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1.20220306735COMPOSITIONS INCLUDING IGG FC MUTATIONS AND USES THEREOF
US 29.09.2022
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No 17638139 Applicant University of Kansas Inventor Brandon DEKOSKY

The present disclosure relates generally to antibodies and Fc fusion proteins comprising Fc variants, and uses thereof. The Fc variants disclosed herein exhibit elevated affinity towards FcRn at pH 6.0, and/or rapidly disassociate from FcRn at pH 7.4 compared to a parent Fc domain

2.WO/2022/200291HUMAN NEUTRALIZING ANTIGEN SPECIFIC PROTEINS FOR SPIKE-RBD OF SARS-COV-2
WO 29.09.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/EP2022/057382 Applicant CEINGE BIOTECNOLOGIE AVANZATE SCARL Inventor DE LORENZO, Claudia
The invention concerns antigen specific proteins, in particular antibodies or fragments thereof, specifically binding to RBD domain and interfering in the interaction of Spike protein with ACE2 receptor, said antigen specific proteins having neutralizing activity for infection of SARS-CoV2 virus and its derived variants.
3.WO/2022/204202ANTIBODIES THAT BIND TO MULTIPLE SARBECOVIRUSES
WO 29.09.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/US2022/021415 Applicant VIR BIOTECHNOLOGY, INC. Inventor CORTI, Davide
The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to S proteins of sarbecoviruses (including, in some embodiments, multiple sarbecoviruses) and, in certain embodiments, are capable of neutralizing infection by multiple sarbecoviruses.
4.WO/2022/198314ANTIBODIES BINDING TO O-LINKED CARBOHYDRATES ON SARS-COV-2 SPIKE PROTEIN AND USES THEREOF
WO 29.09.2022
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/CA2022/050426 Applicant KORANEX CAPITAL Inventor MOFFETT, Serge
A protein complex comprising a SARS-CoV-2 S protein or fragment thereof, expressing one or more carbohydrate antigens, bound to a recombinant ligand having binding specificity for said carbohydrate antigen, is described herein. The carbohydrate antigen may be an O-linked carbohydrate antigen, such as unsialylated Thomsen-Friedenreich (TF) antigen, sialylated TF antigen, unsialylated Tn antigen, sialylated Tn antigen, or any combination thereof. The ligand may be a recombinant antibody or an antigen-binding fragment thereof. Also described herein is the use of such a recombinant ligand for binding to a SARS-CoV-2 S protein or fragment thereof, for treating or reducing the risk of SARS-CoV-2 viral infection in a subject.
5.WO/2022/197882HUMAN IMMUNODEFICIENCY VIRUS (HIV) ANTIGENS AND EPITOPES AND PROTEINS THAT BIND THERETO
WO 22.09.2022
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Appl.No PCT/US2022/020682 Applicant COTROPIA, Joseph Inventor COTROPIA, Joseph
Provided are highly conserved antigens and epitopes of HIV that can be used in vaccines and to produce bindings proteins (e.g., antibodies) for detecting, treating, preventing, or reducing the risk of HIV infection and the development of AIDS.
6.20220298211PLANT-PRODUCED mABs AGAINST CHIKUNGUNYA VIRUS WITH ENHANCED EFFECTOR FUNCTION AND EFFICACY
US 22.09.2022
Int.Class C07K 14/415
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
415from plants
Appl.No 17615803 Applicant Qiang Chen Inventor Qiang Chen

Disclosed are monoclonal antibodies against Chikungunya virus having enhanced effector function and efficacy, methods of producing them, and methods of treatment of Chikungunya viral infection using the antibodies.

7.WO/2022/193980ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF FOR NOVEL CORONAVIRUS NUCLEOCAPSID PROTEIN, AND APPLICATION THEREOF
WO 22.09.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/CN2022/079557 Applicant AMPSOURCE BIOPHARMA SHANGHAI INC. Inventor LI, Qiang
The present invention provides an antibody or an antigen-binding fragment thereof for novel coronavirus nucleocapsid protein, and an application thereof. The antibody is selected from any one of mAb6 antibody, mAb7 antibody, mAb8 antibody and mAb9 antibody; and the antibody is secreted by hybridoma cells having the accession numbers of CCTCC NO: C2020236, CCTCC NO: C2020237, CCTCC NO: C2020238 or CCTCC NO: C2020239. The presence of a novel coronavirus or an antigen thereof in an environmental sample and/or a biological sample can be detected by using the antibody. In addition, the present invention also provides a novel coronavirus detection kit prepared by using the antibody, capable of detecting the nucleocapsid protein in the early stage of infection, thereby providing a means to make the clinical detection of a novel coronavirus fast and precise.
8.WO/2022/196699FOLLICULAR HELPER T (TFH) CELLS SPECIFIC TO SARS-COV-2 VIRUS
WO 22.09.2022
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/JP2022/011707 Applicant OSAKA UNIVERSITY Inventor YAMASAKI, Sho
Provided are follicular helper T cells specific to SARS-CoV-2 virus. On the basis of the discovery of a public Tfh TCR that is specific to a spike (S) protein common to various patients, the present disclosure identifies for the first time a SARS-CoV-2 virus-specific public TCR and the MHC and antigenic epitope thereof and thus promotes efficient immune responses, especially the response of B cells producing a neutralizing antibody. The present disclosure provides, for example, a SARS-CoV-2 virus-specific epitope-containing composition for inducing follicular T cells.
9.WO/2022/197840ADENOVIRUS SARS-COV-2 VACCINE
WO 22.09.2022
Int.Class A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Appl.No PCT/US2022/020604 Applicant THE WISTAR INSTITUTE Inventor ERTL, Hildegund, C., J.
The present invention includes methods and compositions useful for treating or preventing a coronavirus infection in a subject. In certain embodiments the treatment comprises adenoviral-based vaccines against SARS-CoV-2 viral proteins.
10.20220298230ANTIBODIES AND METHODS FOR TREATMENT OF VIRAL INFECTIONS
US 22.09.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No 17617901 Applicant The Rockefeller University Inventor Jeffrey V. Ravetch

The present invention provides antibodies that are capable of activating dendritic cell maturation and/or inducing a protective CDS response. The disclosed antibodies can be used to treat or inhibit viral infections, including prophylaxis and treatment of influenza A infection. The invention also provides nucleic acids that encode and immortalized B cells and cultured plasma cells that produce such antibodies.