153 Applicant KANGLIN BIOTECHNOLOGY (HANGZHOU) CO., LTD Inventor WU, Haoquan
Provided is a nucleic acid construct for AIDS gene therapy. The nucleic acid construct comprises multiple polynucleotides encoding single chain variable region fragments of an anti-AIDS neutralizing antibody, and polynucleotides encoding immunoglobulin Fc fragments; the single chain variable region fragments of the anti-AIDS neutralizing antibody comprise a single chain variable region fragment capable of specifically binding to HIV, and a single chain variable region fragment capable of specifically binding to a CD4 receptor. The construct can be used for gene therapy of AIDS caused by HIV infection, and the construct can be used for expressing an amphotropic/polytropic neutralizing antibody having broad-spectrum and high-efficiency neutralizing activity in vitro and in vivo and can be used for clinical research and new drug development of AIDS gene therapy drugs delivered by recombinant viral or non-viral vectors.
8.20220205989SYSTEMS INCLUDING JANUS DROPLETS
US 30.06.2022
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No 17545979 Applicant Massachusetts Institute of Technology Inventor Timothy Manning Swager

Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria).

9.WO/2022/136651METHOD FOR DETERMINING ACTIVE SARS-COV-2 INFECTIONS
WO 30.06.2022
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/EP2021/087512 Applicant CEINGE BIOTECNOLOGIE AVANZATE S.C. A R.L. Inventor CAPOLUONGO, Ettore Domenico
Method for early determination of an active SARS-CoV2 infection, based on identification of subgenomic regions of the virus, and kits specifically designed for performing it.
10.WO/2022/139769A SYSTEM FOR FAST DIAGNOSIS AND IDENTIFICATION OF DISEASES CAUSED BY VIRUSES
WO 30.06.2022
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No PCT/TR2021/051485 Applicant ATATÜRK ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ BİRİMİ Inventor PARLAK, Mehmet
The invention relates to a system providing fast diagnosis and identification of diseases caused by viruses particularly Covid-19. The system provides conduct of both virus and antibody tests by suggested sensor that enables conduct of measurement in a shorter time with better accuracy rate, comprises a sensor located in cladding with mid-part of second fibre optic cable stripped between mono-chromator and spectrometer and having nano-islets and nano-particles located therein and thus forming localised surface plasmons, a spectrometer identifying presence and quantity of RNA or antibody without change in shifting and absorption in wavelength of spectrum by conducting transmission spectrum measurements of virus RNA or antibody before and after attachment to surface, a computer improving accuracy, selectivity and detection of sensor by eliminating bias, deviation error, accuracy loss and calibration error and removing attributions from sensor response curves by applying deep learning algorithms to data obtained from sensor.