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IC:C07D

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Analysis

1.WO/2022/206422COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT CONTAINING SAME, ORGANIC ELECTROLUMINESCENT APPARATUS, AND ELECTRONIC DEVICE
WO 06.10.2022
Int.Class C07D 209/88
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56Ring systems containing three or more rings
80- or -condensed
82Carbazoles; Hydrogenated carbazoles
88with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Appl.No PCT/CN2022/081586 Applicant BEIJING BAYI SPACE LCD TECHNOLOGY CO., LTD. Inventor CAO, Jianhua
The present invention relates to a compound represented by formula (I). The compound is suitable for use in electronic components, in particular, suitable for use in organic electroluminescent elements. The present invention also relates to an electronic component containing said compound.
2.WO/2022/2065125-BENZYLIMIDAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
WO 06.10.2022
Int.Class C07D 233/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Appl.No PCT/CN2022/082526 Applicant WEST CHINA HOSPITAL, SICHUAN UNIVERSITY Inventor YANG, Jun
Provided are a 5-benzylimidazole compound represented by formula I and a preparation method therefor and a use thereof. The compound of formula I and a pharmaceutically acceptable salt thereof can be decomposed in plasma to release the 5-benzylimidazole compound having a pharmacological effect, thereby exerting anesthetic and/or sedative-hypnotic effects in vivo. The compound of formula I has the characteristics of rapid onset, high potency, good circulation stability, and good safety, rapid injection does not cause severe blood pressure fluctuations, good anesthetic and/or sedative-hypnotic effects can also be achieved by oral administration, and the present invention has wide application prospects.
3.WO/2022/206737TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE
WO 06.10.2022
Int.Class C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Appl.No PCT/CN2022/083597 Applicant JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. Inventor YANG, Fanglong
The present disclosure relates to a tetrahydronaphthalene compound, and a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a tetrahydronaphthalene compound as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof as a therapeutic agent, in particular the use thereof as an estrogen receptor degrader, the use in the preparation of a drug for treating and/or preventing estrogen receptor-mediated or dependent diseases or conditions and the use in the preparation of a drug for treating and/or preventing diseases or conditions by means of degrading a target protein.
4.WO/2022/206797EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF
WO 06.10.2022
Int.Class C07D 239/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
48Two nitrogen atoms
Appl.No PCT/CN2022/083919 Applicant BETTA PHARMACEUTICALS CO., LTD Inventor QIU, Changyong
Compounds of formula A, a method for using said compounds as an EGFR inhibitor, and a pharmaceutical composition comprising said compounds. The compounds can be used to treat, prevent or ameliorate diseases or conditions such as cancers or infections.
5.WO/2022/204907METHOD FOR PREPARING COCRYSTAL OF L-PYROGLUTAMIC ACID AND GLUCOPYRANOSYL DERIVATIVE
WO 06.10.2022
Int.Class C07D 207/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
273with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
277Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
282-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Appl.No PCT/CN2021/083791 Applicant SUNSHINE LAKE PHARMA CO., LTD. Inventor GU, Zheng
Provided is a method for preparing a cocrystal of L-pyroglutamic acid and a glucopyranosyl derivative, which can be used as a sodium-dependent glucose transporter (SGLT) inhibitor. The method is stable and controllable, so the target cocrystal can be obtained stably in high-yield and applied to scale-up process.
6.WO/2022/204802USE OF PSYCHEDELICS TO TREAT DEMENTIA
WO 06.10.2022
Int.Class A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Appl.No PCT/CA2022/050468 Applicant MYND LIFE SCIENCES INC. Inventor JEFFERIES, Wilfred
The present invention provides use of psychedelics to prevent and/or treat dementia. In certain embodiments, the one or more psychedelics inhibit neuroinflammation, inhibit cerebral angiogenesis, promote neuroplasticity, down regulate APP and/or Tau or a combination thereof and thereby treat, delay and/or prevent dementia.
7.WO/2022/212077PREPARATION OF SUBSTITUTED DIAMINOPYRAZINE DICARBOXYLIC ACIDS
WO 06.10.2022
Int.Class A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
Appl.No PCT/US2022/020754 Applicant MEDIBEACON INC. Inventor ROGERS, Thomas
The present invention provides improved methods for preparing a compound comprising Formula (I).
8.WO/2022/212647PROTEIN-WIDE MODIFICATION OF ASPARTATES AND GLUTAMATES
WO 06.10.2022
Int.Class C07K 1/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
13Labelling of peptides
Appl.No PCT/US2022/022747 Applicant QUANTUM-SI INCORPORATED Inventor AD, Omer
The present disclosure is related to peptides comprising modified aspartic acid and glutamic acid moieties, methods of making such peptides, and methods of using such modified peptides to selectively direct cleavage of peptide bonds. Selective peptide bond cleavage is advantageous in peptide sequencing applications, such as automated peptide sequencing applications.
9.WO/2022/212707SARS-3CL PROTEASE INHIBITORS
WO 06.10.2022
Int.Class C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Appl.No PCT/US2022/022826 Applicant PRIMMUNE THERAPEUTICS, INC. Inventor WEBBER, Stephen E.
The present invention relates to antiviral agents according to Formula (I) and their use in the treatment of viral infection.
10.WO/2022/212902MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY
WO 06.10.2022
Int.Class A61K 31/165
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
Appl.No PCT/US2022/023146 Applicant ALTOS LABS, INC. Inventor URETA DÍAZ, Gonzalo Andrés
The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.