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Analysis

1.20220252574IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USING
US 11.08.2022
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Appl.No 17629309 Applicant University of Louisville Research Foundation, Inc. Inventor Kevin Joseph Sokoloski

Immunomodulatory compositions that include at least one alphavirus capsid protein and methods of using such immunomodulatory compositions. In one aspect, methods of immunomodulating IL-1/TLR signaling in a cell are provided. Such methods typically include contacting the cell with an alphavirus capsid protein or a portion thereof, thereby immunomodulating IL-1/TLR signaling in the cell.

2.WO/2022/167498MASS-SPECTROMETRIC METHOD FOR PATHOGEN DETECTION
WO 11.08.2022
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No PCT/EP2022/052509 Applicant UNIVERSITEIT LEIDEN Inventor HANKEMEIER, Thomas
The invention relates to a mass-spectrometry method for detecting pathogens. The method is highly sensitive and is therefore particularly useful for detecting peptides that are present in only low concentrations, such as pathogen peptides in a swab sample obtained from a subject.
3.WO/2022/168908PRODUCTION METHOD FOR INTESTINAL TRACT CELLS DERIVED FROM PLURIPOTENT STEM CELLS AND HAVING CRYPT-VILLUS-LIKE STRUCTURES, AND USE THEREOF
WO 11.08.2022
Int.Class C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Appl.No PCT/JP2022/004220 Applicant PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY Inventor MATSUNAGA Tamihide
The purpose of the present invention is to provide a production method for intestinal tract cells derived from pluripotent stem cells and having crypt-villus-like structures, said method making it possible to achieve crypt-villus-like structures like those in a living intestinal tract as well as further achieve efficient differentiation into intestinal tract epithelial cells and functional improvement of said cells. According to the present invention, provided is a method for producing intestinal tract cells from pluripotent stem cells, said method including (1) a step for differentiating pluripotent stem cells into endoderm-like cells, (2) a step for differentiating the endoderm-like cells into intestinal tract stem cell-like cells, (3) a step for culturing the intestinal tract stem cell-like cells in the presence of certain factors, (4) a step for culturing the aforementioned cells and forming spheroids, (5) a step for differentiating the spheroids and forming intestinal tract organoids, and (6) a step for gas-phase/liquid-phase culturing of cells constituting the intestinal tract organoids in the presence of certain factors.
4.WO/2022/168953CARTILAGE DEGENERATION ANALYSIS DEVICE, DEVICE FOR DIAGNOSING OR AIDING DIAGNOSIS WHICH CONTAINS SAME, METHOD FOR DETERMINING DEGREE OF DEGENERATION OF CARTILAGE, AND METHOD FOR EVALUATING DRUG EFFICACY OF TEST SUBSTANCE
WO 11.08.2022
Int.Class A61B 10/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
10Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
Appl.No PCT/JP2022/004512 Applicant NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY Inventor ITAKA Keiji
Provided is an analysis device for detecting an early stage of cartilage degeneration caused by osteoarthritis or the like. One aspect of the present invention pertains to a cartilage degeneration analysis device which has a processing unit which includes an indicator calculation unit configured so as to calculate a value which expresses at least one indicator from a group of indicators comprising (a) collagen secondary structure, (b) collagen hydration level, (c) glycosaminoglycan composition and total amount, and (d) protein glycosylation level and glycosaminoglycan total amount, on the basis of a Raman spectrum obtained by Raman spectroscopy in which the cartilage of an imaging subject is irradiated with excitation light.
5.WO/2022/169898LIPOTEICHOIC ACID (LTA) APTAMERS AND ASSOCIATED METHODS
WO 11.08.2022
Int.Class C12N 15/115
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
Appl.No PCT/US2022/014975 Applicant FRESENIUS MEDICAL CARE HOLDINGS, INC. Inventor JIANG, Tao
Described are a number of aptamers that are specific to bind with lipoteichoic acid (LTA), and associated methods
6.202022101928Auf maschinellem Lernen basierendes System zur Erkennung von Brustkrebs mit einem Nahfeld-Mikrowellen-Antennensensor
DE 11.08.2022
Int.Class G16H 50/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
Appl.No 202022101928 Applicant Chowdhury Manas Ranjan Inventor

