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1.20220010348METHOD FOR PRODUCING OLIGONUCLEOTIDE HAVING PHOSPHOROTHIOATED SITE
US 13.01.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 17485785 Applicant AJINOMOTO CO., INC. Inventor Taisuke ICHIMARU

A method including obtaining a phosphite form or a phosphorous acid diester form by coupling a nucleoside, nucleotide or oligonucleotide wherein a 5′-hydroxy group is not protected, and other group is optionally protected by a protecting group used for nucleic acid synthesis or bonded to a solid phase carrier, and a nucleoside, nucleotide or oligonucleotide wherein a 3′-hydroxy group or a 3′-amino group is modified by a method for forming a phosphite form or a phosphorous acid diester form, and other group is optionally protected by a protecting group used for nucleic acid synthesis in the presence of an antioxidant is useful for producing an oligonucleotide having a phosphorothioated site.

2.11220707Compositions and methods for pairwise sequencing
US 11.01.2022
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 17377284 Applicant Element Biosciences, Inc. Inventor Sinan Arslan

The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g., having nucleotide units), the signals emitted by the nucleotides or nucleotide units that participate in the parallel sequencing reactions along the concatemer yields an increased signal intensity for each concatemer.

3.20220001387THERMAL CYCLING METHODS AND APPARATUSES FOR CARRYING OUT EFFICIENT POLYMERASE CHAIN REACTION (PCR) PROCESSES TO AMPLIFY DEOXYRIBONUCLEIC ACID (DNA)
US 06.01.2022
Int.Class B01L 7/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
7Heating or cooling apparatus; Heat insulating devices
Appl.No 17479390 Applicant CBF Systems Inc. Inventor Curtis Barry FIGLEY

A thermal cycling method and associated device is described. The method is for carrying out a polymerase chain reaction (PCR) process to amplify deoxyribonucleic acid (DNA), and the method includes: pre-heating a series of blocks to respective temperatures that correspond to different respective heating stages in a PCR process, in which each block of the series of blocks defines a respective heat transfer surface, in which the series of blocks define a sequence of positions along a path, with each position defined by a respective heat transfer surface of a respective block; and moving a PCR reaction vessel, which contains deoxyribonucleic acid (DNA) and PCR reagents, along the path into and out of each respective position in the sequence of positions according to a schedule, in which, at each respective position the PCR reaction vessel is in thermal contact with the respective heat transfer surface to equilibrate a temperature of the PCR reaction vessel to a target temperature that corresponds to a respective heating stage in the PCR process.

4.WO/2022/006042METHODS, COMPOSITIONS, AND KITS FOR NUCLEIC ACID BARCODING OF BIOMOLECULES
WO 06.01.2022
Int.Class C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Appl.No PCT/US2021/039506 Applicant PRESIDENT AND FELLOWS OF HARVARD COLLEGE Inventor SAKA, Sinem, K.
Provided herein are methods, compositions, and kits related to barcoding target binding molecules for diagnostics, treatments, and research applications. In some aspects, provided herein is a method for biomolecule tagging and barcoding.
5.1020210158794더블 와이드 밴드의 형성을 통한 하이드로겔화 핵산의 생산 시스템 및 이의 용도
KR 31.12.2021
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No 1020210078153 Applicant 프로지니어 주식회사 Inventor 엄숭호
본 발명은 더블 와이드 밴드의 형성을 통한 핵산 하이드로겔의 제조 시스템 및 이의 용도에 관한 것으로, 본 발명의 핵산 하이드로겔 제조 시스템으로 제조된 핵산은 현재 존재하는 세포 내/외 핵산 합성방법, 특히 RNA의 합성에 있어서 고비용 및 저수율의 한계를 극복하고, 하이드로겔화로 인해 RNA를 안정화하여, 기능성 RNA 기반의 기술 분야에서 유용하게 사용될 수 있다. 특히, 본 발명의 핵산 제조 시스템은 기존의 본 발명자들의 G-사중합체 기반의 핵산 합성기술에서, 목적서열이 150bp 이상인 경우 또는 의도치 않은 2차 구조를 형성하는 경우에, 하이드로겔화가 급격히 감소하는 현상을 해결하여 기능성 RNA(목적 RNA)의 크기와 관계없이 전 범위의 핵산 하이드로겔을 저비용 고수율로 합성이 가능하여, RNA의 대량 합성이 요구되는 분야에 유용하게 사용될 수 있다. 나아가, 본 발명의 시스템으로 제조된 핵산 하이드로겔을 사용하여 펩타이드 또는 단백질을 제조하는 경우, 제조 수율을 극대화 할 수 있다는 장점이 있으며, 따라서, 기능성 펩타이드 또는 단백질의 세포 내/외 합성, 기능성 핵산 기반의 기술을 사용하는 생명과학, 의료, 식품 등 다양한 분야에 유용하게 사용될 수 있다.
6.20210403968MICROELECTRODE ARRAY WITH A SWITCHABLE HYDROPHILIC SURFACE
US 30.12.2021
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 16917650 Applicant MICROSOFT TECHNOLOGY LICENSING, LLC Inventor Bichlien NGUYEN

