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Analysis

1.WO/2022/165863IN-VITRO ENDOTHELIAL CELL CULTURE SYSTEM FOR OPTIMIZING PULSATILE WORKING MODES OF CONTINUOUS-FLOW ARTIFICIAL HEART
WO 11.08.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/CN2021/077163 Applicant DALIAN UNIVERSITY OF TECHNOLOGY Inventor WANG, Yu
An in-vitro endothelial cell culture system for optimizing pulsatile working modes of a continuous-flow artificial heart, relating to the technical field of artificial organs. The system comprises three parts: 1) a cell culture cavity on a microfluidic chip and an off-chip multi-component aortic arch afterload fluid mechanic circulation loop; 2) a device for simulating a cardiovascular system power source: a fluid loading device is implemented by a pulsatile blood pump, and an artificial heart device is connected in parallel across two ends of the pulsatile blood pump; and 3) a peripheral detection and feedback control system, comprising pressure and flow sensors, a fluorescence microscope, a high-speed CCD camera system, and a proportional-integral-derivative feedback control system. The system can accurately simulate real hemodynamic microenvironments of vascular endothelial cells at different parts of the aortic arch, and provides a miniature, objective, standard, and quantitative experimental platform for studying quantitative relationships between different pulsatile working modes of the pump speed of an artificial heart and hemodynamic signals in the local arterial endothelial microenvironment.
2.WO/2022/168774ESTIMATION DEVICE, LEARNING DEVICE, OPTIMIZATION DEVICE, ESTIMATION METHOD, LEARNING METHOD, AND OPTIMIZATION METHOD
WO 11.08.2022
Int.Class G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Appl.No PCT/JP2022/003522 Applicant SHIMADZU CORPORATION Inventor SUZUKI, Takashi
This estimation device (200) generates quality prediction data (540) representing the quality of a drug substance for a biopharmaceutical manufactured through culturing cells by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance within a culturing vessel at at least one timing after a specified interval has passed since seeding the cells in a culture medium. The prediction model (420) is generated by executing learning processing using data for learning (530) including measurement data that includes measurement results obtained by measuring the substance within the culturing vessel at a plurality of timings after seeding the cells in the culture medium, and quality data obtained by analyzing the drug substance for a biopharmaceutical manufactured from the cells.
3.WO/2022/169383METHOD FOR ISOLATING MICROVESICULES FROM PLANTS OF THE AMARANTHACEAE FAMILY
WO 11.08.2022
Int.Class A61K 36/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
Appl.No PCT/RU2022/000020 Applicant GORDEYCHUK, Vladimir Evgenevich Inventor POSPELOV, Vadim Igorevich
The invention relates to a method for isolating biologically active substances from raw plant matter, and more particularly to methods for obtaining microvesicules (with a diameter of 50-1200 nm) from plants of the Amaranthaceae family. The claimed method can be used in the medical, cosmetic and food industries. The technical result of the proposed method for isolating microvesicules is the possibility of isolating microvesicules from plants of the Amaranthaceae family. This technical result is achieved using a method for isolating microvesicules that involves collecting plants of the Amaranthaceae family, grinding same to produce a homogeneous mixture, then removing the liquid fraction from said mixture using a coarse filter, subsequently centrifuging said liquid fraction for 30 minutes at 3000 g and for 60 minutes at 10000 g, then ultracentrifuging the separated supernatant for 90 minutes at 150000 g, then suspending the resulting precipitate in a sodium phosphate buffer in a ratio of 1:10, ultracentrifuging again for 90 minutes at 150000 g, and again suspending the resulting precipitate in a sodium phosphate buffer in a ratio of 1:10, then filtering using a filter with a pore diameter of 1.2 μm.
4.WO/2022/170149MAGNETICALLY COUPLED COLLECTING SYSTEM FOR FLOW CYTOMETRY AND CELL SORTER SYSTEMS
WO 11.08.2022
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
Appl.No PCT/US2022/015383 Applicant CYTEK BIOSCIENCES, INC. Inventor HONARYAR, Babak
A collecting system with a magnetically coupled sample mover is provided for flow cytometry and cell sorter systems. The collecting system uses magnets in a driver carriage to control the position of other magnets in a follower carriage. The driver carriage can thereby control the position of the follower carriage without physically touching the follower carriage.
5.20220252445LIQUID SURFACE DETECTION DEVICE, ATOMIZATION DEVICE, AND CULTURE DEVICE
US 11.08.2022
Int.Class G01F 23/30
GPHYSICS
01MEASURING; TESTING
FMEASURING VOLUME, VOLUME FLOW, MASS FLOW, OR LIQUID LEVEL; METERING BY VOLUME
23Indicating or measuring liquid level, or level of fluent solid material, e.g. indicating in terms of volume, indicating by means of an alarm
30by floats
Appl.No 17724109 Applicant PHC Holdings Corporation Inventor Yuta SAKAI

This liquid surface detection device comprises: a liquid retention part in which hydrogen peroxide water is retained, the hydrogen peroxide water to be atomized by a vibrating plate in which a through-hole is provided; a float positioned inside the liquid retention part; and a sensor that detects, via the float, the arrival of the liquid surface of the hydrogen peroxide water retained in the liquid retention device at a prescribed position.

