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Analysis

1.20220249398Cannabinoid Formulation Containing Active Ingredients and Carrier for Transdermal Absorption to Treat Neuropathy
US 11.08.2022
Int.Class A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
Appl.No 17704318 Applicant William Seidel Inventor William Seidel

The invention relates to a topical formulation in order to deliver an effective amount of broad-spectrum cannabidiol ointment, in conjunction with active ingredients, menthol and camphor. This invention is for the treatment of symptoms and improvement of sensation associated with peripheral neuropathy, particularly of the feet and hands. The present invention also provides for various topical application formulations.

2.20220249583NOVEL LACTIC ACID BACTERIA STRAIN - ANTIBACTERIAL PEPTIDES PRODUCED BY SAID STRAIN AND RELATED PHARMACEUTICAL COMPOSITIONS
US 11.08.2022
Int.Class A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
Appl.No 17616156 Applicant UNIVERSITE DE LILLE Inventor RABAH BOUKHERROUB

A Lactobacillus paracasei strain deposited at the CNCM under reference number CNCM I-5369. A mixture of the peptides having the following sequences: (SEQ ID NO 1), (SEQ ID NO 2), (SEQ ID NO 3), (SEQ ID NO 4) and (SEQ ID NO 5) and to one of the above-mentioned peptides in combination with at least one component chosen among: essential oils and particularly among essential oil of mint, essential oil of thyme, essential oil of pine tree, menthol, thymol, pinene, vitamin C, formic acid, propionic acid, citric acid, sorbic acid and lactic acid and/or a nanoparticle which may be loaded with said active ingredients.

3.102021102873VERFAHREN ZUR HERSTELLUNG VON TREMELLA ZUSAMMENSETZUNG UND TREMELLA ZUSAMMENSETZUNG
DE 11.08.2022
Int.Class A61K 36/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
06Fungi, e.g. yeasts
07Basidiomycota, e.g. Cryptococcus
Appl.No 102021102873 Applicant WELLYOUTH BIOTECH CO., LTD. Inventor Li Yu-Cheng

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung einer Tremella-Zusammensetzung, bestehend aus einem Tremella-Dehydrierungsschritt zur Dehydrierung frischer Tremella, einem ersten Mahlvorgang zum Mahlen der dehydrierten Tremella, einem zweiten Mahlvorgang zum Mahlen von Ballaststoffen, einem ersten Mischschritt zur Zugabe von Stärke zu den gemahlenen Ballaststoffen für eine gleichmäßige Mischung, einem zweiten Mischschritt zur Zugabe von Ballaststoffen zu gemahlener Tremella und Protein, einem dritten Mischschritt der Zugabe von Nukleinsäurelösung zur Tremella, von Protein- und Ballaststoffen, einem Abkochungsschritt zur Erwärmung der oben genannten gemischten Tremella, mit Protein- und Ballaststoffgehalt für eine vorbestimmte Zeit, einem PH Einstellungsschritt zur Anpassung des pH-Wertes der genannten Tremella, mit Protein- und Ballaststoffgehalt nach dem Erhitzen, um die Tremella-Zusammensetzung zu erhalten, und einem Nachweisschritt zum Nachweis der menschlichen Zellreparaturwirkung der Tremella-Zusammensetzung. embedded image

4.WO/2022/166839USE OF GINKGO LEAF EXTRACT IN PREPARATION OF DRUG FOR TARGETING SENESCENT CELLS, INHIBITING TUMORS OR PROLONGING LIFETIME
WO 11.08.2022
Int.Class A61K 36/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
Appl.No PCT/CN2022/074740 Applicant BY HEALTH CO LTD Inventor SUN, Yu
The use of a ginkgo leaf extract (GLE) in the preparation of a drug for targeting senescent cells, inhibiting tumors or prolonging lifetime. The ginkgo leaf extract, which targets a tumor microenvironment and eliminates senescent cells, can promote tumor suppression by means of eliminating senescent stromal cells after combination with a chemotherapy drug. For a senescence-associated secretory phenotype (SASP), the GLE can also eliminate senescent cells therein in a targeted manner, thereby inhibiting the SASP. The GLE can further significantly prolong the lifetime of an animal, significantly prolong the survival time of the elderly, and improve the survival quality of an animal.
5.WO/2022/166599NEW USE OF PQQ AND DERIVATIVE THEREOF
WO 11.08.2022
Int.Class C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/CN2022/072881 Applicant GUANGZHOU HUTONGYOUWU BIOTECHNOLOGY CO., LTD Inventor GUO, Ling
A new use of PQQ and a derivative thereof. PQQ can effectively alleviate or treat primary dysmenorrhea, secondary dysmenorrhea and abnormal menstruation. After being treated with PQQ, the following effects can be achieved for patients: 1. the dysmenorrhea alleviation rate is 100%; 2. the average duration of a menstrual period in each month is reduced from about 2 weeks to about 1 week, and is returned to the normal average duration of a menstrual period; 3. the menstrual blood volume in each month is reduced by more than 30% on average, and is substantially returned to the normal average level of menstrual blood volume; and 4. two patients suffering from years of infertility caused by secondary dysmenorrhea are pregnant within a treatment period of 3 months.
6.20220249368HEAT RESISTANT CHEWABLE ORAL FORM WITH AN AGAR MATRIX AND MANUFACTURING PROCESS THEREOF
US 11.08.2022
Int.Class A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
Appl.No 17636526 Applicant PROCAPS S.A. Inventor Andrea Ocampo Salgado

The present invention defines a process for forming a chewable oral dosage form, such as a gum having a pleasant flavor and texture. In particular, the invention includes a process of forming an oral dosage form, comprising: a first step of hydrating a gelling agent of agar-agar and locust bean gum; a second step of mixing in components of the agar matrix; a third step of mixing in an active ingredient; a fourth step of cooking the mixture; a fifth step of flavoring; a sixth step of moulding and gelling; and a seventh step of demoulding, degreasing and drying. The oral dosage form according to the invention also comprises an agar-agar matrix combined with gums, such as locust bean gum, and/or sugar; glycerol; inulin; flavoring agents; citric acid; a coating; and water, to complete the composition, which includes active ingredients.

