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Analysis

1.20220304313METHODS FOR DEGRADING AHL SIGNALING MOLECULES OR PREVENTING PLANT DISEASE CAUSED THEREBY
US 29.09.2022
Int.Class A01N 63/27
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
20Bacteria; Substances produced thereby or obtained therefrom
27Pseudomonas
Appl.No 17701204 Applicant South China Agricultural University Inventor Lianhui ZHANG

The present disclosure belongs to the technical field of biological control and prevention, and it was found that Pseudomonasnitroreducens strain HS-18 has good degradation activity on AHLs with C4-C14 chain length, with an efficient and notable degradation effect, providing a new biocontrol agent for prevention and treatment of AHLs-mediated pathogens provides and broadening the quorum quenching species of AHL signaling molecules. By using molecular biology technologies, AHL-quenching genes for HS-18, i.e., the encoding genes aigA and aigC of N-acyl homoserine lactone acyl transferase are cloned. The genes aigA and aigC have broad-spectrum and efficient quenching activities on AHLs with different side chain lengths and different side chain substituents. The expression of aigA and aicC can significantly weaken the motility of AHL-mediated pathogens, the formation of biofilm and the production of virulence factors and significantly weaken the pathogenicity of pathogens to the host plant.

2.WO/2022/198278BUOYANT BEADS WITH CARBONIC ANHYDRASE FOR ALGAE PRODUCTION
WO 29.09.2022
Int.Class C08J 3/075
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
3Processes of treating or compounding macromolecular substances
02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
03in aqueous media
075Macromolecular gels
Appl.No PCT/AU2022/050271 Applicant THE UNIVERSITY OF MELBOURNE Inventor XU, Xiaoyin
The present invention provides a hydrogel buoyant bead comprising cross-linked carbonic anhydrase, wherein the (hydrated) bead has a density of less than 1.03 g/cm3 (at 20°C). In one embodiment, the bead is a glutaraldehyde crosslinked alginate hydrogel comprising carbonic anhydrase and paraffin oil. The beads may be used in a wide variety of applications but are particularly useful in increasing the uptake of CO2 into an aqueous medium. This application finds particular use in biomass production where a limiting factor in the ability of the biomass to grow is the limited carbonate concentration in the aqueous medium.
3.WO/2022/199553HOMOLOGOUS RECOMBINATION MECHANISM-MEDIATED SEQUENCE REPLACEMENT GENE EDITING METHOD, AND ELEMENT STRUCTURE THEREOF
WO 29.09.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/CN2022/082125 Applicant ANHUI AGRICULTRURAL UNIVERSITY Inventor XU, Yonghan
Provided are a homologous recombination mechanism-mediated precise sequence replacement gene editing method, and an element structure. The method comprises: (1) on the basis of the 300-400 bp DNA sequence of a target region, inserting or deleting a plurality of DNA fragments to form an MsDFID sequence, wherein the MsDFID sequence is simultaneously taken as a guide RNA and donor template, and is also known as an MsDFID guide and donor RNA; (2) linking clustered regularly interspaced short palindromic repeats, namely PCRISR, or a Cas9 guide RNA skeleton, or an Escherichia coli CRISPR-Cas3 palindromic repeat sequence to the 3' end of an MsDFID donor template, and the latter three sequences are all used as guide RNA skeletons; and (3) constructing a donor vector by means of using the above-mentioned fusion sequence, and transforming same into Escherichia coli, wherein the inserted or deleted DNA fragments contained in the donor site in the MsDFID donor template are replaced to a corresponding site of the target region.
4.WO/2022/200858TARGETING ONCOGENTIC MUTATIONS WITH DUAL-CLEAVING ENDONUCLEASE
WO 29.09.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/IB2022/000155 Applicant SPECIFIC BIOLOGICS INC. Inventor STEAD, Brent, E.
Provided herein are compositions and methods of using chimeric nucleases comprising an I-TevI nuclease domain and a Cas domain for the targeting of oncogenes.
5.WO/2022/200633MICRORNA-27B INHIBITORS
WO 29.09.2022
Int.Class A61K 31/712
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
Appl.No PCT/EP2022/058142 Applicant NEUMIRNA THERAPEUTICS APS Inventor KAUPPINEN, Markus Sakari