A switchable hydrophilic surface is created by attaching electrochemically switchable hydrophilicity polymers to the surface of a microelectrode array. Ferrocene polymers are one example of electrochemically switchable hydrophilicity polymers. Activation of electrodes in the microelectrode array changes the oxidation state of metal ions which switches the polymers between hydrophobic and hydrophilic conformations. Selective activation of electrodes can create patterns of wettability on the microelectrode array that may be varied in real time. The switchable hydrophilic surface may be used to control solid-phase synthesis of polymers. Growing polymers may be selectively extended at locations on the microelectrode array that are hydrophilic. The pattern of hydrophobic and hydrophilic regions can be changed during sequential rounds of synthesis to create a variety of different polymers at different locations on the surface of the microelectrode array.

7.20210403982MULTIPHASE NUCLEIC ACID AMPLIFICATION
US 30.12.2021
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No 17328312 Applicant GEN-PROBE INCORPORATED Inventor Norman C. NELSON

Improved methods for use in nucleic acid amplification, including multiplex amplification, where the amplification is carried out in two or more distinct phases are disclosed. The first phase amplification reaction preferably lacks one or more components required for exponential amplification. The lacking component is subsequently provided in a second, third or further phase(s) of amplification, resulting in a rapid exponential amplification reaction. The multiphase protocol results in faster and more sensitive detection and lower variability at low analyte concentrations. Compositions for carrying out the claimed methods are also disclosed.

8.WO/2021/259201NUCLEIC ACID LIGAND AND USE THEREOF
WO 30.12.2021
Int.Class C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Appl.No PCT/CN2021/101244 Applicant NUHIGH BIOTECHNOLOGIES CO., LTD. Inventor HE, Wenlong
Provided are a nucleic acid ligand (nucleic acid polymerase substrate analog), a mixture thereof, and the use thereof. The mixture of the nucleic acid polymerase substrate analog contains two or more nucleic acid polymerase substrate analogs. The nucleic acid polymerase substrate analog is a single nucleic acid molecule or nucleic acid molecule analog which forms complementary pairing within a molecule, or a single or two nucleic acid molecules or nucleic acid molecule analogs which form complementary pairing between molecules; and a structure formed thereby has the characteristics of a nucleic acid polymerase substrate. When an amplification reaction mixture is at or below a certain temperature, the enzyme activity of a nucleic acid polymerase is inhibited by means of the nucleic acid ligand and there is no residual enzyme activity. When the reaction mixture is heated, the nucleic acid polymerase is separated from the nucleic acid polymerase substrate analog to exert activity and form a primer extension product, thereby achieving the effect of inhibiting non-specific amplification. The nucleic acid polymerase substrate analog is suitable for all polymerases and can be widely used in the field of nucleic acid amplification. The 3' end of the nucleic acid ligand has a modification which inhibits the extension thereof.
9.113832147一种高效的大片段DNA合成与扩增的PCR引物、方法及应用
CN 24.12.2021
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No 202111051247.2 Applicant 华南农业大学 Inventor 刘耀光
本发明公开了一种高效、特异地合成与扩增大片段DNA的PCR引物、方法及应用。本发明通过特别设计扩增引物,在正向引物和反向引物5'端添加相同的任意短序列,使扩增序列的单链DNA末端形成反向重复序列并配对产生发夹结构,对引物二聚体和短小的非特异DNA片段的扩增有良好的抑制效果;而较大的目标DNA片段末端难以相互配对不产生发夹结构,因而可避免非特异产物的竞争而被高效地特异性扩增。进一步,本发明使用嵌套式交错变温内循环,可优化目标序列的不同GC含量区间的有效延伸,与上述抑制效果的倍加效应最终提高PCR的扩增效率和特异性;本发明可提高大片段DNA序列从头合成的能力,从不同物种的基因组等各种模板扩增大片段目标DNA,扩增的DNA片段可应用于载体克隆、表达和基因组测序等目的,在分子生物学、合成生物学和生物技术领域具有重要的应用价值。
10.WO/2021/257453CHIMERIC AMPLICON ARRAY SEQUENCING
WO 23.12.2021
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2021/037226 Applicant THE BROAD INSTITUTE, INC. Inventor HACOHEN, Nir
The present disclosure relates to compositions and methods for nucleic acid sequencing, and specifically, at least in certain aspects, provides methods and compositions for enhancing the efficacy, throughput and/or yield of known long-range sequencing platforms, by providing chimeric arrays of input sequences. Such arrays of component nucleic acid sequence elements can be prepared via methods that minimize introduction of bias. The application of the current methods to obtain isoform sequencing information, e.g., from patient samples is specifically also provided, as are methods for mitochondrial lineage tracing that employ the instant chimeric amplicon sequencing processes. Methods and systems for array nucleic acid sequence processing and interpretation are also provided.