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1.20220010282THREE-DIMENSIONAL CELL CULTURE, DEVICES, AND USE THEREOF
US 13.01.2022
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
Appl.No 17349646 Applicant THE BROAD INSTITUTE, INC. Inventor Jeffrey Karp

3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic β cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.

2.20220010262Method For Dissociation Of Cells
US 13.01.2022
Int.Class C12N 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
02Separating microorganisms from their culture media
Appl.No 17369390 Applicant Grain Processing Corporation Inventor Sarjit Johal

Disclosed is a method for the dissociation of cells. Cells are processed under varying conditions of pH, temperature, and shear to thereby produce different cell products. In one form, the cells are jet cooked at a lower temperature and/or pressure to provide products that are relatively delicate. The remaining cell components may then be subsequently jet cooked under higher temperature and/or shear conditions to provide products that are relatively more robust. Generally, the cells become dissociated, whereby at least one separate cell wall component is substantially separate from the dissociated cell walls.

3.20220009878IONIZABLE AMINE LIPIDS
US 13.01.2022
Int.Class C07C 229/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
10the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
12to carbon atoms of acyclic carbon skeletons
Appl.No 17282157 Applicant Intellia Therapeutics, Inc. Inventor Rubina Giare Parmar

The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.

4.WO/2022/007326METHOD AND USE FOR REAL-TIME FLUORESCENT PCR DETECTION OF CRONOBACTER SAKAZAKII O-ANTIGEN
WO 13.01.2022
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/CN2020/135549 Applicant NANKAI UNIVERSITY Inventor GUO, Xi
A method and use for real-time fluorescent PCR detection of Cronobacter sakazakii O-antigen, primarily utilizing a real-time fluorescent PCR reaction rapid detection system of an MGB probe to detect seven O-antigen serotypes of Cronobacter sakazakii. With Cronobacter sakazakii O1-O2-type and O4-O6-type wzy genes and O3-type and O7-type wzx genes as target genes, a Taqman specific primer and the MGB probe directed at each serotype are designed and screened, and a real-time fluorescent PCR detection method is established. The detection method accurately, rapidly, and sensitively performs molecular biology detection of all seven Cronobacter sakazakii O-antigen serotype strains.
5.WO/2022/007881MODIFIED GLUTAMATE DEHYDROGENASE AND USE THEREOF
WO 13.01.2022
Int.Class C12N 9/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
06acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
Appl.No PCT/CN2021/105179 Applicant SICHUAN LIER BIOTECHNOLOGY CO., LTD. Inventor XIE, Xinkai
Provided is modified glutamate dehydrogenase (GluDH). In particular, the modified GluDH provided has an improved activity of catalyzing PPO to react with an amino donor to generate L-glufosinate-ammonium and/or has an improved kinetic property. Further provided are a polynucleotide for encoding the modified GluDH, a vector and host cell for expressing the modified GluDH of the present invention, and a method for producing L-glufosinate-ammonium by means of using the modified GluDH and the host cell.
6.WO/2022/008466BASE EDITING TOOLS
WO 13.01.2022
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
Appl.No PCT/EP2021/068559 Applicant WAGENINGEN UNIVERSITEIT Inventor MOUGIAKOS, Ioannis
Thermostable, type II-C Cas9 variants of Geobacillus thermodenitrificans T12 (ThermoCas9) and Geobacillus stearothermophilus (GeoCas9) use 23 nt spacers to edit sites adjacent to an N4CVAA/N4CCCA or N4CRAA PAM, respectively. These Cas9 variants are linked to a cytidine deaminase enzyme from the sea lamprey Petromyzon marinus (PmCDA1) to provide: (a) dThermoTarget-AID, (b) dGeoTarget- AID, (c) AcrThermoTarget-AID, and (d) AcrGeoTarget-AID. Compared to known base editors, these systems exhibit much larger base editing windows: (a) from -5 to -27 positions relative to the PAM (23 bp); (b) from -5 to -24 positions relative to the PAM (20 bp); (c) from -5 to -27 positions relative to the PAM (23 pb); (d) from -3 to - 28 positions relative to the PAM (26 bp). The first two editors employ the catalytically inactive ThermoCas9 or GeoCas9, respectively, while the last two editors co-express a small anti-CRISPR protein from Neisseria meningitidis (AcrIIC1Nme) with active ThermoCas9 or GeoCas9, respectively. Methods of gene editing are described.
7.WO/2022/010386USE OF COFACTOR FO AND ANALOGUES THEREOF AS A BIOLUMINESCENCE REACTION COMPONENT
WO 13.01.2022
Int.Class C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/RU2021/050207 Applicant YAMPOL'SKIY, Il'ya Viktorovich Inventor YAMPOL'SKIY, Il'ya Viktorovich
Components of bioluminescent systems are widely used reagents for a large number of assays, including diagnostic systems, quality control systems, drug trial systems and the like. The present group of inventions discloses components of the bioluminescent system of Henlea petushkovi and Henlea rodionovae (Henlea sp.) worms, in particular bioluminescence cofactor (activator) molecules. The present group of inventions further discloses a method for identifying luciferase in biological samples using bioluminescence cofactor (activator) molecules from Henlea petushkovi and Henlea rodionovae (Henlea sp.) worms, and a method for detecting bioluminescence in a biological sample.
8.WO/2022/010761TDP-43 BIOSENSOR CELL LINES
WO 13.01.2022
Int.Class A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Appl.No PCT/US2021/040238 Applicant THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Inventor DIAMOND, Marc, I.
The present disclosure provides methods for the identification, characterization and ranking of putative tau monomer stabilizing agents. Specifically, the disclosure provides methods for assessing the capability of a test compound to stabilize a tau monomer, methods of prioritizing a plurality of test compounds from a library identified as tau monomer stabilizing agents, methods of screening a test compound library to identify tau monomer stabilizing agents, and a kit providing the reagents to perform the described methods.
9.WO/2022/011151MYBPC3 POLYPEPTIDES AND USES THEREOF
WO 13.01.2022
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No PCT/US2021/040906 Applicant CHILDREN'S MEDICAL CENTER CORPORATION Inventor PU, William, T.
Provided herein are compositions and methods for treating a disorder associated with abnormal RYR2 function (e.g., arrhythmia or heart failure). In some embodiments, method comprises administering to a subject in need thereof an effective amount of a polypeptide comprising a C -terminal domain of Cardiac Myosin binding protein C (MYBPC3) or a nucleic acid or an rAAV encoding such polypeptide.
10.WO/2022/006667DIAGNOSIS AND TREATMENT OF CHRONIC DIABETIC COMPLICATIONS USING LONG NON-CODING RNAS AS TARGETS
WO 13.01.2022
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Appl.No PCT/CA2021/050924 Applicant THE UNIVERSITY OF WESTERN ONTARIO Inventor CHAKRABARTI, Subrata
Method of identifying a subject as having an increased likelihood of progressing to end-organ damage due to diabetes comprising comparing the amount of a lncRNA in a sample from the subject with a reference value, and if the amount of the lncRNA in the sample is increased relative to the reference value, identifying the subject as having an increased probability of progressing to end-organ damage due to diabetes. The lncRNA is one or more of HOTAIR, H19, WISPER, ZFAS1, HULC, ANRIL, MALAT1, MIAT, and MEG3. Also methods of treating chronic diabetic complications and other conditions comprising administering a HOTAIR inhibitor.