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Analysis

1.WO/2022/132681OSCILLATING FLUIDIZED BED OLIGONUCLEOTIDE SYNTHESIZER
WO 23.06.2022
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Appl.No PCT/US2021/063185 Applicant ELI LILLY AND COMPANY Inventor BRADEN, Timothy Michael
A method and device for building an oligonucleotide on a solid phase resin within a filter reactor, wherein the method and device as used as a solid phase synthesis system. As part of the solid phase synthesis process, a protecting group will be removed from the 5’position of an oligonucleotide that is attached to the solid phase resin and then an activated amidite (phosphoamidite) solution is added. The activated amidite solution flows up and down, or fluidizes and mixes with the resin beads within the bed reactor and reacts at the 5’ position of the oligonucleotide, wherein the phosphorous linkage found within the amidite comprises a P atom that is in an oxidation state of III. Once the activated amidite solution has been reacted, the P atom is converted from an oxidation state of III to an oxidation state of V. Any of the reactions including deblocking, coupling, oxidation, sulfurization, or capping can be fluidized or mixed to get complete contacting between the reagents and the resin. Reagents drain from the reactor out the filter bottom before washing. The resin bed is flat and channel free because of the fluidization or mixing prior to the washes and can be re-fluidized during any of the washes. A spray cone or other distributor evenly spreads reagents or wash solvents onto the top of the resin bed without disrupting the flat even spread of resin in the radial direction. Washing after any given reaction can be divided into several individual segments. The cleaner portion of washes after a particular reaction in one cycle, can be collected in a holding vessel and used as the first washes after reaction in the next cycle. In-process integrated multi-pass washing can be used to enable more efficient use of the wash solvent. Excess reagent solution used for deblocking reaction is recycled and reused from one phosphoramidite cycle to the next, making the use of deblocking more efficient.
2.WO/2022/131408METHOD FOR PREPARING HIGH-PURITY ANTISENSE OLIGONUCLEOTIDE
WO 23.06.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/KR2020/018685 Applicant AUTOTELIC BIO INC. Inventor KIM, Tae Hun
The present invention relates to a method for preparing a high-purity antisense oligonucleotide. The antisense oligonucleotide intended to be synthesized by the present inventors is a nucleic acid therapeutic agent having a PS backbone as an 18-mer single DNA sequence, wherein a synthesizer AKTA OligoPilot 100 (OP100) is used in the development of a synthesis process, and the antisense oligonucleotide preparation method increases yield and purity by optimizing parameters for each step. The present invention enables the preparation of an antisense oligonucleotide having minimized impurities.
3.WO/2022/129437LONG STOKES SHIFT CHROMENOQUINOLINE DYES AND USES IN SEQUENCING APPLICATIONS
WO 23.06.2022
Int.Class C09B 57/00
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
57Other synthetic dyes of known constitution
Appl.No PCT/EP2021/086344 Applicant ILLUMINA CAMBRIDGE LIMITED Inventor CRESSINA, Elena
The present application relates to long Stokes shift chromenoquinoline dyes and their uses as fluorescent labels. For example, these dyes may be used to label nucleotides for nucleic acid sequencing applications. The chromenoquinoline dyes have Formula (I).
4.WO/2022/129930ALKYLPYRIDINIUM COUMARIN DYES AND USES IN SEQUENCING APPLICATIONS
WO 23.06.2022
Int.Class C09B 57/02
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
57Other synthetic dyes of known constitution
02Coumarine dyes
Appl.No PCT/GB2021/053343 Applicant ILLUMINA CAMBRIDGE LIMITED Inventor CRESSINA, Elena
The present application relates to alkylpyridinium substituted coumarin dyes of formula (I) and their uses as fluorescent labels. For example, these dyes may be used to label nucleotides for nucleic acid sequencing applications. wherein R 1 is or and wherein R 1 is substituted with one or more C1-C6 alkyl.
