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Analysis

1.WO/2022/139522GLYCOSYLTRANSFERASE AND STEVIOL GLUCOSIDE PREPARATION METHOD USING SAME
WO 30.06.2022
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
Appl.No PCT/KR2021/019767 Applicant SAMYANG CORPORATION Inventor KIM, Jeong Min
The present invention relates to a glycosyltransferase, a composition for producing a steviol glucoside by using same, and a preparation method therefor, and, more specifically, to: a rebaudioside glycosyltransferase for transferring glucose to a steviol glucoside; a recombinant strain expressing the enzyme; and a method for producing rebaudioside, which is steviol glucoside, by using the enzyme and strain.
2.WO/2022/136222RECOMBINANT BACTERIUM AND USES THEREOF
WO 30.06.2022
Int.Class C07K 14/19
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
19Rubella virus
Appl.No PCT/EP2021/086708 Applicant CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) Inventor ASENSIO CALAVIA, Alejandro
The invention relates to a recombinant bacterium and uses thereof. In particular, it relates to the use of recombinant bacteria to translocate cargo proteins into the cytosol of target cells. Said recombinant bacteria comprises a T3 secretion system under the control of a genetic regulatory circuit and a targeting module which allow the recombinant bacteria to target specific cells, adhere to these and inject their cargo into the cytosol of the target cells.
3.WO/2022/136297NOVEL RECOMBINANT FRAGMENTS OF FIBRILLIN-1 AND METHODS OF USE THEREOF
WO 30.06.2022
Int.Class A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Appl.No PCT/EP2021/086848 Applicant INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM Inventor GENOT, Elisabeth
The present invention relates to novel recombinant fragments derived from the fibrillin-1 protein, which are particularly useful for their pro-angiogenic and vessel normalization properties, pharmaceutical compositions comprising said fragments and methods of use for the prevention and/or treatment of vascular diseases.
4.WO/2022/134107TREATMENT OF NEUROLOGICAL DISEASES
WO 30.06.2022
Int.Class A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Appl.No PCT/CN2020/139705 Applicant CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECHNOLOGY, CHINESE ACADEMY OF SCIENCES Inventor ZHOU, Haibo
Provided are methods and composition for treating certain neurodegenerative diseases, such as RGC loss-related degenerative disease and Parkinson's Disease, using in vivo conversion of glial cells to neurons by PTB and optionally nPTB knock down via CRISPR/Cas delivered by AAV vectors.
5.WO/2022/140572COMPOSITIONS AND METHODS OF USING PROGRAMMABLE NUCLEASES FOR INDUCING CELL DEATH
WO 30.06.2022
Int.Class A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Appl.No PCT/US2021/064904 Applicant MAMMOTH BIOSCIENCES, INC. Inventor HARRINGTON, Lucas, Benjamin
Disclosed herein, in certain embodiments, are methods of inducing cell cycle arrest, apoptosis, cell death, or a combination thereof, in a cell or population of cells. Also disclosed herein are methods of treating a disease or condition in an individual in need thereof comprising inducing cell cycle arrest, apoptosis, cell death, or a combination thereof in a population of cells in the individual. The cell or population of cells may comprise a nucleic acid sequence associated with a disease or condition, including an autoimmune disease, cancer, or an infectious disease. The methods described herein generally comprise contacting cells with a CRISPR-associated protein and a guide nucleic acid.
6.WO/2022/140587COMPOSITIONS AND METHODS FOR GENETICALLY MODIFYING CIITA IN A CELL
WO 30.06.2022
Int.Class C12N 5/0783
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
Appl.No PCT/US2021/064933 Applicant INTELLIA THERAPEUTICS, INC. Inventor HARRINGTON, William Frederick
Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.
7.WO/2022/140227NOVEL INSECT INHIBITORY PROTEINS
WO 30.06.2022
Int.Class A01P 7/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
7Arthropodicides
04Insecticides
Appl.No PCT/US2021/064286 Applicant MONSANTO TECHNOLGY LLC Inventor BOWEN, David J.
Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4029, TIC4029_1, and TIC4029_8. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding pesticidal proteins of the TIC4029 class. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the TIC4029 class in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC4029, TIC4029_1, and TIC4029_8 pesticidal proteins are also provided.
8.WO/2022/140257POLYNUCLEOTIDES AND METHODS FOR TRANSFERRING RESISTANCE TO ASIAN SOYBEAN RUST
WO 30.06.2022
Int.Class C12N 15/87
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Appl.No PCT/US2021/064348 Applicant PIONEER HI-BRED INTERNATIONAL, INC. Inventor JOHNSON, Ebony
Disclosed herein are compositions and methods for improving or enhancing pathogen resistance in legume plants. Compositions comprising polypeptides encoded by the CcRpp2-R1 and CcRpp2-R3 polynucleotides disclosed herein are useful in improving resistance in legumes to Asian Soybean Rust (ASR). Methods of using CcRpp2-R1 and CcRpp2-R3 genes to make transgenic ASR-resistant legume plants are also disclosed.
9.WO/2022/140797IMMUNOCYTOKINES AND USES THEREOF
WO 30.06.2022
Int.Class C12N 15/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
Appl.No PCT/US2021/073107 Applicant IMMUNOWAKE INC. Inventor WU, Ellen
The present application relates to immunocytokines comprising a cytokine or variant thereof positioned at the hinge region of a heavy chain of an antibody (e.g., full-length antibody), or positioned at a hinge region between an antigen-binding fragment (e.g., ligand, receptor, or antibody fragment) and an Fc domain subunit or portion thereof, methods of making, and uses thereof.
10.WO/2022/135457ANTI-PD-L1 ANTIBODY AND USE THEREOF
WO 30.06.2022
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/CN2021/140391 Applicant GUANGDONG FEIPENG PHARMACEUTICAL CO., LTD. Inventor LU, Lisheng
The present disclosure relates to the field of biomedicine, in particular to an anti-PD-L1 antibody and the use thereof. The anti-PD-L1 antibody or the antigen-binding fragment thereof provided in the present disclosure binds to the PD-L1 protein with a high affinity and high specificity, can effectively block the interaction between PD-L1 expressed on a cell surface and PD-1, has the biological function activity of stimulating cytokine production, and has wide application prospects.