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Analysis

1.20220307068GENE AMPLIFICATION CHIP, APPARATUS FOR GENE AMPLIFICATION, AND METHOD OF MANUFACTURING GENE AMPLIFICATION CHIP
US 29.09.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No 17356126 Applicant SAMSUNG ELECTRONICS CO., LTD. Inventor Won Jong JUNG

A gene amplification chip may include a substrate; a through-hole array including through-holes that extend from an upper surface of the substrate to a lower surface of the substrate and in which a gene amplification reaction occurs; and a photothermal film provided on at least one of the upper surface and the lower surface of the substrate and configured to generate heat using light.

2.20220307069HYBRID MANUAL-MACHINE LEARNING PCR CURVE ANALYSIS AND CLASSIFICATION
US 29.09.2022
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
Appl.No 17702573 Applicant QuantGene Inc. Inventor Johannes Bhakdi

Methods, systems and apparatus for the analysis of biological samples. Biological sample held in sample plates may be processed by a PCR machine. PCR curves are generated for each biological sample and analyzed by one or more machine learning models. The PCR curves are assigned a confidence level and classified based on the analysis and the confidence level. PCR curve with a confidence level below a predetermined threshold may be flagged for analysis by a lab director. PCR curves flagged for manual analysis may be displayed on an analysis interface. The lab director may view, analyze and classify the flagged PCR curves through interaction with the analysis interface.

3.WO/2022/200213DETECTION OF THE CLEAVAGE AND LIGATION ACTIVITY OF DNA TOPOISOMERASES
WO 29.09.2022
Int.Class C12Q 1/533
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
533involving isomerase
Appl.No PCT/EP2022/057172 Applicant VPCIR.COM APS Inventor TESAURO, Cinzia
The present invention relates to assays for determining the influence of an anti-topoisomerase 1B drug on the cleavage step and/or the ligation step of topoisomerase 1B enzymatic activity. The invention also relates to kits comprising such assays and uses thereof.
4.WO/2022/203543METHOD FOR REDUCING THE LEVELS OF EXPRESSION OF THE GENES LRNN3, GRAP, VAMP5
WO 29.09.2022
Int.Class A61K 36/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
Appl.No PCT/RU2022/000080 Applicant GORDEYCHUK, Vladimir Evgenevich Inventor POSPELOV, Vadim Igorevich
The invention relates to the field of gerontology, and more particularly to the possibility of acting on the expression profile of certain genes in human blood plasma which are associated with biological aging by administering an amaranth extract loaded into autologous exosomes, which makes it possible for this form of extract to be used as a protective agent against the effect of certain genetic factors in human blood plasma which are involved in the processes of biological aging of the body. The technical result of the claimed method is the possibility of reducing the levels of expression of the genes LRNN3, GRAP and VAMP5, the expression level of which rises as the biological age of the body increases, using autologous exosomes loaded with an amaranth extract. This technical result is achieved in that the claimed method includes consecutively carrying out the following steps: obtaining autologous exosomes; obtaining an amaranth extract (a commercial extract can be used); loading the obtained amaranth extract into the autologous exosomes; orally administering the loaded exosomes, diluted 1:10 in physiological solution, in an amount of 15 ml per 10 kg of body weight.
5.WO/2022/204173METHODS FOR PREDICTING TREATMENT OUTCOME TO CHECKPOINT INHIBITORS IN CANCER
WO 29.09.2022
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2022/021377 Applicant THE BRIGHAM AND WOMEN'S HOSPITAL, INC. Inventor MINEO, Marco
Described herein are methods of selecting a treatment for, and optionally treating, a subject who has a tumor and methods for determining is a subject who has a tumor is likely to benefit from an immunotherapy treatment. The methods disclosed herein can include the use of a long non-coding RNA, and/or a ribonucleoprotein, as biomarkers of patient response to immunotherapy treatment, such as an immune checkpoint inhibitor.
6.WO/2022/204023COMPOSITIONS AND METHODS FOR RAPID COVID-19 DETECTION
WO 29.09.2022
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/US2022/021138 Applicant DUKE UNIVERSITY Inventor SONG, Xin
The present disclosure provides compositions and methods related to the detection of pathogenic organisms. In particular, the present disclosure provides compositions and methods related to the detection and/or quantification of viral RNA in a sample from a subject that has, or is suspected of having, a SARS-CoV-2 infection. Using rapid reverse-transcription loop-mediated isothermal amplification (RT-LAMP), the compositions and methods of the present disclosure provide a portable, inexpensive, rapid, and accurate assay platform for detecting and/or quantifying the presence of a pathogenic organism (e.g., SARS-CoV-2) in a patient sample.
7.WO/2022/203093METHOD FOR DIAGNOSING OR PREDICTING CANCER OCCURRENCE
WO 29.09.2022
Int.Class G16H 50/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
Appl.No PCT/KR2021/003531 Applicant EONE DIAGNOMICS GENOME CENTER CO., LTD. Inventor KWON, Hyuk-Jung
The present invention relates to a method for diagnosing or predicting cancer and, specifically, to a method for diagnosing or predicting cancer, comprising steps in which: first analysis data on a cell-free DNA (cfDNA) concentration, second analysis data on copy number variation (CNV), and third analysis data on tumor marker expression amount are acquired; and a prediction unit uses a machine learning model trained to calculate a cancer occurrence probability through computing of the analysis data, so as to analyze the analysis data, and thus diagnose or predict cancer occurrence
8.20220305008TREATMENT OF CANCER HAVING GNAQ OR GNA11 GENETIC MUTATIONS WITH PROTEIN KINASE C INHIBITORS
US 29.09.2022
Int.Class A61K 31/497
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965Non-condensed pyrazines
497containing further heterocyclic rings
Appl.No 17420833 Applicant IDEAYA BIOSCIENCES, INC. Inventor John Knox

