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1.WO/2022/165789CIS REPLICON RNA CONSTRUCT FOR EFFICIENTLY EXPRESSING TARGET PROTEIN
WO 11.08.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/CN2021/075746 Applicant ZHENGZHOU UNIVERSITY Inventor ZHANG, Shoutao
Disclosed is a cis replicon RNA construct for efficiently expressing a target protein, which comprises, in the 5'-3' direction, a 5'UTR sequence containing a 5'-cap structure; one or more nucleotide sequences encoding a replicase; a 5'-terminal recognition sequence for guiding the replication of an RNA replicon and a subgenome promoter SGP; multiple cloning sites; a target gene or heterologous nucleotide sequence, which is controlled by the subgenome promoter; a 3'-terminal recognition sequence for guiding the replication of the RNA replicon; and 3'UTR and 3'polyA for ensuring the stability of RNA and the effective replication of the target gene. The RNA replicon is constructed by means of modifying the alphavirus genome, only efficient replication and expression of the target gene are driven, and the aims of reducing the expression of a non-target protein to the maximum extent and increasing the expression of a target protein are achieved, thereby providing a basis for the effective and safe production of the target protein in an organism and realizing the potential medical application value.
2.WO/2022/166959CIS-REPLICON CONSTRUCT
WO 11.08.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/CN2022/075384 Applicant ZHENGZHOU UNIVERSITY Inventor ZHANG, Shoutao
Provided is a new-type cis-replicon construct for efficiently expressing a target protein, which comprises an RNA polymerase coding unit and a target protein coding unit. The replicon construct can drive the replication of the target protein coding unit and reduce or avoid the replication and expression of the RNA polymerase, thereby effectively improving the expression of the target protein and reducing the expression of the non-target protein.
3.4039810VECTORS FOR USE IN AN INDUCIBLE COEXPRESSION SYSTEM
EP 10.08.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 21214179 Applicant ABSCI LLC Inventor MCCLAIN SEAN
The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.
4.WO/2022/161495RECOMBINANT SARS-COV-2 VACCINE
WO 04.08.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/CN2022/075134 Applicant GENESAIL BIOTECH (SHANGHAI) CO., LTD. Inventor LIANG, Min
Provided are SARS-CoV-2 vaccines useful for treating or protecting a subject from infection by SARS-CoV-2. The SARS-CoV-2 vaccines contain nucleic acids encoding at least one type of S protein variant, and other factors useful for treating or protecting a subject from infection by SARS-CoV-2, or expression vectors or viruses containing such nucleic acids, or host cells containing such nucleic acids or expression vectors.
5.WO/2022/163507COMPOSITION FOR NUCLEIC ACID AMPLIFICATION
WO 04.08.2022
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
Appl.No PCT/JP2022/002103 Applicant NOF CORPORATION Inventor KONDO, Seina
The present invention provides a composition for nucleic acid amplification which contains a polymer which contains a constituent unit derived from 2-(meth)acryloyloxyethyl phosphorylcholine.
6.WO/2022/163647ORAL CORONAVIRUS INFECTION VACCINE
WO 04.08.2022
Int.Class C12N 1/21
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
21modified by introduction of foreign genetic material
Appl.No PCT/JP2022/002677 Applicant NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY Inventor SHIRAKAWA, Toshiro
Provided is a vaccine that can be administered orally against coronavirus infection. A vaccine that can be administered orally against coronavirus infection can be provided by transformed bifidobacteria designed so as to present some or all of the proteins that constitute the coronavirus on the bifidobacterium surface layer. Transformed bifidobacteria designed so as to present some or all of the proteins that constitute the coronavirus on the bifidobacterium surface layer induce humoral immunity and cellular immunity by oral administration and can suppress any increase in severity of pneumonia, etc., even after viral infection.
7.WO/2022/165121METHODS FOR DETECTING A PANEL OF VIRUSES CAUSING RESPIRATORY ILLNESS
WO 04.08.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/US2022/014230 Applicant AVELLINO LAB USA, INC. Inventor CHAO-SHERN, Connie
The present invention provides compositions and methods for detecting and treating respiratory illness. The methods and compositions described herein comprise at least one probe that may hybridize with a target nucleotide molecule. The target nucleotide molecule may be a part of a virus, which in turn may be present in a subject, such as a human subject.
8.WO/2022/158067REPLICON DNA, CLONING VECTOR, CLONING VECTOR PRODUCTION METHOD, SCREENING KIT, AND SCREENING METHOD
WO 28.07.2022
Int.Class C12N 7/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
Appl.No PCT/JP2021/039373 Applicant KAGOSHIMA UNIVERSITY Inventor IKEDA Masanori
This replicon DNA includes: a CMV promoter sequence that functions in vertebrate cells; a non-structural region that is positioned on the 3' side from the CMV promoter sequence and includes non-structural protein genes 1a and 1b from SARS-CoV-2; and the N gene from SARS-CoV-2, which is positioned on the 3' side from the non-structural region.
9.114767843一种以腮腺炎病毒为活载体的新型冠状病毒疫苗
CN 22.07.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202210709119.0 Applicant 北京赛尔富森生物科技有限公司 Inventor 安祺
本发明涉及一种以腮腺炎病毒为活载体的新型冠状病毒疫苗,属于生物医药技术领域。本发明提供了一种以腮腺炎病毒为活载体的新型冠状病毒疫苗,所述疫苗以腮腺炎病毒为活载体表达新型冠状病毒表面的糖蛋白、新型冠状病毒表面糖蛋白的功能亚基或者新型冠状病毒表面糖蛋白功能亚基的受体蛋白;所述疫苗可以作为二联苗进行使用,同时预防腮腺炎病毒和SARS‑CoV‑2。
10.114774425一种基于工程大肠杆菌的MERS-CoV病毒检测系统
CN 22.07.2022
Int.Class C12N 15/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
Appl.No 202210286335.9 Applicant 东北大学 Inventor 黄永业
本发明公开了一种基于工程大肠杆菌的MERS‑CoV病毒检测系统,属于基因工程领域,该工程菌包括PmrA/PmrB双组分系统和LuxI/LuxR群体感应系统;其中,所述PmrA/PmrB双组分系统的跨膜蛋白PmrB的胞外部分替换为待测病毒识别蛋白的受体;本发明根据冠状病毒通过表面刺突蛋白与人体细胞表面受体结合介导进一步感染的感染机制,以大肠杆菌为底盘菌,选用沙门氏菌中的PmrA/PmrB双组分系统和革兰氏阴性菌中的LuxI/LuxR群体感应系统构建工程大肠杆菌以检测冠状病毒,使其可以识别MRES‑CoV的刺突蛋白并发出荧光信号,并对其做安全防护处理使其可以实现病毒的检测。