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Analysis

1.WO/2022/140257POLYNUCLEOTIDES AND METHODS FOR TRANSFERRING RESISTANCE TO ASIAN SOYBEAN RUST
WO 30.06.2022
Int.Class C12N 15/87
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Appl.No PCT/US2021/064348 Applicant PIONEER HI-BRED INTERNATIONAL, INC. Inventor JOHNSON, Ebony
Disclosed herein are compositions and methods for improving or enhancing pathogen resistance in legume plants. Compositions comprising polypeptides encoded by the CcRpp2-R1 and CcRpp2-R3 polynucleotides disclosed herein are useful in improving resistance in legumes to Asian Soybean Rust (ASR). Methods of using CcRpp2-R1 and CcRpp2-R3 genes to make transgenic ASR-resistant legume plants are also disclosed.
2.20220202964HEPARANASE COMPOUNDS AND METHODS OF USE
US 30.06.2022
Int.Class A61K 51/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
Appl.No 17605144 Applicant University of Florida Research Foundation, Incorporated Inventor Lina Cui

The invention relates to compounds that interact with heparanase, uses in heparanase screening, uses in in vitro and in vivo imaging (e g , positron emission tomography (PET) and magnetic resonance imaging (MRI)), methods of synthesis, methods of modulating heparanase activity, and methods of treating disease and disorders associated with heparanase. The compounds of the invention are also useful in treating one or more diseases or disorders associated with the function of heparanase.

3.WO/2022/140365GALNAC COMPOSITIONS FOR IMPROVING SIRNA BIOAVAILABILITY
WO 30.06.2022
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Appl.No PCT/US2021/064581 Applicant EMPIRICO INC. Inventor WAKEFIELD, Darren H.
Provided herein, are compositions comprising GalNAc moieties that may be conjugated to an oligonucleotide. The oligonucleotide may be a small interfering RNA or an antisense oligonucleotide. Also provided herein are methods of treatment that include administering the composition to a subject.
4.202202045456-AZA-NUCLEOSIDE PRODRUGS AS ANTIVIRAL AGENTS FOR TREATING VIRUS INFECTIONS
US 30.06.2022
Int.Class C07H 19/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
12Triazine radicals
Appl.No 17554979 Applicant Southern Research Institute Inventor Omar Moukha-Chafiq

