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1.20220010282THREE-DIMENSIONAL CELL CULTURE, DEVICES, AND USE THEREOF
US 13.01.2022
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
Appl.No 17349646 Applicant THE BROAD INSTITUTE, INC. Inventor Jeffrey Karp

3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic β cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.

2.102020004136Kulturerhaltender und hydraulisch umwälzbarer Methanfermenter
DE 13.01.2022
Int.Class C12M 1/107
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
107with means for collecting fermentation gases, e.g. methane
Appl.No 102020004136 Applicant Apelt Christine Inventor Auerbach Hans-Joachim

Kulturerhaltende und hydraulisch umwälzbare Methanfermenter werden nach dem Stand der Technik durch das regelmäßige Rückströmen des zuvor mittels Gasdruck von einem Fermenterbereich in einen zweiten Fermenterbereich verdrängten Gärsubstrates betrieben. Durch besondere Weiterentwicklungen der konstruktiven Gestaltung des kulturerhaltenden und hydraulisch umwälzbaren Methanfermenters gelingt es nun, die gegenseitigen Beeinflussungen der aktiven Mikrokulturen in den beiden weiterhin verbundenen Fermenterbereichen infolge des Rückströmens zu vermeiden, so dass die Gasentbindung durch die zunehmend an die jeweilige Gärsubstratbeschaffenheit in den einzelnen Fermenterbereichen adaptierten Mikrokulturen die Gasentbindung in beiden Fermenterbereichen so deutlich verstärkt, dass allein dadurch eine stetige Umwälzung des Gärsubstrates in beiden Fermenterbereichen bewirkt wird und in der Folge auf das die Spezialisierung der aktiven Kulturen in den einzelnen Fermenterbereichen behindernde periodische Rückströmen verzichtet werden kann. embedded image

