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1.20220306975ELECTROLYTE-CONTAINING ALCOHOLIC BEVERAGES
US 29.09.2022
Int.Class C12G 3/05
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
GWINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H106
3Preparation of other alcoholic beverages
04by mixing, e.g. for preparation of liqueurs
05with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides
Appl.No 17707008 Applicant JHO INTELLECTUAL PROPERTY HOLDINGS, LLC Inventor John H Owoc

A hard seltzer is made by dissolving a sodium ion source in an aqueous ethanol solution, wherein the aqueous ethanol solution comprises from 1% to 14% by volume of ethanol; dissolving a potassium ion source in the aqueous ethanol solution; dissolving a magnesium ion source in the aqueous ethanol solution; and carbonating the aqueous ethanol solution to produce the hard seltzer. The sodium ion source, the potassium ion source, and the magnesium ion source are used in amounts effective to provide a hard seltzer comprising 20 to 400 mg/serving of sodium ions, 20 to 400 mg/serving of potassium ions; and 3 to 400 mg/serving of magnesium ions.

2.WO/2022/202403ORAL NEISSERIA-MUCOSA-INCREASING AGENT
WO 29.09.2022
Int.Class A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
Appl.No PCT/JP2022/010902 Applicant KAO CORPORATION Inventor FUJII, Akihiko
Provided is a material that is useful for increasing the Neisseria mucosa content in the oral cavity. This oral Neisseria-mucosa-increasing agent has, as active ingredients, a nitrate-ion-supplying compound and one or more sugar alcohols selected from erythritol, xylitol, and mannitol.
3.WO/2022/204068ORAL DELIVERY OF SILICA/ALUMINOSILICATE NANOPARTICLES
WO 29.09.2022
Int.Class A61K 33/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
Appl.No PCT/US2022/021220 Applicant CORNELL UNIVERSITY Inventor GARDINIER, II, Thomas C.
Compositions for oral delivery of silica nanoparticles and/ or aluminosilicate nanoparticles, and methods of use thereof. The individual nanoparticles comprise a silica core or an aluminosilicate core and, optionally, polyethylene glycol (PEG) groups each disposed on a surface of the nanoparticle. In various examples, the nanoparticles have a size of about 20 nm or less. In various examples, the nanoparticles can be delivered to an individual's gastrointestinal tract, pass through the mucus layer thereof, and permeate the epithelial lining thereof. In various examples, the nanoparticles comprise various targeting, diagnostic, or therapeutic group(s) and can retain one or more said activit(ies) after delivery. Methods of oral delivery and methods of treating a disease can comprise orally administering composition(s) to an individual. Non-limiting examples of diseases include infections, cancers, neurological conditions/diseases, neurodegenerative diseases, psychological conditions/diseases, inflammatory conditions/diseases, cardio-vascular diseases, and the like.
4.WO/2022/198438LIGAND-BOUND ZINC SULFIDE NANOPARTICLES, METHODS FOR MAKING THE SAME, AND THEIR USE FOR TREATMENT
WO 29.09.2022
Int.Class A61K 33/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
30Zinc; Compounds thereof
Appl.No PCT/CN2021/082357 Applicant WUHAN VAST CONDUCT SCIENCE FOUNDATION CO., LTD. Inventor SUN, Taolei
Disclosed are ligand-bound zinc sulfide nanoparticles, the method of preparing the ligand-bound zinc sulfide nanoparticles, composition containing ligand-bound zinc sulfide nanoparticles, uses of ligand-bound zinc sulfide nanoparticles and composition containing ligand-bound zinc sulfide nanoparticles, including inhibiting the fibrosis of amyloid-β (Aβ) and reducing the expression of inflammatory factors, treatment of Aβ fibrosis-caused/related Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal ganglion cell degeneration in glaucoma (RGCD) or myositis/myopathy (MM). Preparing drugs for the treatment of AD, CAA, RGCD OR MM and methods for treating the above diseases are also disclosed.
5.WO/2022/203538BIOLOGICALLY ACTIVE QUADROCOMPLEX FOR REGULATING THE BIODIVERSITY OF SKIN MICROBIOTA
WO 29.09.2022
Int.Class A61K 8/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
Appl.No PCT/RU2021/000272 Applicant SKYLAB AG Inventor BELOUS, Elena Yur'evna
The present invention can be used in the manufacture of cosmetic skin care agents for the hands and/or body, as well as household cleaning agents. The claimed biologically active complex is intended for use in cosmetic agents and/or household cleaning agents and consists of: a) essential oil of tea tree (Melaleuca alternifolia), b) alpha-bisabolol, c) 1,8-cineole obtained from leaves of eucalyptus Eucalyptus spp., d) an aqueous solution of citric acid and silver citrate, where said aqueous solution contains 19-23 wt% citric acid and 2280-2640 parts per million of silver citrate, and where the mass ratio of the ingredients a:b:c:d is (0.1-0.5):(0.05-0.3):(0.05-0.35):(0.01-0.2). The quadrocomplex can be used for regulating skin microbiota by, inter alia, inhibiting the growth of a population of opportunistic pathogens, including bacteria and fungi, maintaining the stability of resident microflora, exerting a pronounced antibacterial effect on transient microflora, and breaking down biofilms of opportunistic pathogens.
6.20220305031METHODS FOR REDUCING TUMOR PROGRESSION AND FIBROSIS AND INCREASING ADAPTIVE IMMUNITY IN MALIGNANCIES
US 29.09.2022
Int.Class A61K 31/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Appl.No 17618302 Applicant GEORGETOWN UNIVERSITY Inventor Robert I. GLAZER