The present invention provides antisense oligonucleotides complementary to miR-27b, capable of potently inhibiting the activity of miR-27b. Such compounds are useful as pharmaceuticals for treatment of diseases in the CNS or in the PNS including neurological diseases.
6.WO/2022/202043CELL CULTURE CONTAINER AND CELL CULTURE METHOD
WO 29.09.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/JP2022/007072 Applicant TOYODA GOSEI CO., LTD. Inventor TAKI Seitaro
A cell culture container provided with a first container, a second container, and a culture membrane retained between the first container and the second container, in which each of the first container and the second container is provided with a first surface having a retention unit on which the culture membrane is retained, a second surface which faces the first surface, a first cell and a second cell which are located adjacent to each other in a second direction that is orthogonal to a first direction that extends from the first surface toward the second surface, a partitioning wall which partitions between the first cell and the second cell and extends from the first surface toward the second surface, a communication unit which is formed between the partitioning wall and the second surface and allows the first cell and the second cell to be communicated with each other, and a third surface which faces the partitioning wall in the second direction and zones the second cell in conjunction with the second surface, and in which an insertion port is formed.
7.WO/2022/202373METHOD FOR MANUFACTURING PLANT-MILK FERMENTED LIQUID
WO 29.09.2022
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
Appl.No PCT/JP2022/010662 Applicant ASAHI GROUP HOLDINGS, LTD. Inventor SUGAHARA, Hirosuke
Provided is a method for manufacturing a plant-milk fermented liquid having reduced benzaldehyde. This method for manufacturing a plant-milk fermented liquid includes bringing plant milk into contact with a lactic acid bacterium including at least one type of bacterium selected from the group consisting of Lactobacillus fermentum, Lactobacillus reuteri, Lactobacillus oris, and Lactobacillus mucosae.
8.WO/2022/204443EFFICIENT TCR GENE EDITING IN T LYMPHOCYTES
WO 29.09.2022
Int.Class C07K 14/725
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
Appl.No PCT/US2022/021820 Applicant GENENTECH, INC. Inventor RUTZ, Sascha
The present disclosure relates to engineered T cells and methods of making and using the same, as well as reagents for making the engineered T cells.
9.WO/2022/204023COMPOSITIONS AND METHODS FOR RAPID COVID-19 DETECTION
WO 29.09.2022
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/US2022/021138 Applicant DUKE UNIVERSITY Inventor SONG, Xin
The present disclosure provides compositions and methods related to the detection of pathogenic organisms. In particular, the present disclosure provides compositions and methods related to the detection and/or quantification of viral RNA in a sample from a subject that has, or is suspected of having, a SARS-CoV-2 infection. Using rapid reverse-transcription loop-mediated isothermal amplification (RT-LAMP), the compositions and methods of the present disclosure provide a portable, inexpensive, rapid, and accurate assay platform for detecting and/or quantifying the presence of a pathogenic organism (e.g., SARS-CoV-2) in a patient sample.
10.WO/2022/202853EFFICACIOUS ANTI-CD26 ANTIBODY BIOMARKER
WO 29.09.2022
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/JP2022/013309 Applicant Y'S AC CO., LTD. Inventor MORIMOTO, Chikao
In the present invention, a potential prognostic biomarker for CD26-targeted therapy was identified based on phase I trial data of the humanized anti-CD26 monoclonal antibody YS110 for CD26-expressing tumors. Box-and-whisper plot analysis, scatter plot analysis, Pearson's product-moment correlation/Spearman's rank-order correlation, bar graph analysis and receiver operating characteristics (ROC) were used to examine the correlation between soluble CD26 titer variation with YS110 administration and tumor volume change, RECIST criteria evaluation and progression free survival (PFS). The mechanism for serum soluble CD26 titer variation was confirmed by in vitro experimentation. As a result, it was discovered, for the first time, that serum soluble CR26/DPP4 titer variation in the early stage of YS110 treatment is a predictive biomarker for evaluating thereapeutic effect.