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Analysis

1.WO/2022/007326METHOD AND USE FOR REAL-TIME FLUORESCENT PCR DETECTION OF CRONOBACTER SAKAZAKII O-ANTIGEN
WO 13.01.2022
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/CN2020/135549 Applicant NANKAI UNIVERSITY Inventor GUO, Xi
A method and use for real-time fluorescent PCR detection of Cronobacter sakazakii O-antigen, primarily utilizing a real-time fluorescent PCR reaction rapid detection system of an MGB probe to detect seven O-antigen serotypes of Cronobacter sakazakii. With Cronobacter sakazakii O1-O2-type and O4-O6-type wzy genes and O3-type and O7-type wzx genes as target genes, a Taqman specific primer and the MGB probe directed at each serotype are designed and screened, and a real-time fluorescent PCR detection method is established. The detection method accurately, rapidly, and sensitively performs molecular biology detection of all seven Cronobacter sakazakii O-antigen serotype strains.
2.WO/2022/008826METHOD FOR DETERMINING THE RISK OF COMPLICATION IN A PATIENT
WO 13.01.2022
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/FR2021/051228 Applicant BIOMÉRIEUX Inventor VACHOT, Laurence
The invention relates to an in vitro or ex vivo method for determining the risk of incidence of a care-related infection in a patient, including a step of measuring the expression of C3AR1 in a biological sample from said patient.
3.WO/2022/009051A METHOD FOR DETERMINING RESPONSIVENESS TO PROSTATE CANCER TREATMENT
WO 13.01.2022
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/IB2021/055968 Applicant JANSSEN BIOTECH, INC. Inventor SMIRNOV, Denis A.
Disclosed herein are methods of diagnosing and treating a subject with prostate cancer, as well as methods of monitoring the responsiveness of a subject having prostate cancer to a therapeutic agent.
4.WO/2022/010206QUARANTINE SYSTEM FOR HIGH-RISK INFECTIOUS DISEASE USING ISOTHERMAL AMPLIFICATION-BASED MOLECULAR DIAGNOSTICS
WO 13.01.2022
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/KR2021/008506 Applicant SEASUN BIOMATERIALS Inventor PARK, Sungmin
The present invention relates to a COVID-19 quarantine system using isothermal amplification-based molecular diagnostics for detecting SARS-CoV-2, and in particular, to a quarantine system in an airport, a port, a massive rally, or a superspreader area. According to the present invention, it is possible to quickly and accurately test COVID-19 infection on a large scale, and thus the present invention is effective for the quarantining of mass service facilities, such as airports, ports, and gymnasiums.
5.WO/2022/010386USE OF COFACTOR FO AND ANALOGUES THEREOF AS A BIOLUMINESCENCE REACTION COMPONENT
WO 13.01.2022
Int.Class C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/RU2021/050207 Applicant YAMPOL'SKIY, Il'ya Viktorovich Inventor YAMPOL'SKIY, Il'ya Viktorovich
Components of bioluminescent systems are widely used reagents for a large number of assays, including diagnostic systems, quality control systems, drug trial systems and the like. The present group of inventions discloses components of the bioluminescent system of Henlea petushkovi and Henlea rodionovae (Henlea sp.) worms, in particular bioluminescence cofactor (activator) molecules. The present group of inventions further discloses a method for identifying luciferase in biological samples using bioluminescence cofactor (activator) molecules from Henlea petushkovi and Henlea rodionovae (Henlea sp.) worms, and a method for detecting bioluminescence in a biological sample.
6.WO/2022/010866TUMOR MICROENVIRONMENT-BASED METHODS FOR ASSESSING CAR-T AND OTHER IMMUNOTHERAPIES
WO 13.01.2022
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/US2021/040469 Applicant BOSTONGENE CORPORATION Inventor KOTLOV, Nikita
Aspects of the disclosure relate to methods for determining whether or a subject is likely to respond to certain adoptive cell therapies (e.g., chimeric antigen receptor (CAR) T-cell therapy, etc.). In some embodiments, the methods comprise the steps of identifying a subject as having a tumor microenvironment (TME) type based upon a molecular- functional (ME) expression signature of the subject, and determining whether or not the subject is likely to respond to a chimeric antigen receptor (CAR) T-cell therapy based upon the TME type. In some embodiments, the methods comprise determining the lymphoma microenvironment (LME) type of a lymphoma (e.g., Diffuse Large B cell lymphoma (DLBCL)) subject and identifying the subject's prognosis based upon the LME type determination.
7.20220010361TARGET ENRICHMENT USING NUCLEIC ACID PROBES FOR scRNAseq
US 13.01.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No 17373519 Applicant Becton, Dickinson and Company Inventor Hye-Won Song

