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IC:G01N33/569

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Analysis

1.WO/2022/167498MASS-SPECTROMETRIC METHOD FOR PATHOGEN DETECTION
WO 11.08.2022
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No PCT/EP2022/052509 Applicant UNIVERSITEIT LEIDEN Inventor HANKEMEIER, Thomas
The invention relates to a mass-spectrometry method for detecting pathogens. The method is highly sensitive and is therefore particularly useful for detecting peptides that are present in only low concentrations, such as pathogen peptides in a swab sample obtained from a subject.
2.WO/2022/169898LIPOTEICHOIC ACID (LTA) APTAMERS AND ASSOCIATED METHODS
WO 11.08.2022
Int.Class C12N 15/115
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
Appl.No PCT/US2022/014975 Applicant FRESENIUS MEDICAL CARE HOLDINGS, INC. Inventor JIANG, Tao
Described are a number of aptamers that are specific to bind with lipoteichoic acid (LTA), and associated methods
3.20220252588NEUTRALIZING ANTIBODY TESTING AND TREATMENT
US 11.08.2022
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No 17726431 Applicant SAPPHIRE BIOTECH, INC. Inventor Sergei SVAROVSKY

A method for detection and measurement of neutralizing antibody levels to SARS-CoV-2 in a test-specimen, said method comprising obtaining a test-specimen from a subject, transferring the test-specimen to a sample well of a test-cassette, wherein the cassette further comprises a sample pad, a conjugate pad, a nitrocellulose membrane and an absorbent pad, wherein the sample pad comprises ACE2 or a functional fragment thereof, wherein the conjugate pad comprises a plurality of viral-ACE2-binding protein coupled to a plurality of labels, adding a buffer and reading the results from the test-cassette.

4.WO/2022/165609RECOMBINANT PLANT-DERIVED ANTIBODIES AND FC VARIANTS AND RELATED METHODS
WO 11.08.2022
Int.Class C07K 16/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
Appl.No PCT/CA2022/050177 Applicant HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD Inventor MENASSA, Rima
The present application describes polypeptides comprising a variant Fc chain that exhibits enhanced accumulation in an organism and methods of producing the same. A method of enhancing accumulation of a protein is also described. The present application also describes polypeptides which specifically bind to intimin on an Escherichia coli cell, including antibodies and antigen-binding fragments thereof, and methods of producing the same. Also described is a method of preventing or reducing colonization of E. coli in the gastrointestinal tract of a mammal. A method of detecting the presence of E. coli in a sample is also described.
5.WO/2022/166494CONSTRUCTION METHOD FOR MASS SPECTRUM MODEL FOR DIAGNOSING COVID-19
WO 11.08.2022
Int.Class G01N 27/62
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
Appl.No PCT/CN2021/143445 Applicant BEIJING YIXINBOCHUANG BIOTECHNOLOGY CO. , LTD. Inventor LIAO, Pu
A characteristic polypeptide composition for detecting COVID-19, comprising 29 characteristic polypeptides having specific mass-to-charge ratios. By analyzing the expression of the characteristic polypeptides, whether a sample is a COVID-19 patient can be determined. Also provided is use of the characteristic polypeptide composition in preparation of a mass spectrum model and a product for diagnosing COVID-19, etc. For the first time, an approach of finding a plurality of characteristic protein combinations having differences from COVID-19 patients/normal people, pulmonary tuberculosis patients, and a control having COVID-19 type symptoms is proposed, and a conventional search approach for finding characteristic polypeptides merely from normal people and COVID-19 patients is broken through, infection of false positive results having symptoms similar to those of COVID-19 is effectively avoided, operations are simple, detection cost is low, accuracy is high, and the present invention is expected to be used for large-scale screening of COVID-19.
6.WO/2022/167784MONITORING COVID-19 PROGRESSION AND TREATMENT
WO 11.08.2022
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Appl.No PCT/GB2022/050262 Applicant SEROXO LIMITED Inventor SARPHIE, David
The present invention provides a rapid method using whole blood samples for determining the severity of COVID-19 disease arising from SARS-CoV-2 infection and monitoring progression and treatment of the disease relying on determination of the functionality of leukocytes (predominately neutrophils) to exhibit challenge-induced superoxide anion production with quantification by chemiluminescent measurement.
7.20220252604METHODS FOR CULTURING STEM AND PROGENITOR CELLS
US 11.08.2022
Int.Class G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Appl.No 17353705 Applicant MINERVA BIOTECHNOLOGIES CORPORATION Inventor Cynthia Bamdad

The present application describes a method of culturing, expanding or growing stem or stem-like cells or induced pluripotent stem cells on a surface, including attaching the cells to the surface through a ligand that binds to the surface and the cells.

8.WO/2022/165693METHOD AND REAGENT FOR DETECTING MYCOBACTERIUM TUBERCULOSIS
WO 11.08.2022
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/CN2021/075197 Applicant BEIJING CHEST HOSPITAL, CAPITAL MEDICAL UNIVERSITY Inventor PANG, Yu
Disclosed is a diagnostic marker for diagnosing whether a patient is infected with Mycobacterium tuberculosis. The marker comprises one or a combination of two or more of factors selected from a cytokine, C-reactive protein, and white blood cell count. Preferably, the cytokine is one or a combination of two or more of factors selected from interleukin (IL), interferon (IFN), and tumor-necrosis factor (TNF).
9.WO/2022/169279COMPOSITION FOR PREVENTION OR TREATMENT OF KIDNEY DISEASE
WO 11.08.2022
Int.Class A61K 35/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
Appl.No PCT/KR2022/001727 Applicant INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY Inventor NAM, Ki Taek
Kidney organ-derived stem cells or organoids according to the present disclosure: are easy to apply to a therapeutic procedure; can be supplied in a large amount due to the high self-proliferation rate thereof; have a high potential to differentiate into renal cells; are highly unlikely to form a tumor; and have an excellent ability to regenerate damaged tissues when directly injected into a lesion. Therefore, the stem cells can be very appropriately used for adult stem cell-based regenerative therapy, inter alia. In addition, a composition according to the present invention can specifically select only renal stem cells among renal cells. Furthermore, renal stem cells expressing Lrig1 protein or a gene coding therefor are superb in terms of renewal ability and pluripotency and possess the potential of differentiating to nephrons and as such, can find very effective applications in preventing or treating kidney diseases.
10.WO/2022/169984PROTEIN M ANALOGS AND FUSION PROTEINS AND THEIR USE FOR INHIBITING ANTIBODY FUNCTION
WO 11.08.2022
Int.Class C07K 14/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
30from Mycoplasmatales, e.g. Pleuropneumonia-like organisms (PPLO)
Appl.No PCT/US2022/015127 Applicant THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Inventor ASKEW, Charles
This invention relates to methods and compositions for binding antibodies. The methods may be used to isolate antibodies, treat disorders related to excess antibodies, acutely block antibodies to stop an autoimmune or inflammatory response, and inhibit neutralizing antibodies. In embodiments, the invention relates to methods of inhibiting neutralizing antibodies against a heterologous agent when the heterologous agent is administered to a subject, comprising administering to the subject an effective amount of mycoplasma protein M or a functional fragment or derivative thereof, thereby inhibiting neutralization of the heterologous agent. The invention further relates to modified mycoplasma protein M or functional fragments thereof having increased thermostability relative to wild-type protein M and their use in the methods of the invention.