Ein auf maschinellem Lernen basierendes System (10) zur Erkennung von Brustkrebs unter Verwendung eines Nahfeld-Mikrowellen- Antennensensors, wobei das System umfasst: einen Mikrowellenantennensensor (1), der zum Senden und Empfangen von Mikrowellensignalen verwendet wird, wobei der Mikrowellenantennensensor (1) so positioniert ist, dass er Mikrowellenenergie in die Brust sendet und die gesendete Mikrowellenenergie empfängt, nachdem das Signal in die Brust gelangt ist; eine Mikrowellenantennensensor-Positionseinstellvorrichtung (2), wobei die Mikrowellenantennensensor-Positionseinstellvorrichtung (2) verwendet wird, um den Mikrowellenantennensensor (1) von einer Position zu einer anderen Position zu bewegen, um den Tumorort auf der Brust zu erfassen; eine Kommunikationseinheit (3), die zur Übermittlung der Informationen vom Mikrowellenantennensensor (1) verwendet wird; und eine zentrale Steuereinheit (4), die so konfiguriert ist, dass sie einen maschinellen Lernalgorithmus verarbeitet, der das Vorhandensein von Werten unterhalb eines Schwellenwerts in dem empfangenen Mikrowellensignal bestimmt, die mit dem Vorhandensein eines Brustkrebses im Brustgewebe in Verbindung stehen. embedded image

7.20220252588NEUTRALIZING ANTIBODY TESTING AND TREATMENT
US 11.08.2022
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No 17726431 Applicant SAPPHIRE BIOTECH, INC. Inventor Sergei SVAROVSKY

A method for detection and measurement of neutralizing antibody levels to SARS-CoV-2 in a test-specimen, said method comprising obtaining a test-specimen from a subject, transferring the test-specimen to a sample well of a test-cassette, wherein the cassette further comprises a sample pad, a conjugate pad, a nitrocellulose membrane and an absorbent pad, wherein the sample pad comprises ACE2 or a functional fragment thereof, wherein the conjugate pad comprises a plurality of viral-ACE2-binding protein coupled to a plurality of labels, adding a buffer and reading the results from the test-cassette.

8.20220251649Nucleic Acid Taggants
US 11.08.2022
Int.Class C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
Appl.No 17731006 Applicant eBay Inc. Inventor Sergio Pinzon Gonzales, JR.

The present disclosure relates to compositions and methods for marking/tagging objects for identification. In particular, tagging objects with a nucleic acid taggant (genetic tag based merchandise authentication).

9.WO/2022/165609RECOMBINANT PLANT-DERIVED ANTIBODIES AND FC VARIANTS AND RELATED METHODS
WO 11.08.2022
Int.Class C07K 16/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
Appl.No PCT/CA2022/050177 Applicant HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD Inventor MENASSA, Rima
The present application describes polypeptides comprising a variant Fc chain that exhibits enhanced accumulation in an organism and methods of producing the same. A method of enhancing accumulation of a protein is also described. The present application also describes polypeptides which specifically bind to intimin on an Escherichia coli cell, including antibodies and antigen-binding fragments thereof, and methods of producing the same. Also described is a method of preventing or reducing colonization of E. coli in the gastrointestinal tract of a mammal. A method of detecting the presence of E. coli in a sample is also described.
10.WO/2022/166494CONSTRUCTION METHOD FOR MASS SPECTRUM MODEL FOR DIAGNOSING COVID-19
WO 11.08.2022
Int.Class G01N 27/62
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
Appl.No PCT/CN2021/143445 Applicant BEIJING YIXINBOCHUANG BIOTECHNOLOGY CO. , LTD. Inventor LIAO, Pu
A characteristic polypeptide composition for detecting COVID-19, comprising 29 characteristic polypeptides having specific mass-to-charge ratios. By analyzing the expression of the characteristic polypeptides, whether a sample is a COVID-19 patient can be determined. Also provided is use of the characteristic polypeptide composition in preparation of a mass spectrum model and a product for diagnosing COVID-19, etc. For the first time, an approach of finding a plurality of characteristic protein combinations having differences from COVID-19 patients/normal people, pulmonary tuberculosis patients, and a control having COVID-19 type symptoms is proposed, and a conventional search approach for finding characteristic polypeptides merely from normal people and COVID-19 patients is broken through, infection of false positive results having symptoms similar to those of COVID-19 is effectively avoided, operations are simple, detection cost is low, accuracy is high, and the present invention is expected to be used for large-scale screening of COVID-19.