A method for treating a patient with a neurodegenerative disease including performing Ketamine Infusion Therapy on the patient, performing hyperbaric oxygen therapy on the patient, intranasally infusing plasma into the patient, and intranasally infusing diluted insulin into the patient. Performing hyperbaric oxygen therapy on the patient may include placing the patient into a hyperbaric chamber, sealing and pressurizing the hyperbaric chamber, and pumping oxygen into the hyperbaric chamber while it is pressurized. Before intranasally infusing plasma into the patient, the method may include drawing blood from the patient and centrifugally extracting the plasma from the drawn blood, such as platelet rich plasma (PRP). Before drawing blood from the patient, the method may include intravenously injecting the patient with supplements, such as a combination of magnesium, calcium, B-vitamins, Vitamin C, nicotinamide adenine dinucleotide (NAD+), and Glutathione.

A dressing or a tissue interface for treating a tissue site with negative pressure may comprise a fluid control layer, a base manifold, and a closure manifold layer. The fluid control layer may comprise a plurality of fluid restrictions, and the base manifold may be disposed adjacent to the fluid restrictions. The closure manifold may have perforations adjacent to the base manifold layer. Additionally, the base manifold layer may have a first density, and the closure manifold layer may have a second density, wherein the second density is less than the first density. The closure manifold may be configured to deform laterally at a second negative pressure that is less than the first negative pressure.