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Analysis

1.20220307068GENE AMPLIFICATION CHIP, APPARATUS FOR GENE AMPLIFICATION, AND METHOD OF MANUFACTURING GENE AMPLIFICATION CHIP
US 29.09.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No 17356126 Applicant SAMSUNG ELECTRONICS CO., LTD. Inventor Won Jong JUNG

A gene amplification chip may include a substrate; a through-hole array including through-holes that extend from an upper surface of the substrate to a lower surface of the substrate and in which a gene amplification reaction occurs; and a photothermal film provided on at least one of the upper surface and the lower surface of the substrate and configured to generate heat using light.

2.20220307962Quadrature Phase Analysis Light Scattering for Electrophoresis and Zeta Potential Measurements
US 29.09.2022
Int.Class G01N 15/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
02Investigating particle size or size distribution
Appl.No 17807256 Applicant Robert Dickerman Inventor Robert Dickerman

Stationary devices employing quadrature phase analysis light scattering are provided, to aid in the determination of the magnitude and polarity of electrophoretic mobility and zeta potential of particles in colloids. The devices use an optical quadrature interferometer with an electrophoresis sample chamber containing sample particles undergoing electrophoresis, the optical quadrature interferometer being configured to generate a quadrature signal. The phase of the quadrature signal may be analyzed at the frequency of the sample chamber electric field to estimate displacements and directions of the particles. The estimates can be used to determine a central value of the magnitude of the electrophoretic mobility, as well as its polarity. Particles having low electrophoretic mobility, or that may be adversely affected by high electric fields, can be analyzed, and constraints on vibration and light source coherence length may be relaxed. A phase modulator or frequency shifter is not required.

3.20220308057METHOD FOR DETERMINING ONSET RISK OF CARDIOVASCULAR DISEASE IN SUBJECT, AND METHOD FOR DETERMINING VASCULAR CALCIFICATION IN SUBJECT
US 29.09.2022
Int.Class G01N 33/573
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
Appl.No 17675194 Applicant SYSMEX CORPORATION Inventor Maria KIRIYAMA

Disclosed is a method of determining onset risk of cardiovascular disease in a subject, the method comprising:

    • capturing, on a solid phase, an extracellular vesicle derived from a blood sample collected from the subject; and
    • measuring alkaline phosphatase activity of the extracellular vesicle,
    • a measured result of the alkaline phosphatase activity being directed for use as an index of the onset risk of cardiovascular disease in the subject.

4.20220308056BIOMARKER FOR ASSESSING THE RISK OF DEVELOPING ACUTE COVID-19 AND POST-ACUTE COVID-19
US 29.09.2022
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 17665176 Applicant Omeros Corporation Inventor Gregory A. Demopulos

Disclosed herein are compositions, kits and methods for determining the concentration of fluid-phase MASP-2/C1-INH complex in a biological fluid, such as a biological fluid obtained from a subject infected with SARS-CoV-2. Also disclosed are methods of using said compositions, methods and kits for detection of MASP-2/C1-INH complex to determine the status of lectin pathway activation in a mammalian subject and thereby assess the risk of a subject that is or has been infected with SARS-CoV-2 for developing COVID-19-related ARDS or other poor outcome, or determine the need for treatment or efficacy of treatment of a subject in need thereof with a complement inhibitor such as a MASP-2 inhibitory agent.

5.20220307961APPARATUS AND METHODS FOR THE QUALITATIVE AND QUANTITATIVE DETECTION OF AMPHIPHILES
US 29.09.2022
Int.Class G01N 13/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
13Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
02Investigating surface tension of liquids
Appl.No 17214431 Applicant EZRATERRA, LLC Inventor Patrick Richard BRADY

Methods, apparatus, and kits for detecting and optionally quantifying amphiphilic compounds in the environment, in media samples, and on objects by determining an initial surface energy of a surface of a sample substrate, exposing the sample substrate surface to a medium that contains or is suspected to contain an amphiphilic compound for a time sufficient for the amphiphilic compound to interact with the sample substrate surface, determining a post-exposure surface energy of the surface of the sample substrate, determining a change in the surface energy of the sample substrate surface, and correlating the determined change in surface energy of the sample substrate surface with a presence and/or character of amphiphilic compounds in the medium.

6.102021107754Sensorschaltung, elektrochemischer Sensor, sowie Verfahren zum Betreiben des elektrochemischen Sensors
DE 29.09.2022
Int.Class G01R 19/10
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
19Arrangements for measuring currents or voltages or for indicating presence or sign thereof
10Measuring sum, difference, or ratio
Appl.No 102021107754 Applicant Endress+Hauser Conducta GmbH+Co. KG Inventor Haase Björn

Die Erfindung betrifft eine Sensorschaltung (1) für einen elektrochemischen Sensor (2), umfassend: - eine Spannungsquelle (10), - eine Steuereinheit (20), welche mit der Spannungsquelle (10) verbunden ist, - einen ersten Impedanzwandler (30) mit einem Eingang (31) und einem Ausgang (32), - ein erstes Eingangsfilter (40) mit einem Eingang (AA) und einem Ausgang (BB), - einen ersten Anschluss (60) zum Anschließen eines Kabels (70), - einen zweiten Anschluss (61) zum Anschließen des Kabels (70), wobei der zweite Anschluss (61) mit dem Eingang (31) des ersten Impedanzwandlers (30) verbunden ist, wobei der Eingang (31) des ersten Impedanzwandlers (30) mit dem Eingang (AA) des ersten Eingangsfilters (40) verbunden ist. embedded image

