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Analysis

1.20220252574IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USING
US 11.08.2022
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Appl.No 17629309 Applicant University of Louisville Research Foundation, Inc. Inventor Kevin Joseph Sokoloski

Immunomodulatory compositions that include at least one alphavirus capsid protein and methods of using such immunomodulatory compositions. In one aspect, methods of immunomodulating IL-1/TLR signaling in a cell are provided. Such methods typically include contacting the cell with an alphavirus capsid protein or a portion thereof, thereby immunomodulating IL-1/TLR signaling in the cell.

2.20220251048TEAD INHIBITORS AND USES THEREOF
US 11.08.2022
Int.Class C07D 233/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
56with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
58with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
Appl.No 17646787 Applicant Ikena Oncology, Inc. Inventor Alfredo C. CASTRO

The present invention provides compounds, compositions thereof, and methods of using the same.

3.20220251078Continuous Process for the Preparation of Anticholinergic Drugs
US 11.08.2022
Int.Class C07D 453/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
Appl.No 17617725 Applicant Hovione Scientia Limited Inventor Marianna KATZ

The present invention relates to a novel process for the preparation of anticholinergic agents/drugs, such as umeclidinium bromide, tiotropium bromide, glycopyrronium bromide, aclidinium bromide, ipratropium bromide (V) in continuous flow mode in the presence of one or more polar protic solvents. The anticholinergic drugs are in a form suitable for use in inhalation in the treatment of respiratory diseases such as asthma or chronic obstructive pulmonary disease (COPD).

4.20220249473A NOVEL THERAPY FOR ERYTHROPOIETIC PROTOPORPHYRIA (EPP) AND X-LINKED PROTOPORPHYRIA (XLP)
US 11.08.2022
Int.Class A61K 31/4985
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
Appl.No 17612638 Applicant Xiaochao MA Inventor Xiaochao MA

Disclosed are novel compositions and methods of using the same for the treatment of Erythropoiefic protoporphyria (EPP) and X-linked protoporphyria (XLP). Disclosed are methods and compositions related to treating Erythropoietic protoporphyria and X-linked protoporphyria. Also described are therapeutic agents that can inhibit ABCG2. For example, provided herein are therapeutic agents defined by Formula I.

5.20220249557Vaccine and Uses thereof in Cell Therapy
US 11.08.2022
Int.Class A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Appl.No 17592601 Applicant Innovative Cellular Therapeutics Holdings, Ltd. Inventor Yang Li

The present disclosure relates to compositions and methods for enhancing T cell response in vivo. For example, a method of enhancing T cell response in a subject or treating a subject having cancer, the method comprising: administering an effective amount of a composition comprising modified cells to the subject having a form of cancer associated with or expressing an antigen, for example, a solid tumor antigen; and administering (1) a nucleic acid encoding the antigen, (2) additional modified cells comprising the nucleic acid or the antigen, or (3) microorganisms, for example cold viruses, comprising the nucleic acid or the antigen. In embodiments, the modified cells comprise mixed cells targeting a solid tumor antigen and a white blood cell (WBC) antigen. In embodiments, the modified cells comprise a dominant negative form of an immune checkpoint molecule (e.g., PD-1). In embodiments, the modified cells comprise an exogenous polynucleotide encoding a therapeutic agent, such as IL-12 and IFNγ.