The present disclosure relates in part to methods for treating non-uveal melanoma cancers having GNAQ or GNA11 genetic mutations that include administering a PKC small molecule inhibitor.

9.WO/2022/198849HIGHLY SPECIFIC TAQ DNA POLYMERASE VARIANT AND USE THEREOF IN GENOME EDITING AND GENE MUTATION DETECTION
WO 29.09.2022
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
Appl.No PCT/CN2021/106566 Applicant SHANDONG UNIVERSITY Inventor HUANG, Qilai
Provided are a highly specific Taq DNA polymerase variant and the use thereof in genome editing and gene mutation detection. All polar amino acids, directly interacting with a primer/template complex, on a Taq enzyme are selected to be mutated one by one to obtain 40 Taq variants, and extensive random mutagenesis is performed on the basis of the sequences of the variants and the sequences of wild type Taq enzymes to create a Taq mutant library. Then, a series of Taq mutants with a high specificity are screened on a qPCR screening system by means of taking a genome editing indels plasmid as a template, wherein the Taq mutants exhibit great advantages in CRISPR/Cas9 editing efficiency evaluation and single-cell cloning genotyping.
10.WO/2022/198939B3 TRANSCRIPTION FACTOR GENE CAPABLE OF SIMULTANEOUSLY IMPROVING LENGTH, STRENGTH AND ELONGATION OF COTTON FIBERS AND APPLICATION OF GENE
WO 29.09.2022
Int.Class C12N 15/29
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
29Genes encoding plant proteins, e.g. thaumatin
Appl.No PCT/CN2021/118917 Applicant ZHEJIANG UNIVERSITY Inventor ZHANG, Tianzhen
A B3 transcription factor gene capable of simultaneously improving the length, strength and elongation of cotton fibers. A cDNA sequence of the transcription factor gene GHFLS in tetraploid upland cotton TM-1 is as shown in SEQ ID NO.1, and a genome sequence is as shown in SEQ ID NO.2; the gene GHFLS comprises a non-synonymous mutated SNP site which is located at the 1391bp position of a coding region sequence, the basic group of the SNP site is changed from A to G, and the corresponding amino acid is changed from Lys to Arg. The gene GHFLS is overexpressed in a model plant arabidopsis thaliana, it is found that the root length of T2-generation arabidopsis thaliana is remarkably shortened due to the overexpression of the gene, and it is proved that the gene plays an important role in a cell elongation mechanism. The fiber quality of a cotton variety (line) of a haplotype AA is remarkably superior to that of a cotton material of a haplotype GG. The gene has important research value and application prospect in efficient identification of high-quality fiber upland cotton varieties, improvement of cotton fiber quality characters, and cultivation of new high-quality fiber varieties of cotton.