Aspects of the technology described herein relate to a method of treating a malignancy in a subject. This method involves selecting a subject having a malignancy and administering dimethyl-3-beta-hydroxy-cholenamide (DMHCA) or derivative thereof to the subject in an amount effective to treat the malignancy. Methods of reducing malignancy-associated fibrosis in a subject and pharmaceutical combinations comprising (i) DMHCA or derivative thereof and (ii) one or more immune checkpoint inhibitors are also disclosed.

7.20220305149NOVEL THERANOSTIC AGENTS FOR PSMA POSITIVE CANCERS
US 29.09.2022
Int.Class A61K 51/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
08Peptides, e.g. proteins
10Antibodies or immunoglobulins; Fragments thereof
Appl.No 17638512 Applicant Memorial Sloan Kettering Cancer Center Inventor Naga Vara Kishore PILLARSETTY

The present disclosure provides compositions and methods for the detection and treatment of cancer. Specifically, the compositions of the present technology include novel radiohalogenated (e.g., radioiodinated) PSMA targeting agents and methods of using the same in diagnostic imaging as well as radiation therapy.

8.20220305053SKIN CONTACT TYPE MEDICAL SEMICONDUCTOR USING DIVALENT METAL OXIDE FILM FOR MUSCULOSKELETAL PAIN RELIEF AND METHOD OF DELIVERING IONS USING THE SAME
US 29.09.2022
Int.Class A61K 33/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
06Aluminium, calcium or magnesium; Compounds thereof
08Oxides; Hydroxides
Appl.No 17388790 Applicant Semiconductor Lobac Co., Ltd. Inventor SOOYUN OH

A medical semiconductor is used to improve musculoskeletal pain by bringing a divalent metal (magnesium alloy) oxide film semiconductor into contact with the skin.

9.WO/2022/201200BROAD-SPECTRUM ANTIMICROBIAL FORMULATIONS PREPARED FROM ELECTROLYTICALLY GENERATED METAL IONS AND METHODS OF PREPARATION
WO 29.09.2022
Int.Class A61K 33/242
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
242Gold; Compounds thereof
Appl.No PCT/IN2022/050295 Applicant GORADIA, Prerna Inventor GORADIA, Prerna
The present invention relates to light insensitive and thermally stable antimicrobial formulations of electrolytically generated transition metal ions. The specific combination of metal ions gives it a broad spectrum anti-microbial ability against potentially pathogenic bacteria, virus, fungi, mold, mildew and antibiotic resistant species. The low viscosity formulations of the present invention are easy to be dosed, stand alone preservatives, providing a big change in the cosmetics and food industry. These eco-friendly formulations are effective alternatives to formaldehyde donors and parabens, with high bioavailability in water and oily phases. The alcohol and surfactants free formulations are effective in very small doses. Since, no organometallics or salts are used as the metal source in the present invention, this makes the formulations safe for sensitive applications such as in the cosmetics and food industry.
10.WO/2022/203090COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER
WO 29.09.2022
Int.Class A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
Appl.No PCT/JP2022/017017 Applicant ASTELLAS PHARMA INC. Inventor BHATTACHARYA, Pranob P.
The present invention provides a combination therapy for treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.