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Analysis

1.WO/2022/140232METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS
WO 30.06.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No PCT/US2021/064298 Applicant CHEN, Cheng-Yao Inventor CHEN, Cheng-Yao
A method for nucleic acid synthesis and regeneration of a reusable synthesis initiator includes incorporating a linking nucleotide to an immobilized initiator using a polymerase, synthesizing a nucleic acid right after the linking nucleotide using the polymerase, subjecting a substrate base of the linking nucleotide in the nucleic acid to base-excision by a DNA glycosylase to generate an abasic site, subjecting the abasic site to cleavage by an endonuclease to release the nucleic acid from the initiator, and converting the 3' terminus of the initiator back to its original form by a 3' phosphatase activity-possessing enzyme. A kit based on the aforesaid method and a method tor regenerating a reusable initiator are also disclosed.
2.WO/2022/140213LIMITED WELL THERMAL CYCLING DEVICE
WO 30.06.2022
Int.Class B01L 7/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
7Heating or cooling apparatus; Heat insulating devices
Appl.No PCT/US2021/064256 Applicant MATERIALS AND MACHINES CORPORATION OF AMERCIA Inventor OOMMEN, Abraham
A limited well thermal cycling device for sample preparation and real-time fluorescence detection is described. The limited well thermal cycling device includes a heating block having a sample well and at least one reaction well and an optical block including a corresponding means for measuring real time fluorescence in each reaction well. The limited well thermal cycling device includes a means for efficient heating and cooling of reaction and sample wells for real-time fluorescence detection. The structure of the heating block provides the means for efficient heating and cooling by having each of the sample well and at least one reaction wells rising above the heating block base, such that the sample well and at least one reaction well are not surrounded by the metal heating block.
3.WO/2022/138929GUIDE RNA FOR EDITING POLYADENYLATION SIGNAL SEQUENCE OF TARGET RNA
WO 30.06.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/JP2021/048231 Applicant ASTELLAS PHARMA INC. Inventor ARAI, Takatomo
[Problem] To provide an antisense guide RNA, and nucleic acid encoding same, for editing the polyadenylation signal sequence of a target RNA, with which a highly efficient control of target RNA expression can be expected. [Solution] As a result of intensive investigations into art for the highly efficient control of the expression of a target RNA, the present inventors achieved the present invention by finding a guide RNA for ADAR-mediated editing of a target RNA, comprising an antisense region that is complementary to a portion of a target RNA containing a polyadenylation signal sequence.
4.20220195476METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS
US 23.06.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 17128677 Applicant Cheng-Yao CHEN Inventor Cheng-Yao CHEN

A method for nucleic acid synthesis and regeneration of a reusable synthesis initiator includes incorporating a linking nucleotide to an immobilized initiator using a polymerase, synthesizing a nucleic acid right after the linking nucleotide using the polymerase, subjecting a substrate base of the linking nucleotide in the nucleic acid to base-excision by a DNA glycosylase to generate an abasic site, subjecting the abasic site to cleavage by an endonuclease to release the nucleic acid from the initiator, and converting the 3′ terminus of the initiator back to its original form by a 3′ phosphatase activity-possessing enzyme. A kit based on the aforesaid method and a method for regenerating a reusable initiator are also disclosed.

5.WO/2022/121301PROKARYOTE-DERIVED ARGONAUTE PROTEIN AND APPLICATION THEREOF
WO 16.06.2022
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
Appl.No PCT/CN2021/105421 Applicant HUBEI UNIVERSITY Inventor MA, Lixin
Provided are a mesophilic prokaryote kurthia massiliensis-derived Argonaute protein KmAgo and an application thereof. Also provided are a polynucleotide encoding the KmAgo and an expression vector containing the polynucleotide, a kit containing the KmAgo, a method for in vitro and intracellular cleavage of target RNA by using the KmAgo, and a method for site-specific modification of a genetic material of a cell.
6.WO/2022/125463DETECTION OF ANTI-CORONAVIRUS ANTIBODIES
WO 16.06.2022
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No PCT/US2021/062054 Applicant XIE, Qiyi Inventor XIE, Qiyi
Provided herein are methods for detecting an anti-coronavirus antibody in a biological sample using a recombinant protein comprising an amino acid sequence of an RNA dependent RNA polymerase of a coronavirus, or a variant thereof.
7.WO/2022/122689RNA MANUFACTURING
WO 16.06.2022
Int.Class A61K 31/7115
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
Appl.No PCT/EP2021/084488 Applicant BIONTECH SE Inventor ZIEGENHALS, Thomas
The present disclosure provides technologies for performing in vitro transcription that can generate product RNA preparations with reduced levels of certain contaminants (e.g., aberrant products), and particularly of double-stranded RNA (dsRNA).
8.WO/2022/119826PRODUCTS AND METHODS FOR INHIBITION OF EXPRESSION OF PERIPHERAL MYELIN PROTEIN-22
WO 09.06.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No PCT/US2021/061177 Applicant RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL Inventor HARPER, Scott Quenton
RNA interference-based methods and products for inhibiting the expression of a peripheral myelin protein-22 gene are provided. RNAs that inhibit the peripheral myelin protein-22 gene are provided as well as DMAs encoding the RNAs. Delivery vehicles such as recombinant adeno-associated viruses deliver DMAs encoding RNAs that inhibit the peripheral myelin protein-22 gene. The methods treat Charcot-Marie-Tooth Disease such as Charcot-Marie-Tooth Disease Type 1 A (CMT1A).
9.20220177937POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM
US 09.06.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 16966430 Applicant Oxford Nanopore Technologies Limited Inventor Andrew John Heron

The invention relates to new in vitro methods for synthesising a polymer, particularly a polynucleotide molecule, having a pre-defined sequence of units such as nucleotides. For synthesising a polynucleotide molecule the methods involve a process of extending a polynucleotide synthesis molecule with a transfer nucleotide. The methods additionally involve repeating the extension process multiple times to iteratively extend the polynucleotide molecule with multiple transfer nucleotides to generate a new polynucleotide molecule having a pre-defined nucleotide sequence. The invention also relates to in vitro methods of joining multiple synthetic polynucleotides following synthesis to form larger synthetic polynucleotides, as well as devices and systems for performing the extension, synthesis and assembly methods of the invention.

10.WO/2022/116378METHOD FOR CLEAVING DNA USING SOYBEAN EXTRACT BOWMAN-BIRK INHIBITOR
WO 09.06.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No PCT/CN2021/073010 Applicant JIANGNAN UNIVERSITY Inventor YANG, Zhaoqi
Disclosed is a method for cleaving DNA using a soybean extract Bowman-Birk inhibitor, which belongs to the technical field of medicines. Provided is a new use of a soybean Bowman-Birk trypsin inhibitor BBI-A. The BBI-A is used to cleave DNA, and the cleavage efficiency can reach 100% due to the optimization of conditions, such that DNA can be effectively cleaved. A new possibility is provided for preparing a DNA structural probe and potentially preparing an anti-tumor drug.