The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

5.WO/2022/135173ESCHERICHIA COLI STRAIN AND USE THEREOF IN PRODUCTION OF POLYSIALIC ACID
WO 30.06.2022
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
Appl.No PCT/CN2021/136947 Applicant BLOOMAGE BIOTECHNOLOGY CORPORATION LIMITED Inventor ZHANG, Tianmeng
Provided is an Escherichia coli strain, H03A2190830. The deposit number thereof is CCTCC NO: M2019900. Further provided are a method for producing a polysialic acid by means of using the Escherichia coli, and a method for producing a sialic acid by means of using the polysialic acid prepared from the present method. When using the strain to produce the polysialic acid, not only can the production time be shortened and the production cost be reduced, but also a polysialic acid with a relatively high yield can be obtained, and therefore the strain has good industrial application prospects.
6.WO/2022/135319METHOD FOR AUTOMATIC PREPARATION OF FONDAPARINUX SODIUM PENTOSACCHARIDE INTERMEDIATE
WO 30.06.2022
Int.Class C07H 15/203
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
Appl.No PCT/CN2021/139518 Applicant PEKING UNIVERSITY Inventor YE, Xinshan
The present invention relates to a method for the automatic preparation of a fondaparinux sodium pentasaccharide intermediate. The method is based on an automatic preparation device. According to the method, automatic preparation of three components (D+EF+GH) is realized by means of automatic sample injection, and automatic sampling and monitoring, so as to obtain the fully-protected fondaparinux sodium pentasaccharide intermediate (formula I), thereby realizing the automatic synthesis of the fondaparinux sodium pentasaccharide intermediate, saving on the investment of labor, improving the efficiency and productivity, and having a relatively high safety and reproducibility. The method can be directly monitored online, which is convenient for optimizing and monitoring the real-time status of the reaction. At the same time, the automatic temperature control can better meet the requirements of the reaction for heating and cooling. A pre-activation one-kettle mode is used, such that the number of times of separation are reduced and the operation is convenient. A common ester protecting group is selected, a relatively high stereoselectivity and yield are achieved, and a universal deprotection method can be used. The method has an important significance in reducing the production cost of fondaparinux sodium and achieving large-scale production thereof. The definition of each substituent in formula I is the same as the definition in the description.
7.WO/2022/140404ZWITTERIONIC LIPID NANOPARTICLE COMPOSITIONS, AND METHODS OF USE
WO 30.06.2022
Int.Class A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
Appl.No PCT/US2021/064639 Applicant CORNELL UNIVERSITY Inventor LUOZHONG, Sijin
A lipid nanoparticle composition comprising: (i) at least one zwitterionic polymer-containing lipid in which a lipid moiety is covalently attached to a zwitterionic polymer; (ii) at least one non-cationic lipid selected from charged and uncharged lipids, but not attached to a polymer; (iii) at least one cationic or ionizable lipid; and (iv) at least one therapeutic substance, and optionally (v) cholesterol or derivative thereof. Also described herein are methods of delivering a therapeutic substance to a subject, the method comprising administering to the subject a lipid nanoparticle composition described above.
8.WO/2022/140581METHODS AND COMPOSITIONS FOR MEASURING AND INHIBITING EXONUCLEASE ACTIVITY
WO 30.06.2022
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Appl.No PCT/US2021/064922 Applicant NEW YORK UNIVERSITY Inventor PAGANO, Michele
The present disclosure relates to novel methods and compositions for a measuring exonuclease enzyme activity. In particular, the methods entail contacting a sample with a fluorescently-labeled substrate to create a test mixture, incubating the test mixture for a time sufficient for cleavage of the substrate, and measuring the fluorescence signal from the test reaction mixture. In certain aspects, the methods disclosed herein are useful for identifying and/or assessing a modulator of an exonuclease that may be used either alone or in combination with other compounds. The present disclosure also relates to fluorescently-labeled double- stranded nucleic acid compositions useful in the practice of such methods and, still further, to kits for performing the methods of the disclosure. The present disclosure further relates to compounds and methods useful for treating a viral infection.
9.WO/2022/134385PURIFICATION METHOD FOR 4"-(S)-METHYLAMINO ABAMECTIN B2A BENZOATE
WO 30.06.2022
Int.Class C07H 1/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
06Separation; Purification
Appl.No PCT/CN2021/086469 Applicant HEBEI VEYONG BIO-CHEMICAL CO., LTD Inventor WANG, Bo
The present invention relates to the technical field of agricultural chemicals and preparation. Specifically, disclosed is a purification method for 4"-(s)-methylamino abamectin B2a benzoate. The purification method comprises the following steps: adding a crude product of methylamino abamectin B2a/2b benzoate to methyl tert-butyl ether, heating and dissolving, dropwise adding a mixed solution of tert-butanol and n-butyl ether, cooling and filtering after the dropwise adding, and cooling and crystallizing an obtained filtrate to obtain a product of 4"-(s)-methylamino abamectin B2a benzoate. According to the purification method provided by the present invention, by selecting the mixed solution of methyl tert-butyl ether, tert-butanol and n-butyl ether as a crystallization solvent, and in coordination with twice cooling and crystallization, the product of 4"-(s)-methylamino abamectin B2a benzoate having S-configured methylamino at bit 4" and having a content of 98% or more is obtained, thereby facilitating improvement of the insecticidal activity of related preparations, and achieving a wide application prospect.
10.WO/2022/138748LABELING METHOD, OXIDANT FOR LABELING, RUTHENIUM COMPLEX, CATALYST, LABELING COMPOUND, AND COMPOUND
WO 30.06.2022
Int.Class C07B 59/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds
Appl.No PCT/JP2021/047658 Applicant KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION Inventor UCHIDA Tatsuya
The present invention provides a labeling method that comprises a step for labeling a substrate, which has a carbon-hydrogen bond, with an oxygen isotope with use of a catalyst and an oxidant that is produced from a hypervalent iodine compound having an ester structure and labeled water which is labeled with at least one oxygen isotope that is selected from the group consisting of 17O and 18O. The present invention also provides an oxidant for labeling, said oxidant being produced from a hypervalent iodine compound having an ester structure and labeled water which is labeled with at least one oxygen isotope that is selected from the group consisting of 17O and 18O. This oxidant for labeling labels a substrate, which has a carbon-hydrogen bond, with an oxygen isotope in the coexistence of a catalyst.