7.102021107821Lichtblatt-Fluoreszenzmikroskop
DE 29.09.2022
Int.Class G02B 21/06
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
06Means for illuminating specimen
Appl.No 102021107821 Applicant Universität Kassel, Körperschaft des öffentlichen Rechts Inventor Aakhte Mostafa

Gegenstand der Erfindung ist ein Lichtblatt-Fluoreszenzmikroskop (100) zur tomographischen Darstellung einer Probe (P), insbesondere einer lebenden biologischen Probe, wenigstens umfassend eine Probenkammer (1), ein Beleuchtungssystem (110) mit einer Laserlichtquelle (2) zur sequenziellen Fluoreszenzanregung einzelner Probenschichten mittels wenigstens eines schichtweise verschiebbaren Lichtblatts (LB), und ein Abbildungssystem (120) zur sequenziellen Abbildung der Probenschichten auf einen Bildsensor (3) mittels aus der Probe (P) emittierter Fluoreszenzstrahlung (FS), wobei das Lichtblatt (LB) jeweils in die Brennebene wenigstens eines Abbildungsobjektiv (41, 42) des Abbildungssystems (120) einstrahlbar ist. Erfindungsgemäß weist das Beleuchtungssystem (110) zwei Beleuchtungsarme (111, 112) auf, über welche Paare von Lichtblättern (LB) von einander gegenüberliegenden Seiten der Probenkammer (1) in die jeweilige Probenschicht einstrahlbar sind, und wobei das Beleuchtungssystem (110) einen Lichtmodulator (5) zur räumlichen Modulation der Lichtblätter (LB) in der jeweiligen Probenschicht aufweist. embedded image

8.20220307960METHOD TO QUANTIFY THE EFFECTS OF DECOUPLING IN CORIOLIS METERS WITH BUBBLE COALESCENCE
US 29.09.2022
Int.Class G01N 9/32
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
9Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
32by using flow properties of fluids, e.g. flow through tubes or apertures
Appl.No 17656771 Applicant CORVERA LLC Inventor Daniel Gysling

Methods and apparatus are disclosed utilizing a low-order parametric model for decoupling in conjunction with an optimization procedure to improve the ability to determine the density of the liquid phase of a bubbly mixtures within Coriolis meters by characterizing the effect of decoupling in the presence of bubble coalescence.

9.20220306488METHODS, APPARATUS, AND SYSTEMS FOR DETECTING AND REMOVING MICROPLASTICS FROM WATER
US 29.09.2022
Int.Class C02F 1/00
CCHEMISTRY; METALLURGY
02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
1Treatment of water, waste water, or sewage
Appl.No 17701499 Applicant Aizaco Limited Company Inventor Carlos Alberto Hernandez Gutierrez

Methods, apparatus, and systems are provided for detecting and removing microplastics from wastewater effluent. Both, automatic/remote and manual monitoring and sampling components are included to detect the presence of microplastics. The automatic monitoring and sampling component includes a TSS sensor and associated apparatus calibrated to account for non-plastic solids present in the wastewater and, thereby, more accurately determine the presence of microplastics. Efficient separation and removal of microplastics from wastewater effluent is performed by a specialized capture net apparatus having multiple sized mesh components and optional diffuser devices which perform size exclusion filtration of microplastics from the water. In an exemplary embodiment, the methods generally include diverting treated wastewater effluent from a wastewater treatment facility's main line into a wastewater sampling mechanism via an intake pipe, and then into a solids monitoring and separation mechanism which includes the specialized capture net apparatus.

10.102022202725Optik-Messsystem, Optik-Messverfahren und Speichermedium, das darauf gespeichertes Messprogramm aufweist
DE 29.09.2022
Int.Class G01B 11/06
GPHYSICS
01MEASURING; TESTING
BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
11Measuring arrangements characterised by the use of optical means
02for measuring length, width, or thickness
06for measuring thickness
Appl.No 102022202725 Applicant Otsuka Electronics Co., Ltd. Inventor Kawaguchi Shiro

Ein Optikmesssystem 1A, 1B, 1C, 1D, 1E beinhaltet eine Lichtquelle 10, einen Spektroskopie-Detektor 20, eine Referenzprobe 60, 60S, einen Schaltmechanismus 32, 33, 84, der zwischen einem ersten optischen Pfad, durch welchen eine zu messende Probe 50 mit Licht aus der Lichtquelle bestrahlt wird, und an der Probe erzeugtes Licht zum Spektroskopie-Detektor geführt wird, und einem zweiten optischen Pfad, durch welchen die Referenzprobe mit Licht aus der Lichtquelle bestrahlt wird und das an der Referenzprobe erzeugte Licht zum Spektroskopie-Detektor geleitet wird, umschaltet, und eine Verarbeitungseinheit 200, die durch Durchführung von Korrekturverarbeitung 250 auf Basis einer Änderung zwischen einem ersten Detektionsergebnis 251 zu erster Zeit t0 und einem zweiten Detektionsergebnis 252 zu zweiter Zeit t1 einen Messwert der Probe aus einem dritten Detektionsergebnis 253 berechnet, das aus dem Spektroskopie-Detektor als ein Ergebnis der Bestrahlung der Probe mit Licht aus der Lichtquelle zu dritter Zeit t1' zeitlich nahe an der zweiten Zeit bereitgestellt wird. embedded image