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Analysis

1.WO/2022/200273METHODS FOR CYCLIZATION AND DE-CYCLIZATION OF LONG CHAIN GLYCOLIPIDS
WO 29.09.2022
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Appl.No PCT/EP2022/057351 Applicant PATHWAY INTERMEDIATES LIMITED Inventor GARNETT, David
A method for selective cyclization or de-cyclization of a mix of sophorolipids in the lactonic or acidic forms, wherein the lactonic form is produced by reacting a mixture of sophorolipids with a strong methylating agent to provide an end product having at least 70% w/w sophorolipids in their lactonic form; and wherein the acidic form is produced by reacting a mixture of sophorolipids with a genetically engineered enzyme having at least 50% homology to lipase B to provide an end product having at least 70% w/w sophorolipids in their acidic form.
2.20220307046PLANT CELL MATRICES AND METHODS THEREOF
US 29.09.2022
Int.Class C12N 15/82
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
Appl.No 17726141 Applicant Calyxt, Inc. Inventor Benjamin Campbell

Example embodiments in accordance with the present disclosure are directed to methods comprising contacting a plant part with a nucleotide sequence encoding a gene that induces plant cell matrix (PCM) formation, and culturing the plant part under growth conditions to enhance PCM formation.

3.WO/2022/204489MODIFIED ORGANISMS FOR ETHYLENE, ETHANE, AND METHANE BIOGENESIS AND METHODS FOR USE THEREOF
WO 29.09.2022
Int.Class C12N 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
Appl.No PCT/US2022/021905 Applicant OHIO STATE INNOVATION FOUNDATION Inventor NORTH, Justin
The present disclosure provides non-naturally occurring microbial organisms capable of producing ethylene, ethane, and/or methane, as well was methods for producing ethylene, ethane, and/or methane using the same.
4.WO/2022/202069METHOD FOR CULTURING MICROALGAE
WO 29.09.2022
Int.Class C12P 7/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
04acyclic
06Ethanol, i.e. non-beverage
Appl.No PCT/JP2022/007450 Applicant HONDA MOTOR CO., LTD. Inventor HIROSE Yoshitsugu
In an acquisition step of this method for culturing microalgae, a protein is obtained from microalgae cultured in a culture step. In a saccharification step, the protein obtained in the acquisition step is added as a saccharifying enzyme to a pressing residue that contains cellulose and that is obtained by pressing a biomass material, and the pressing residue is saccharified. In a fermentation step, a sugar obtained in the saccharification step and/or a sugar contained in pressed juice obtained by pressing the biomass material is fermented to produce a fermented product. In a culture step, carbon dioxide generated in the fermentation step is supplied to the microalgae.
5.WO/2022/199460ASPARTATE KINASE GENE EXPRESSION REGULATORY SEQUENCE AND USE THEREOF
WO 29.09.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/CN2022/081527 Applicant TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES Inventor SUN, Jibin
Disclosed are an aspartate kinase gene expression regulatory sequence and the use thereof. By modifying positions 366-373 of a sequence represented by SEQ ID NO: 1, a polynucleotide formed by linking the sequence with a start codon GTG or TTG has transcriptional expression regulation activity, and these polynucleotides can improve expression of the aspartate kinase encoding gene lysC, such that a large amount of L-lysine is accumulated.
6.WO/2022/203000FUSION PROTEIN BETWEEN ANTIGEN-BINDING MOLECULE AND STREPTAVIDIN VARIANT
WO 29.09.2022
Int.Class C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Appl.No PCT/JP2022/013994 Applicant THE UNIVERSITY OF TOKYO Inventor TANAKA Toshiya
The present invention addresses the problem of providing a fusion protein that is for use in treatment or diagnosis of cancer and that is formed between a streptavidin variant and a molecule that recognizes a cancer cell or the like. The present invention provides a fusion protein in which an antigen-binding molecule having a molecular weight of 20,000 or less is bound to, via a linker sequence, the N-terminal side and/or the C-terminal side of an amino acid sequence described in SEQ ID NO: 1 (wherein, the amino acid sequence of Pro-Ser-Ala-Ala-Ser His-His-His-His-His-His at the C-terminal may be partially or totally deleted).
7.WO/2022/202985PEPTIDE AND COMPOSITION CONTAINING PEPTIDE AS ACTIVE INGREDIENT
WO 29.09.2022
Int.Class C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Appl.No PCT/JP2022/013912 Applicant MORINAGA MILK INDUSTRY CO., LTD. Inventor OHINATA Kousaku
The present invention provides: a peptide that can be readily consumed on a daily basis and has various effects but few side effects; and a composition that contains the peptide as an active ingredient. Provided is a peptide that comprises the amino acid sequence of (a) or (b). (a) The amino acid sequence of SEQ ID NO:1 (Asn-Leu-Pro-Pro-Leu-Thr). (b) An amino acid sequence produced from the amino acid sequence of SEQ ID NO:1 by adding, deleting, or replacing one or more amino acids. Also provided is a composition that contains the peptide as an active ingredient.
8.20220306979METHOD FOR DETERMINING PROCESS VARIABLES IN CELL CULTIVATION PROCESSES
US 29.09.2022
Int.Class C12M 1/36
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
Appl.No 17670299 Applicant Hoffmann-La Roche Inc. Inventor Kristina Erhard

High throughput cultivation systems are used in pharmaceutical research and development. In this connection, samples are taken and analyzed for important parameters using external analysis. The results of the analysis serve to assess the cultivation process and provide important information about the process. Especially with cultivations carried out in parallel, the manual effort of sample preparation is great and can lead to errors. In order to avoid the need for sampling and thus to minimize the errors, a method is described in the present patent application which makes desired target parameters accessible in the form of soft sensors by means of previously recorded process variables. Herein is described a method for determining process-relevant parameters in CHO processes (Chinese hamster ovary) in high-throughput cultivations, in particular glucose, lactate and the live cell density or the live cell volume.

9.WO/2022/200631BACTERIAL CELLULOSE SUSPENSIONS
WO 29.09.2022
Int.Class C12P 19/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Appl.No PCT/EP2022/058128 Applicant CELLUGY APS Inventor ALVAREZ-MARTOS, Isabel
The invention presented herein relates to bacterial cellulose (BC) suspensions, and methods of production and uses of the same. In particular, the invention relates to BC suspensions suitable for coating applications.
10.WO/2022/202611METHOD FOR PRODUCING USEFUL SUBSTANCE
WO 29.09.2022
Int.Class C12P 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
1Preparation of compounds or compositions, not provided for in groups C12P3/-C12P39/121; General processes for the preparation of compounds or compositions by using microorganisms or enzymes
Appl.No PCT/JP2022/012299 Applicant KANEKA CORPORATION Inventor KISHI, Kenta
A purpose of the present invention is to provide a method for efficiently producing a useful substance while suppressing an increase in turbidity of a liquid sample. The method for producing a useful substance according to the present invention is characterized by including: a step for obtaining a liquid sample including the useful substance using cells; a step for treating the liquid sample by a water-insoluble inorganic compound including one or more elements selected from magnesium, calcium, and aluminum to obtain an adsorption-treated liquid sample; a step for removing the water-insoluble inorganic compound from the adsorption-treated liquid sample; and a step for lowering the pH of the adsorption-treated liquid sample from which the water-insoluble inorganic compound has been removed to 6 or less, then raising the pH 0.1 or more.