5.WO/2022/124345STABLE TARGET-EDITING GUIDE RNA TO WHICH CHEMICALLY MODIFIED NUCLEIC ACID IS INTRODUCED
WO 16.06.2022
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No PCT/JP2021/045184 Applicant FUKUOKA UNIVERSITY Inventor FUKUDA, Masatora
Provided is an oligonucleotide which can induce the editing activity of ADAR in cells and has excellent stability in a living body. The oligonucleotide includes a first oligonucleotide specifying target RNA, and a second oligonucleotide linked to the 5’ side thereof. The first oligonucleotide is composed of a target-corresponding nucleotide residue, an oligonucleotide of 10-24 residues on a 3’ side, and an oligonucleotide of 3-6 residues on a 5’ side. The second oligonucleotide lacks nucleotide residues corresponding to target RNA at the 3’ end, or has nucleotide residues that do not form a complementary pair, and has the number of residues of 2-10. The 3’ side of the target-corresponding nucleotide residue is a 2’-deoxynucleotide residue, and in the oligonucleotide on the 3’ side of the target-corresponding nucleotide residue, the third nucleotide residue from the target-corresponding nucleotide in the 3’ direction is a 2’-deoxy-2’-fluoronucleotide residue.
6.WO/2022/124663QUENCHER AND USES THEREOF
WO 16.06.2022
Int.Class C09B 11/24
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
11Diaryl- or triarylmethane dyes
04derived from triarylmethanes
10Amino derivatives of triarylmethanes
24Phthaleins containing amino groups
Appl.No PCT/KR2021/017728 Applicant SFC CO., LTD. Inventor LEE, Do Min
The present invention relates to a quencher having a quenching effect on a fluorescent material exhibiting luminescence characteristics at an excited energy level, and various uses thereof.
7.WO/2022/125564SPACING LINKER GROUP DESIGN FOR BRIGHTNESS ENHANCEMENT IN DIMERIC OR POLYMERIC DYES
WO 16.06.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/US2021/062235 Applicant SONY GROUP CORPORATION Inventor SHERIF, Hesham
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (A), or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L1a, L1b, L2, L3, L4, L5, L6, M1, M2, m, n, q, and w are as defined herein. Methods associated with preparation and use of such compounds are also provided.
8.WO/2022/125987POLY-MORPHOLINO OLIGONUCLEOTIDE GAPMERS
WO 16.06.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/US2021/062952 Applicant EISAI R&D MANAGEMENT CO., LTD. Inventor FANG, Francis, G.
Gapmers or pharmaceutically acceptable salt of the gapmers and methods of making the gapmers are provided. The gapmers include a gap region that contains deoxyribonucleosides linked to each other by phosphorothioate bonds, a 5' wing region positioned at the 5' end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds, and a 3' wing region positioned at the 3' end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds. Antisense oligonucleotides are also provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription.
9.WO/2022/122613NOVEL SYNTHESIS OF PHOSPHORODITHIOATE OLIGONUCLEOTIDES
WO 16.06.2022
Int.Class C07H 1/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
02Phosphorylation
Appl.No PCT/EP2021/084316 Applicant F. HOFFMANN-LA ROCHE AG Inventor BOLLMARK, Martin
The invention provides the use of a compound of formula (I), as defined, for the preparation of an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage. Various synthesis methods using compounds of formula (I) are provided.
10.WO/2022/124789QUENCHER AND USE THEREOF
WO 16.06.2022
Int.Class C09B 11/24
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
11Diaryl- or triarylmethane dyes
04derived from triarylmethanes
10Amino derivatives of triarylmethanes
24Phthaleins containing amino groups
Appl.No PCT/KR2021/018524 Applicant SFC CO., LTD. Inventor LEE, Do Min
The present invention relates to a quencher exhibiting a quenching effect on a fluorescent material exhibiting luminescence properties at an excited energy level, and various uses thereof.