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IC:C12Q1/68

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Analysis

1.WO/2022/207682IMMUNE CELL COUNTING OF SARS-COV-2 PATIENTS BASED ON IMMUNE REPERTOIRE SEQUENCING
WO 06.10.2022
Int.Class C12Q 1/6853
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6853using modified primers or templates
Appl.No PCT/EP2022/058362 Applicant F. HOFFMANN-LA ROCHE AG Inventor BERKA, Jan
The disclosure includes methods and compositions for accurately detecting subject's immune cell repertoire based on sequencing genomic DNA of immune cells.
2.WO/2022/207832CAPTURE CONSTRUCT AND METHOD FOR DETECTING A PLURALITY OF ANALYTES
WO 06.10.2022
Int.Class C12Q 1/6825
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6825Nucleic acid detection involving sensors
Appl.No PCT/EP2022/058640 Applicant LEICA MICROSYSTEMS CMS GMBH Inventor ALSHEIMER, Soeren
A capture construct (100, 1000) is provided for capturing a plurality of analytes (402, 504, 604, 706) of a biological sample (1300, 1408). The capture construct (100, 1000) comprises a nanostructure backbone (102), at least a first orientation indicator (104) and a second orientation indicator (106), and at least a first plurality of capture regions (108a-108f) on the nanostructure backbone (102), each capture region (108a-108f) comprising at least one affinity capture reagent (400, 502, 602, 702, 704) configured to capture one of the analytes (402, 504, 604, 706). In a further aspect a method is provided for detecting a plurality of analytes (402, 504, 604, 706) of a biological sample (1300, 1408).
3.WO/2022/208327SPATIAL MAPPING BY SERIAL PRIMER EXTENSION
WO 06.10.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/IB2022/052862 Applicant PIXELGEN TECHNOLOGIES AB Inventor FREDRIKSSON, Simon
Provided herein is probe system comprising: a population of nucleic acid molecules that have an extendible end, a first set of barcoded particles that each have a nucleotide sequence comprising: (i) a binding sequence that is complementary to the extendible end of the nucleic acid molecules, (ii) a unique particle identifier sequence, and (iii) a first template sequence, and a second set of barcoded particles that each have a nucleotide sequence comprising: (i) the first template sequence and (ii) a unique particle identifier sequence. In use, extension of the nucleic acid molecules using the first set of barcoded particles of as a template produces extensions products that contain the complement of a unique particle identifier sequence of a particle and the complement of the first template sequence. Methods of using the probe system to map binding events in or on a cellular sample are also provided.
4.WO/2022/209422METHOD FOR ESTIMATING PURIFIED STATE
WO 06.10.2022
Int.Class C07K 1/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
Appl.No PCT/JP2022/007006 Applicant FUJIFILM CORPORATION Inventor NAKAMURA, Naoki
This method for estimating a purified state comprises: quantifying components contained in a treated liquid obtained by subjecting a liquid containing a specific protein and contaminants other than protein to a purification treatment. The method for estimating a purified state comprises: obtaining an estimated value of the concentration of contaminants on the basis of spectral data indicating the wave number, or intensity for each wavelength, of electromagnetic waves that are emitted to a treated liquid and are then affected by the treated liquid. The concentration of contaminants contained in the treated liquid is at most 20 mg/mL, and the weight ratio of the contaminants with respect to a mixture containing protein and the contaminants is at most 15%.
5.WO/2022/212647PROTEIN-WIDE MODIFICATION OF ASPARTATES AND GLUTAMATES
WO 06.10.2022
Int.Class C07K 1/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
13Labelling of peptides
Appl.No PCT/US2022/022747 Applicant QUANTUM-SI INCORPORATED Inventor AD, Omer
The present disclosure is related to peptides comprising modified aspartic acid and glutamic acid moieties, methods of making such peptides, and methods of using such modified peptides to selectively direct cleavage of peptide bonds. Selective peptide bond cleavage is advantageous in peptide sequencing applications, such as automated peptide sequencing applications.
