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Analysis

1.20220251644TUBE LENS DESIGN FOR IMPROVED DEPTH-OF-FIELD
US 11.08.2022
Int.Class C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
Appl.No 17723280 Applicant Element Biosciences, Inc. Inventor Steve Xiangling CHEN

Imaging systems and methods comprising imaging a first interior surface and a second interior surface of a flow cell are described. In some embodiments, the imaging systems may comprise: a) an objective lens; b) at least one image sensor; and c) at least one tube lens disposed in an optical path between the objective lens and the at least one image sensor; wherein the at least one tube lens is configured to correct imaging performance such that images of the first interior surface of the flow cell and the second interior surface of the flow cell have substantially the same optical resolution.

2.WO/2022/167813METHOD OF TRANSPOSON INSERTION SITE SEQUENCING CAPABLE OF UNIQUELY IDENTIFYING INSERTIONS SITES WITHIN REPEATED GENETIC ELEMENTS
WO 11.08.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/GB2022/050303 Applicant QUADRAM INSTITUTE BIOSCIENCE Inventor WEBBER, Mark
A method of transposon insertion sequencing (TIS) capable of resolving insertion sites in or around repeat elements, said method including the steps of; preparing a pool or library of mutant cells by introduction or insertion of one or more transposon sequences, extraction of DNA from said cells, DNA fragmentation, DNA amplification, and characterised in that the amplified DNA is sequenced by a long-read sequencing method.
3.WO/2022/168908PRODUCTION METHOD FOR INTESTINAL TRACT CELLS DERIVED FROM PLURIPOTENT STEM CELLS AND HAVING CRYPT-VILLUS-LIKE STRUCTURES, AND USE THEREOF
WO 11.08.2022
Int.Class C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Appl.No PCT/JP2022/004220 Applicant PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY Inventor MATSUNAGA Tamihide
The purpose of the present invention is to provide a production method for intestinal tract cells derived from pluripotent stem cells and having crypt-villus-like structures, said method making it possible to achieve crypt-villus-like structures like those in a living intestinal tract as well as further achieve efficient differentiation into intestinal tract epithelial cells and functional improvement of said cells. According to the present invention, provided is a method for producing intestinal tract cells from pluripotent stem cells, said method including (1) a step for differentiating pluripotent stem cells into endoderm-like cells, (2) a step for differentiating the endoderm-like cells into intestinal tract stem cell-like cells, (3) a step for culturing the intestinal tract stem cell-like cells in the presence of certain factors, (4) a step for culturing the aforementioned cells and forming spheroids, (5) a step for differentiating the spheroids and forming intestinal tract organoids, and (6) a step for gas-phase/liquid-phase culturing of cells constituting the intestinal tract organoids in the presence of certain factors.
4.WO/2022/170228METHODS FOR MANUFACTURING A SYNTHETIC TEMPLATE
WO 11.08.2022
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/US2022/015573 Applicant NUTCRACKER THERAPEUTICS, INC. Inventor DEUTSCH, Samuel
Provided herein is a method of making, comprising transporting reagents to a reactor in a microfluidic path device, wherein the reagents include a synthetic gene of interest, a polymerase, a buffer, a first primer having a first region specific to the synthetic gene of interest, and a second primer, wherein the second primer comprises a poly-T sequence of ≥150 base pairs (bp) or a poly-A sequence of ≥150 bp and a second region specific to the synthetic gene of interest; controlling a temperature of the first reactor to perform a polymerase chain reaction within the microfluidic path device to amplify the synthetic gene of interest using the first primer and the second primer to form a synthetic product including the poly-A sequence of ≥150 bp; and transporting the synthetic product out of the first reactor, wherein the synthetic product comprises a synthetic DNA template for in vitro transcription.
5.20220251648HETEROCHIRAL TRANSLATORS AND MOLECULAR CIRCUITS
US 11.08.2022
Int.Class C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
Appl.No 17669007 Applicant UNM RAINFOREST INNOVATIONS Inventor Tracy L. Mallette

A heterochiral strand displacement molecular circuit generally includes an input oligonucleotide, a first translator, a second translator, and an output oligonucleotide. The first translator generally includes a domain that binds to the input binding oligonucleotide, at least a portion of which is complementary to, and has the same chirality as, the input oligonucleotide. The first translator also includes a translation domain having chirality opposite the chirality of the input oligonucleotide (and the binding domain). The second translator generally includes a nucleotide sequence, at least a portion of which is complementary to, and has the same chirality as, the translation domain of the first translator. The output oligonucleotide includes a nucleotide sequence, at least a portion of which is complementary to, and has the same chirality as, the second translator.