Disclosed herein include systems, methods, compositions, and kits for performing targeted single cell mRNA sequencing assays. Capture oligonucleotides capable of specifically binding to target nucleic acid species are provided in some embodiments. Depletion oligonucleotides capable of specifically binding to undesirable nucleic acid species are provided in some embodiments. The method can comprise random priming and extension of barcoded transcripts followed by one or more enrichment and/or depletion steps using said capture oligonucleotides and/or depletion oligonucleotides. Immune repertoire profiling methods are also provided in some embodiments.

8.WO/2022/006667DIAGNOSIS AND TREATMENT OF CHRONIC DIABETIC COMPLICATIONS USING LONG NON-CODING RNAS AS TARGETS
WO 13.01.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/CA2021/050924 Applicant THE UNIVERSITY OF WESTERN ONTARIO Inventor CHAKRABARTI, Subrata
Method of identifying a subject as having an increased likelihood of progressing to end-organ damage due to diabetes comprising comparing the amount of a lncRNA in a sample from the subject with a reference value, and if the amount of the lncRNA in the sample is increased relative to the reference value, identifying the subject as having an increased probability of progressing to end-organ damage due to diabetes. The lncRNA is one or more of HOTAIR, H19, WISPER, ZFAS1, HULC, ANRIL, MALAT1, MIAT, and MEG3. Also methods of treating chronic diabetic complications and other conditions comprising administering a HOTAIR inhibitor.
9.WO/2022/007747PHOSPHORUS-EFFICIENT AND HIGH-YIELD GENE OF CROPS, AND APPLICATION THEREOF
WO 13.01.2022
Int.Class C12N 15/84
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
84Ti-plasmids
Appl.No PCT/CN2021/104527 Applicant CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES Inventor HE, Zuhua
Provided are a phosphorus-efficient and high-yield gene of crops, and an application thereof. It is first disclosed that a PHO1;2 gene has a regulating function on filling of crop kernels. Up-regulating the expression of the gene in crops can significantly promote filling of the crop kernels, increase the kernel weight of the crop kernels, the kernels per spike, the tiller number and the kernel thickness, and/or promote thickening of the crops. The PHO1;2 gene plays a two-way phosphorus transport effect which mainly conveys phosphorus to the extracellular domain, can regulate intracellular phosphorus accumulation, increase the utilization rate of phosphorus in crops, and improve the duration of crops to a low-phosphorus environment.
10.WO/2022/007897METHOD FOR ACTIVATING FOLLICLES BY MEANS OF USING SMALL-MOLECULE COMPOUND, AND PREPARATION THEREOF
WO 13.01.2022
Int.Class C07D 303/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
303Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
Appl.No PCT/CN2021/105248 Applicant TSINGTAO A-SMART MEDICAL TECHNOLOGY CO., LTD. Inventor MA, Jinlong
Disclosed are a method and culture medium for performing an in vivo treatment on ovaries of mammals including humans or performing in vitro culturing on ex vivo ovaries or ovarian tissue by means of using 4-vinylcyclohexene diepoxide. The method or culture medium provided facilitates the retention and enhancement of the developmental and reproductive potential of mammalian ovaries or ovarian tissue, and is particularly capable of promoting follicle maturation and increasing the number of ovulations.