6.WO/2022/212872METHODS AND COMPOSITIONS FOR ACCELERATING OLIGODENDROCYTE MATURATION
WO 06.10.2022
Int.Class A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Appl.No PCT/US2022/023099 Applicant CASE WESTERN RESERVE UNIVERSITY Inventor TESAR, Paul J.
A method of accelerating cellular maturation is provided, the method including impairing the activity of developmental transcriptional condensates at an intermediate stage of a cell lineage. Specifically, Sox6 gene expression is inhibited to accelerate maturation of oligodendrocyte precursors, such as oligodrendrocyte progenitor cells (OPCs), into fully mature myelin-producing oligodendrocytes.
7.WO/2022/206661NUCLEIC ACID ISOTHERMAL AMPLIFICATION METHOD AND APPLICATION THEREOF
WO 06.10.2022
Int.Class C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
Appl.No PCT/CN2022/083311 Applicant HANGZHOU MATRIDX BIOTECHNOLOGY CO., LTD. Inventor HAN, Xu
Disclosed are a nucleic acid isothermal amplification method and an application thereof. a reverse transcriptase, an RNA polymerase, and an RNase H used in the method are all heat-resistant enzymes still active at at least 45 °C, and an amplification reaction is performed at a constant temperature of not less than 45 °C. The isothermal nucleic acid amplification method of the present invention has the characteristics of being rapid, isothermal, highly sensitive, and highly specific, and is suitable for nucleic acid detection in a field such as clinical testing.
8.WO/2022/208326ROLLING CIRCLE AMPLIFICATION PRODUCT HAVING MULTIPLE FREE ENDS
WO 06.10.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/IB2022/052861 Applicant PIXELGEN TECHNOLOGIES AB Inventor FREDRIKSSON, Simon
Described herein is a complex comprising multiple nucleic acid molecules that are hybridized together, each comprising, from 5' to 3', a first complementary sequence, a spacer sequence and a second complementary sequence, and either/or a 5' end sequence that is 5' of the first complementary sequence and terminates in a 5' phosphate and a 3' end sequence that is 3' of the second complementary sequence and terminates in a 3' hydroxyl. In this complex: the first complementary sequence of one molecule is directly or indirectly hybridized with the second complementary sequence of another molecule in the complex and the spacer sequence and the 3' and/or 5' end sequences are single-stranded. Methods of making and using the complex are also provided.
9.WO/2022/210066ANTIDRUG ANTIBODY MEASUREMENT METHOD
WO 06.10.2022
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/JP2022/012965 Applicant SEKISUI MEDICAL CO., LTD. Inventor SEKINO Tetsuo
Provided is a measurement method for antidrug antibodies that is easier and lower-cost compared with conventional methods. Provided is a double antigen bridging immunoassay method using a capture nucleic acid and a tracer nucleic acid. By using the capture nucleic acid and the tracer nucleic acid in the double antigen bridging immunoassay method, it is possible to measure antidrug antibodies easily and at a lower cost. Moreover, by using the tracer nucleic acid, it becomes possible to employ a nucleic acid–utilizing high-sensitivity detection method.
10.WO/2022/206922NUCLEOTIDE ANALOGUE FOR SEQUENCING
WO 06.10.2022
Int.Class C07H 19/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
10with the saccharide radical being esterified by phosphoric or polyphosphoric acids
Appl.No PCT/CN2022/084601 Applicant BGI SHENZHEN Inventor XU, Xun
The present invention relates to the field of nucleic acid sequencing. Specifically, provided in the present invention is a nucleotide analogue for sequencing. The nucleotide analogue carries a linker on the base or the ribose ring 3'-OH, and can be used for NGS sequencing. The present invention further relates to a kit containing the nucleotide analogue, and a sequencing method based on the nucleotide analogue.