7.WO/2022/168123PROCESS FOR PREPARING NANOFORMULATION FOR DELIVERY OF BERBAMINE
WO 11.08.2022
Int.Class A61K 36/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Appl.No PCT/IN2022/050103 Applicant PANJAB UNIVERSITY, CHANDIGARH Inventor VASISHT, Karan
The present invention relates to a simple and convenient process for preparing solid lipid sustained release nanoparticles for berbamine delivery. The process involves preparation of nanoparticles by maintaining the pH of the aqueous or lipid phase so that high drug loading of 12-50 % w/w with respect to the lipid matrix and high entrapment efficiency of more than 90% for berbamine in the solid lipid nanoparticles is achieved. The nanoformulation obtained by the process of the present invention has increased efficacy and exhibited any therapeutic property identical to free berbamine such as antiviral-cum-antibacterial agent for the treatment of microbial infections especially resistant Acinetobacter infections in treating diabetes and more specifically diabetes associated complications. Use may be extended to other diseases like COVID 19.
8.WO/2022/169383METHOD FOR ISOLATING MICROVESICULES FROM PLANTS OF THE AMARANTHACEAE FAMILY
WO 11.08.2022
Int.Class A61K 36/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
Appl.No PCT/RU2022/000020 Applicant GORDEYCHUK, Vladimir Evgenevich Inventor POSPELOV, Vadim Igorevich
The invention relates to a method for isolating biologically active substances from raw plant matter, and more particularly to methods for obtaining microvesicules (with a diameter of 50-1200 nm) from plants of the Amaranthaceae family. The claimed method can be used in the medical, cosmetic and food industries. The technical result of the proposed method for isolating microvesicules is the possibility of isolating microvesicules from plants of the Amaranthaceae family. This technical result is achieved using a method for isolating microvesicules that involves collecting plants of the Amaranthaceae family, grinding same to produce a homogeneous mixture, then removing the liquid fraction from said mixture using a coarse filter, subsequently centrifuging said liquid fraction for 30 minutes at 3000 g and for 60 minutes at 10000 g, then ultracentrifuging the separated supernatant for 90 minutes at 150000 g, then suspending the resulting precipitate in a sodium phosphate buffer in a ratio of 1:10, ultracentrifuging again for 90 minutes at 150000 g, and again suspending the resulting precipitate in a sodium phosphate buffer in a ratio of 1:10, then filtering using a filter with a pore diameter of 1.2 μm.
9.102021103181Eine traditionelle chinesische Arzneimittelzusammensetzung zur Behandlung von rheumatischen Erkrankungen
DE 11.08.2022
Int.Class A61K 36/756
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
75Rutaceae (Rue family)
756Phellodendron, e.g. corktree
Appl.No 102021103181 Applicant Shanghai Jishuai Bio Technology CO., LTD Inventor Li Qiaosheng

Die vorliegende Erfindung stellt eine traditionelle chinesische Arzneimittelzusammensetzung zur Behandlung von rheumatischen Erkrankungen zur Verfügung, dadurch gekennzeichnet, dass die traditionelle chinesische Arzneimittelzusammensetzung, bezogen auf das Gewicht, umfasst: 5-10 Teile Platycodon grandiflorum, 5-10 Teile Minze, 5-10 Teile Astragalus und 2-6 Teile Eucommia ulmoides, 2-6 Teile Phellodendron chinense, 2-6 Teile Weidenzweig. Verglichen mit den bestehenden traditionellen chinesischen Arzneimittelzusammensetzungen zur Behandlung rheumatischer Erkrankungen, haben die einzelnen chinesischen Arzneimittel der vorliegenden Erfindung eine gute Kompatibilität und eine ausgezeichnete therapeutische Wirkung nach der Kompatibilität. Die Pharmakodynamik der einzelnen Komponenten spielen eine synergistische Rolle, von denen die klinisch verifizierte therapeutische Wirkung gut ist, die heilende Wirkung langanhaltend ist und die Rückfallrate niedrig ist. Die traditionelle chinesische Arzneimittelzusammensetzung löst das Problem der rheumatischen Erkrankungen, die nicht über einen langen Zeitraum geheilt werden können.

10.WO/2022/168124BERBERIS EXTRACT NANO-FORMULATION AND PROCESS OF PREPARATION THEREOF
WO 11.08.2022
Int.Class A61K 36/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Appl.No PCT/IN2022/050106 Applicant PANJAB UNIVERSITY, CHANDIGARH Inventor KARAN, Maninder
The present invention relates to a process for extraction and freeze-drying of a Berberis extract. More particularly, the invention provides an optimized process for freeze-drying/ lyophilization to increase the solubility of the extract into the surfactants for enhanced incorporation into a nano-carrier system. Furthermore, the present invention also relates to a lipid nano-formulation of freeze-dried Berberis extract and process for preparing the same by high-pressure homogenization. The invention also relates to the lipid nano-formulation of freeze-dried Berberis extract for efficient drug delivery, for dermatological and cosmeceutical purposes, for treating diabetes and diabetes associated complications, as a wound healer, as an antimicrobial, as an anti-infective, as an anti-inflammatory agent and as an antioxidant.