6.WO/2022/167510METHOD FOR HANDLING BIOLOGICAL CELL CULTURES
WO 11.08.2022
Int.Class G01N 35/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
02using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
04Details of the conveyor system
Appl.No PCT/EP2022/052551 Applicant AIXINNO LIMITED Inventor GILLIGAN, Patrick Clemente
The invention relates to a method for handling supports (1-9) which support biological cell cultures or auxiliary agents for treatment of biological cell cultures, using one or more modules (12-14), at least one of which is a handling device (22). Each one of a plurality of supports (1-9) rests with its edges on support elements (21), and, depending on the type of supports or the type of auxiliary means supported thereby, the supports (1-9) require different storage heights (H1-H7), some of which are greater than one or more times a standardised vertical spacing (A) of the support elements (21). The supports (1-9) have an information carrier (11), the information of which can be read by a reading device (24) and can be evaluated by a computing device (16). For optimal use of the compartments of the storage device, according to the invention, the information contains details about the storage height (H1-H7) of the support (1-9) in question and the handling of the supports (1-9) is performed using these details. Furthermore, the invention relates to a device for carrying out the method, and to a support for carrying out the method or for use in the device.
7.20220251497MICROFLUIDIC CHIP SUITABLE FOR CAPTURING CIRCULATING TUMOUR CELLS
US 11.08.2022
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No 17628575 Applicant PEKING UNIVERSITY Inventor Gen YANG

A microfluidic chip capable of being used for capturing target particles, the chip comprising a convergence and shunt unit, the convergence and shunt unit being capable of converging target particles in a liquid sample to the centre of a liquid flow, and simultaneously splitting off a certain proportion of the liquid flow that does not contain target particles, thereby effectively reducing the flow and speed of the liquid flow inputted to the chip; when used for capturing target particles, the chip also comprises a capturing unit, and implements capture of the target particles by means of the capturing unit.

8.WO/2022/167676USE OF 3D POROUS STRUCTURE FOR PLATELET PRODUCTION
WO 11.08.2022
Int.Class C12M 3/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
04with means providing thin layers
Appl.No PCT/EP2022/052946 Applicant HEMOSTOD SA Inventor DAHAN, Elodie
A method and device for large-scale platelet production in vitro are provided. The method uses a platelet production device comprising a rotatable bed reactor configured to contain a porous material for producing platelet from megakaryocytes at large scale.
9.WO/2022/167647CELL CULTURE MEMBRANE STRUCTURE, METHODS FOR PRODUCING THE SAME, CELL CULTURE PLATE AND MICROFLUIDIC DEVICE USING THE SAME
WO 11.08.2022
Int.Class C12M 1/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
32multiple field or continuous type
Appl.No PCT/EP2022/052859 Applicant FINNADVANCE OY Inventor SINGH, Prateek
The present disclosure refers to a porous membrane structure that can be used as a cell culture support adapted for specific cells to be grown thereon. The porous membrane structure comprises a membrane having through pores formed therein and at least one coating layer provided on the membrane such that the through pores remain open. Said adaptation is provided by selecting membrane and coating materials based on at least one type of cells to be grown on the at least one coating layer. By so doing, it is possible to alter different properties of the cell culture membrane structure (e.g., chemical and physical properties, such as hydrophilicity/hydrophobicity, stiffness, roughness, cell proliferation, attachment, mobility, survivability, etc.), thereby providing control over how a cell interacts with the membrane and other cells.
10.WO/2022/166965CELL NICHE ENGINEERING PLATFORM, MULTIPLEXED BIOCHIPS RESULTING THEREFROM AND METHODS OF USE THEREOF
WO 11.08.2022
Int.Class C40B 40/00
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
Appl.No PCT/CN2022/075402 Applicant THE UNIVERSITY OF HONG KONG Inventor CHAN, Pui Barbara
Provided are cell niche engineering platform which represents a valuable in vitro tool for investigating physiological and pathological cellular activities, an all-in-one technology to engineer cell niche (particularly soluble cell niche factors) with retained bioactivities, a mask-free, non-contact, biocompatible and multiphoton-based microfabrication and micropatterning method for engineering a spatially and quantitatively controllable soluble proteins/bioactive factors and cell-cell adhesion molecules. An universal cell niche engineering platform is provided that contributes to reconstituting heterogeneous native soluble cell niche for signal transduction modeling and drug screening studies.