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Analysis

1.20220010282THREE-DIMENSIONAL CELL CULTURE, DEVICES, AND USE THEREOF
US 13.01.2022
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
Appl.No 17349646 Applicant THE BROAD INSTITUTE, INC. Inventor Jeffrey Karp

3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic β cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.

2.WO/2022/010982MICROSCALE BIOREACTOR SYSTEM FOR AND METHOD OF PROVIDING CELL CULTURE GROWTH CONDITIONS IN A SMALL-VOLUME VESSEL
WO 13.01.2022
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/US2021/040635 Applicant REDBUD LABS, INC. Inventor GURNEY, Travis
A microscale bioreactor system for and method is disclosed for providing improved cell culture growth conditions in a small-volume vessel. For example, a microbioreactor system is provided that may include a small-volume vessel and wherein the small-volume vessel may include a field of actuatable surface-attached microposts. Further, the microbioreactor system may include an actuation mechanism for actuating the surface-attached microposts into movement. In some embodiments, the surface-attached microposts may be functionalized with, for example, activation signals for converting standard T-cells in a growth media to activated T-cells. Further, a method of using the microbioreactor system for providing cell culture growth conditions including enhanced oxygenation and nutrients distribution in a small-volume vessel is provided.
3.WO/2022/008733MICROFLUIDIC CELL CULTURE DEVICE
WO 13.01.2022
Int.Class C12M 1/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
32multiple field or continuous type
Appl.No PCT/EP2021/069205 Applicant MIMETAS B.V. Inventor TRIETSCH, Sebastiaan Johannes
A microfluidic cell culture device is described. The device comprises a microfluidic network comprising a base, a microfluidic channel, and a cover, and at least one perfusion compartment and at least one support compartment inside the microfluidic channel. The base and cover each comprise an aperture, thereby defining a conduit through the microfluidic channel. The aperture is in fluidic contact with the at least one support compartment, and with the at least one perfusion compartment through the at least one support compartment. Methods for creating a fluid-fluid interface and for investigating a cellular response to a stimulant using the device are also described.
4.WO/2022/010473MEASURING DEFORMABILITY OF A CELL VIA A PRESSURE FIELD
WO 13.01.2022
Int.Class G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
49blood
Appl.No PCT/US2020/041232 Applicant HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. Inventor D'APUZZO, Fausto
An example method for measuring deformability of a cell via a pressure field, consistent with the present disclosure, includes flowing a biologic sample containing a plurality of cells along a first fluidic channel and into an intersection between the first fluidic channel and a second fluidic channel of a microfluidic device. The method includes introducing a pressure field at the intersection and into the first fluidic channel via the second fluidic channel and a plurality of apertures in a channel wall disposed in the intersection. The method further includes measuring deformability of a cell among the plurality of cells responsive to the introduction of the pressure field.
5.WO/2022/011163SUPPORT AND SYSTEM FOR ENGINEERED TISSUE
WO 13.01.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/US2021/040923 Applicant NOVOHEART LIMITED Inventor ROBERTS, Erin, G.
The present disclosure relates to tissue supports for use with engineered tissues and organoids, such as cardiac organoid chambers. In an embodiment of the present disclosure, the tissue supports are provided with a fluid-impermeable resilient member that is resiliently deformable during testing by cultured tissues formed on the surface of the tissue support.
6.WO/2022/010474DEFORMABILITY OF A CELL RESPONSIVE TO A PRESSURE WAVE
WO 13.01.2022
Int.Class G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
49blood
Appl.No PCT/US2020/041235 Applicant HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. Inventor D'APUZZO, Fausto
An example method for measuring deformability of a cell responsive to a pressure wave, consistent with the present disclosure, includes moving a cell of a sample into a cell probing chamber of a microfluidic device. While the cell is in the cell probing chamber, the method includes generating a pressure wave within the cell probing chamber by actuating a fluidic pump. The method further includes determining a deformability of the cell responsive to the pressure wave, using an imaging array synchronized with the actuation of the fluidic pump.
7.WO/2022/010594HERMETICALLY OR ASEPTICALLY SEALED BIOREACTOR SYSTEM AND RELATED METHOD THEREOF
WO 13.01.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/US2021/034940 Applicant UNIVERSITY OF VIRGINIA PATENT FOUNDATION Inventor CHRIST, George
Disclosed herein are details of a hermetically or aseptically sealed bioreactor. The bioreactor comprises a bioreactor chamber, a membrane wall, a scaffold structure, a linear actuator, a linear transfer means, and a control system. Use of the bioreactor permits the inner scaffold structure to be moved and manipulated while still preserving a hermetic or aseptic seal inside the bioreactor chamber during operation.
8.WO/2022/011169FILTRATION ASSEMBLIES, CASSETTES, SYSTEMS, AND METHODS FOR FILTRATION AND CELL GROWTH
WO 13.01.2022
Int.Class C12M 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
Appl.No PCT/US2021/040935 Applicant RAPID MICRO BIOSYSTEMS, INC. Inventor RIPPETH, John
The present invention features filtration assemblies, cassettes, systems, and methods for filtering cells from a sample solution and then incubating the captured cells.
9.20220010350GAS TESTING UNIT AND METHOD
US 13.01.2022
Int.Class C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
Appl.No 17449078 Applicant LanzaTech New Zealand Limited Inventor Bjorn Daniel Heijstra

A fermentation unit and a method of carrying out fermentation are described. The fermentation unit can be transported from one facility to another to carry out a fermentation process. The fermentation unit and method allow for the fermentation of a C1-containing substrate from a source at a particular facility to produce products such as alcohols and acids. Examples of the source of the C1-containing substrate include without limitation steel manufacturing processes, coal and biomass gasification processes, coke manufacturing processes, etc. The fermentation unit can be housed within a container having a volume of less than about 6 m3.

10.WO/2022/008292AN INCUBATOR FOR RECEIVING A NUMBER OF CELL CULTURE CHAMBER DEVICES
WO 13.01.2022
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/EP2021/067777 Applicant CELVIVO APS Inventor JOCHUMSEN, Hans Henrik
This invention relates to an incubator (200, 200') configured to receive a predetermined number, at least one or a plurality, of cell culture chamber devices (100), each cell culture chamber device (100) comprising an enclosure (110) configured to contain a cell culture media, the incubator (200, 200') comprising a housing (210) comprising an incubation chamber (201) configured to contain at least a respective part of the cell culture chamber devices (100) when received by the incubator (200, 200'), and at least one registration and/or detection device (220) being integrated with the incubator (200, 200') and being configured to register and/or detect an illumination or visualisation signal (703) after passing, reflecting, or propagating through at least a part of the enclosure (110) of at least one of the predetermined number of cell culture chamber devices (100) when received by the incubator (200, 200').