3.WO/2022/010342PROTECTIVE SOLUTION FOR ISOLATING MITOCHONDRIA, USE THEREOF, KIT COMPRISING THE SAME, AND METHOD FOR ISOLATING MITOCHONDRIA
WO 13.01.2022
Int.Class C12N 5/07
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
Appl.No PCT/MY2021/050056 Applicant LOH, Hui Ling Inventor CHENG, Han-Chung
The embodiments according to the present disclosure provide a protective solution, a kit, and a method for isolating mitochondria. The kit includes an extraction tube, a protective solution, and a suction needle. The extraction tube is used to contain cells. The protection solution is used to mix with the cells in the extraction tube to form a mixture solution, and the osmolarity of the protective solution is greater than 0 and less than or equal to 220 moms'/L. The suction needle is used to suck the mixed solution back and forth to facilitate the release of mitochondria from cells. This method and the protective solution may isolate mitochondria from cells with high efficiency in a simple and convenient way, and the isolated mitochondria have excellent good function.
4.WO/2022/008536CLARIFICATION SETUP OF A BIOPROCESSING INSTALLATION
WO 13.01.2022
Int.Class C12M 1/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
Appl.No PCT/EP2021/068706 Applicant SARTORIUS STEDIM BIOTECH GMBH Inventor SABALLUS, Martin
The invention is directed to a clarification setup of a bioprocessing installation for the clarification of a cell broth by centrifugation and subsequent filtration, wherein, for the centrifugation, the clarification setup comprises a centrifuge (1), wherein the centrifuge (1) comprises at least one centrifuge chamber (2) with a chamber inlet (3) and a chamber outlet (4), wherein the clarification setup comprises a liquid pumping arrangement (5) assigned to the centrifuge (1) and a liquid network (6) with a number of liquid lines (7) communicating with the liquid pumping arrangement (5), wherein the clarification setup comprises a process control (8) for controlling at least the centrifuge (1) and the liquid pumping arrangement (5). It is proposed that for filtration, the clarification setup comprises a filter arrangement (9), that the liquid network (6) provides an outlet supernatant line (10) for a liquid connection between the chamber outlet (4) and the filter arrangement (9), which is at least temporarily, preferably permanently, liquid-tight, such that due to this liquid-tight condition of the outlet supernatant line (10) the liquid pumping arrangement (5) as such may drive the supernatant from the chamber outlet (4) to the filter arrangement (9) via the outlet supernatant line (10).
5.WO/2022/010982MICROSCALE BIOREACTOR SYSTEM FOR AND METHOD OF PROVIDING CELL CULTURE GROWTH CONDITIONS IN A SMALL-VOLUME VESSEL
WO 13.01.2022
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/US2021/040635 Applicant REDBUD LABS, INC. Inventor GURNEY, Travis
A microscale bioreactor system for and method is disclosed for providing improved cell culture growth conditions in a small-volume vessel. For example, a microbioreactor system is provided that may include a small-volume vessel and wherein the small-volume vessel may include a field of actuatable surface-attached microposts. Further, the microbioreactor system may include an actuation mechanism for actuating the surface-attached microposts into movement. In some embodiments, the surface-attached microposts may be functionalized with, for example, activation signals for converting standard T-cells in a growth media to activated T-cells. Further, a method of using the microbioreactor system for providing cell culture growth conditions including enhanced oxygenation and nutrients distribution in a small-volume vessel is provided.
6.WO/2022/009663MIGRATION ABILITY CALCULATION DEVICE, MIGRATION ABILITY EVALUATION METHOD, AND COMPUTER PROGRAM FOR CAUSING COMPUTER TO EXECUTE MIGRATION ABILITY EVALUATION METHOD
WO 13.01.2022
Int.Class C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
Appl.No PCT/JP2021/023586 Applicant NIKON CORPORATION Inventor TAKASAKI Tetsuomi
The first aspect of the present invention provides a migration ability evaluation method comprising: a trajectory generation step of generating a trajectory of movement of an object being observed of a living body on the basis of a plurality of images of the object being observed acquired by capturing observation images of the object being observed multiple times in a time-series manner; a migration ability calculation step of calculating a migration ability measure indicating the degree of migration of the object being observed in a certain direction on the basis of the trajectory of movement of the object being observed; and a migration ability evaluation step of evaluating whether or not the object being observed satisfies a predetermined condition on the basis of the migration ability measure of the object being observed.
7.WO/2022/008478PROCESS FOR PRODUCING SINGLE CELL PROTEIN
WO 13.01.2022
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/EP2021/068582 Applicant UNIBIO A/S Inventor NANDY, Subir, Kumar
The present invention relates to a process for providing a first reaction product by a first fermentation process conducted in a first Loop reactor, the method comprising the steps of: (i) adding an inoculum comprising one or more methanogenic microorganism to the first Loop reactor providing a first inoculated fermentation medium; (ii) adding a gaseous hydrogen (H2) to the first inoculated fermentation medium; (iii) adding a first carbon source to the first inoculated fermentation medium; (iv) allowing the first fermentation medium to ferment, providing the first reaction product; and (v) isolating the first reaction product provided in step (iv).
8.WO/2022/008733MICROFLUIDIC CELL CULTURE DEVICE
WO 13.01.2022
Int.Class C12M 1/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
32multiple field or continuous type
Appl.No PCT/EP2021/069205 Applicant MIMETAS B.V. Inventor TRIETSCH, Sebastiaan Johannes
A microfluidic cell culture device is described. The device comprises a microfluidic network comprising a base, a microfluidic channel, and a cover, and at least one perfusion compartment and at least one support compartment inside the microfluidic channel. The base and cover each comprise an aperture, thereby defining a conduit through the microfluidic channel. The aperture is in fluidic contact with the at least one support compartment, and with the at least one perfusion compartment through the at least one support compartment. Methods for creating a fluid-fluid interface and for investigating a cellular response to a stimulant using the device are also described.
9.WO/2022/010473MEASURING DEFORMABILITY OF A CELL VIA A PRESSURE FIELD
WO 13.01.2022
Int.Class G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
49blood
Appl.No PCT/US2020/041232 Applicant HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. Inventor D'APUZZO, Fausto
An example method for measuring deformability of a cell via a pressure field, consistent with the present disclosure, includes flowing a biologic sample containing a plurality of cells along a first fluidic channel and into an intersection between the first fluidic channel and a second fluidic channel of a microfluidic device. The method includes introducing a pressure field at the intersection and into the first fluidic channel via the second fluidic channel and a plurality of apertures in a channel wall disposed in the intersection. The method further includes measuring deformability of a cell among the plurality of cells responsive to the introduction of the pressure field.
10.WO/2022/011163SUPPORT AND SYSTEM FOR ENGINEERED TISSUE
WO 13.01.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/US2021/040923 Applicant NOVOHEART LIMITED Inventor ROBERTS, Erin, G.
The present disclosure relates to tissue supports for use with engineered tissues and organoids, such as cardiac organoid chambers. In an embodiment of the present disclosure, the tissue supports are provided with a fluid-impermeable resilient member that is resiliently deformable during testing by cultured tissues formed on the surface of the tissue support.