6.20220251649Nucleic Acid Taggants
US 11.08.2022
Int.Class C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
Appl.No 17731006 Applicant eBay Inc. Inventor Sergio Pinzon Gonzales, JR.

The present disclosure relates to compositions and methods for marking/tagging objects for identification. In particular, tagging objects with a nucleic acid taggant (genetic tag based merchandise authentication).

7.WO/2022/166734SDC2 METHYLATION DETECTION KIT AND APPLICATION THEREOF
WO 11.08.2022
Int.Class C12Q 1/6858
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6858Allele-specific amplification
Appl.No PCT/CN2022/074196 Applicant SHANGHAI HEALZONE BIOTECHNOLOGY CO., LTD Inventor XU, Hong
The present application provides an SDC2 methylation detection kit and an application thereof. The kit comprises a methylation-dependent restriction enzyme, a capture oligonucleotide, and a universal primer; the capture oligonucleotide comprises, in order from terminal 5' to terminal 3': a first universal sequence, a folding sequence, and a binding capture sequence; the folding sequence is at least partially identical to a 5' end sequence of an SDC2 methylation site subjected to the digestion of the methylation-dependent restriction enzyme; the binding capture sequence specifically binds to a fragment region where a detected SDC2 methylation site is located. According to the present application, on the basis of the methylation-dependent restriction enzyme and a universal primer fluorescence quantitative PCR technology, no bisulfite conversion is required, sensitive and specific SDC2 methylation detection is achieved, and a detection limit is as low as 10 copies/reaction.
8.WO/2022/170124SYSTEMS AND METHODS FOR ANALYSIS OF SAMPLES
WO 11.08.2022
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2022/015355 Applicant IDBYDNA INC. Inventor BROADBENT, Kate
Systems and methods for determining an amount of a predefined category are provided. A sample is obtained, including nucleic acids from the predefined category and nucleic acids from a source other than the predefined category. A known quantity of an internal control material comprising nucleic acids is added to the sample. The sample, including the internal control material, is sequenced. A sequencing dataset including sequence reads from the predefined category and sequence reads from the internal control material is obtained. A first read count, normalized using a first target nucleotide length, of sequence reads from the predefined category, and a second read count, normalized using a second target nucleotide length, of sequence reads from the internal control material are determined. The amount of the predefined category in the sample is calculated based on the first read count, the second read count, and the known quantity of the internal control material.
9.WO/2022/168774ESTIMATION DEVICE, LEARNING DEVICE, OPTIMIZATION DEVICE, ESTIMATION METHOD, LEARNING METHOD, AND OPTIMIZATION METHOD
WO 11.08.2022
Int.Class G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Appl.No PCT/JP2022/003522 Applicant SHIMADZU CORPORATION Inventor SUZUKI, Takashi
This estimation device (200) generates quality prediction data (540) representing the quality of a drug substance for a biopharmaceutical manufactured through culturing cells by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance within a culturing vessel at at least one timing after a specified interval has passed since seeding the cells in a culture medium. The prediction model (420) is generated by executing learning processing using data for learning (530) including measurement data that includes measurement results obtained by measuring the substance within the culturing vessel at a plurality of timings after seeding the cells in the culture medium, and quality data obtained by analyzing the drug substance for a biopharmaceutical manufactured from the cells.
10.WO/2022/169899SWAB COLLECTION MEDIA FOR CAPTURE OF AIRBORNE PARTICLE SAMPLES
WO 11.08.2022
Int.Class G01N 1/22
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
02Devices for withdrawing samples
22in the gaseous state
Appl.No PCT/US2022/014976 Applicant AEROSOL DEVICES INC Inventor HESKETT, Dominick Dalton Reyes
The present invention features a device and method for directly collecting airborne particles onto a swab collection substrate. Prior to collection, water vapor may be condensed onto the particles to increase their average diameter. The particles are expelled from one or more acceleration nozzles for gentle impaction onto the swab collection substrate and may be further analyzed through chemical or biological assays.