6.WO/2022/165803PRODUCTION APPARATUS AND PRODUCTION METHOD FOR SUCROSE-6-ESTER
WO 11.08.2022
Int.Class B01D 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
Appl.No PCT/CN2021/075813 Applicant ANHUI JINHE INDUSTRIAL CO., LTD. Inventor ZHANG, Zhengsong
A production apparatus and a production method for sucrose-6-ester, the apparatus comprising a tank, a rotary distillation device, and a condensing device, wherein the tank comprises a separation cavity and a reaction cavity, the condensing device is sleeved in the rotary distillation device, and the rotary distillation device is slidably connected in the separation cavity; a turntable for rotary distillation is fixed on a top surface of a rotating drum by a plurality of connecting plates, and a first heating device is provided on an outer wall of the turntable; the condensing device comprises a condensing pipe, a water-receiving plate and a water-condensing water tank, which are vertically connected in sequence; the condensing device is sleeved in the rotating drum of the rotary distillation device in a non-contact manner, and the condensing pipe runs through the turntable to be in contact with a top surface of the tank; and the rotary distillation device can rotate about a central axis of the turntable, so as to separate a reaction liquid entering from a reaction liquid feed pipe into steam and residual liquid after distillation. The apparatus realizes continuous production of sucrose-6-ester, greatly shortens the production cycle and improves the production efficiency.
7.WO/2022/165608ANTI-SYNUCLEINOPATHY PEPTIDE AND METHODS TO TREAT NEURODEGENRATIVE DISEASES
WO 11.08.2022
Int.Class A61K 47/66
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
66the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
Appl.No PCT/CA2022/050175 Applicant UNIVERSITY OF BRITISH COLUMBIA Inventor WANG, Yu Tian
Disclosed is a method of treating a neurodegenerative disease such as Parkinson's disease, diffuse Lewy body disease, transitional Lewy body dementia, and multiple system atrophy in a subject. The method comprises administering to the subject a therapeutically effective amount of a peptide comprising an α-synuclein binding domain operably linked to a protein transduction domain and a proteasomal targeting domain, wherein the α-synuclein binding domain is derived from a reversed sequence of β-synuclein. Other methods, as well as uses and compositions, are disclosed.
8.WO/2022/165623METHOD FOR PREPARING 1,1,1,3-TETRACHLOROPROPANE
WO 11.08.2022
Int.Class C07C 17/275
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
17Preparation of halogenated hydrocarbons
26by reactions involving an increase in the number of carbon atoms in the skeleton
272by addition reactions
275of hydrocarbons and halogenated hydrocarbons
Appl.No PCT/CN2021/074800 Applicant NINGBO INSTITUTE OF MATERIALS TECHNOLOGY & ENGINEERING, CHINESE ACADEMY OF SCIENCES Inventor ZHANG, Yexin
Disclosed is a method for preparing 1,1,1,3-tetrachloropropane, comprising: reacting the raw materials containing carbon tetrachloride and ethylene in the presence of a first catalyst and a second catalyst to obtain the 1,1,1,3-tetrachloropropane, wherein the first catalyst comprises a carrier and an active component supported on the carrier; the active component comprises nano zero-valent iron; and the second catalyst comprises an ester compound. A supported iron catalyst is used in the preparation method, which can significantly improve the problem of easy agglomeration when only commercially available iron powder is used as a catalyst, and can also increase the specific surface area of the iron, which is conducive to the progress of the reaction.
9.WO/2022/165578ADDITIVE FOR PRESERVING CELLS, TISSUE AND/OR FOODSTUFFS, AND USE
WO 11.08.2022
Int.Class A01N 3/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
3Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves; Grafting wax
02Keeping cut flowers fresh chemically
Appl.No PCT/BR2022/050037 Applicant PROTEIMAX BIO TECHNOLOGY ISRAEL LTD Inventor HEIMANN, Andrea Sterman
The present invention pertains to the fields of biotechnology, phytochemistry and food technology, and provides an additive for preserving cells, tissue and/or foodstuffs and the use of a synthetic peptide for preparing said additive. Among other applications, the invention is useful for increasing the shelf life of foodstuffs and providing greater food safety. In one embodiment, the additive of the invention provides substantial preservation of fruit through a single application of the additive, providing the treatment of plants or foodstuffs in order to prevent the occurrence of blight such as bacteria or fungi such as, for example, those related to the rotting of fruit, including strawberries, and Xylella fastidiosa in coffee plants and orange groves. In one embodiment, the additive of the invention provides substantial preservation of flowers or inflorescences through a single application of the additive, providing an alternative against the rapid wilting, rotting or appearance of fungi associated with the storage, transport and/or medicinal processing of flowers or inflorescences of phytochemical interest, including gerbera and cannabis, inter alia. In one embodiment, the present additive provides substantial preservation of the metabolic state of shoots or seedlings, in addition to delaying the seed germination process when said additive is applied, and is therefore useful for synchronizing germination and adjusting the moment of planting or germination, among other agricultural or botanical advantages.
10.WO/2022/166748COMPOUND FOR TREATING OR PREVENTING VIMENTIN-MEDIATED DISEASES
WO 11.08.2022
Int.Class C07D 251/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
251Heterocyclic compounds containing 1,3,5-triazine rings
02not condensed with other rings
12having three double bonds between ring members or between ring members and non-ring members
14with hydrogen or carbon atoms directly attached to at least one ring carbon atom
16to only one ring carbon atom
18with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
Appl.No PCT/CN2022/074275 Applicant LUODA BIOSCIENCES, INC. Inventor WU, Jianping
Provided in the present invention is a compound for treating or preventing vimentin-mediated diseases. The compound of the present invention is a s-triazine derivative, as shown in the following formula A, or a pharmaceutically acceptable carrier, prodrug, enantiomer, diastereomer, tautomer or solvate thereof, wherein R1, R2 and Z are as defined herein. The present invention further comprises the corresponding pharmaceutical use, and a method for treating and preventing diseases.