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Analysis

1.WO/2022/011001METHOD FOR ANTIGEN DETECTION FROM DIRECT CLINICAL SAMPLES
WO 13.01.2022
Int.Class A61K 39/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
04Mycobacterium, e.g. Mycobacterium tuberculosis
Appl.No PCT/US2021/040672 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor RODWELL, Timothy
In one aspect, the disclosure relates to test strips for detecting and/or monitoring the treatment of a disease in a subject. The test strips are inexpensive and disposable and can be used directly with clinical biological samples from patients including, but not limited to, blood, plasma, saliva, and urine. Also disclosed are methods of using the test strips to quantify antigens produced by a virus or microorganism causing an infectious disease. The methods can be conducted at a point of care for a patient and do not require expensive equipment or extensive operator training. The methods are also rapid to complete and can be used to monitor progress in the treatment of a disease This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
2.WO/2022/011332IMMUNOGENIC COMPOSITION FORMING A VACCINE, AND A METHOD FOR ITS MANUFACTURE
WO 13.01.2022
Int.Class A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Appl.No PCT/US2021/041245 Applicant ENGIMATA, INC Inventor MOSHARRAF, Mitra
An immunogenic composition forming a vaccine includes a nanoparticle adjuvant comprising at least a nanoparticle, wherein the at least a nanoparticle comprises a lipid layer exterior including a plurality of lipids, cholesterol, and a primary alkyl amine including a positively charged amino group head and at least a carbon tail and an antigen incorporated in the at least a nanoparticle, wherein the antigen comprises a spike protein from a coronavirus.
3.WO/2022/010353METHODS FOR IDENTIFYING CORONAVIRUS CROSS-REACTING ANTIBODIES
WO 13.01.2022
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No PCT/NL2021/050435 Applicant LEYDEN LABORATORIES B.V. Inventor GOUDSMIT, Jaap
The disclosure provides methods for identifying coronavirus cross-reacting antibodies. Such antibodies bind to at least part of the S2 ectodomain of the S protein of at least one common human coronavirus selected from HCoV-NL63, HCoV-OC43, HCoV-229E and HCoV-HKU1 and bind to at least part of the S2 ectodomain of the S protein of at least one highly pathogenic human coronavirus selected from SARS-CoV- 1, MERS-CoV and SARS-CoV-2. Antibodies identified by the methods described herein are particularly useful for treating or preventing coronaviral infections, in particular against highly pathogenic coronaviruses such as SARS-CoV-1, MERS-CoV and/or SARS-CoV-2 as well as cross-species transmission of typically non-human coronaviruses.
4.WO/2022/011210TREATMENT FOR SEVERE ACUTE RESPIRATORY ILLNESS ASSOCIATED WITH CORONAVIRUS
WO 13.01.2022
Int.Class A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
Appl.No PCT/US2021/041004 Applicant DOWNING, Sean Inventor DOWNING, Sean
A method is provided for identifying a patient having a respiratory illness and administering to the patient a combination of an anti-inflammatory agent and a leukotriene inhibitor. The method may include treating respiratory illness associated with a coronavirus, and may it may further include reducing or preventing an inflammatory response or cytokine storm for those patients without impairing their immune response against the underlying pathogen.
5.WO/2022/011021USE OF CONSERVED PEPTIDE EPITOPES FROM SARS-COV-2 FOR THE DEVELOPMENT OF A BROAD COVID-19 VACCINE
WO 13.01.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2021/040700 Applicant ASCENDO BIOTECHNOLOGY, INC. Inventor LU, Yen-Ta
A vaccine for generation of immunity against SARS-CoV-2 infection includes an S2'-peptide of SARS-CoV-2 in a formulation that enhances immune responses, wherein the S2'-peptide includes the amino acid sequence selected from SEQ ID NO: 1-10. The formulation includes nanocomplexes encapsulating the S2'-peptide, or the formulation includes TREM-like transcript-1 (TREML1) extracellular domain (ECD) or a stalk peptide as an immune booster.
6.WO/2022/007905NOVEL VACCINE ADJUVANT AND USE THEREOF IN NOVEL CORONAVIRUS VACCINES AND OTHER VACCINES
WO 13.01.2022
Int.Class A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Appl.No PCT/CN2021/105297 Applicant TSINGHUA UNIVERSITY Inventor LI, Yanmei
The present invention relates to the field of biomedicine, and in particular to a novel vaccine adjuvant and the use thereof in novel coronavirus disease vaccines and other vaccines. A chemically modified cyclic dinucleotide, i.e. an SF compound, can be used as a vaccine adjuvant to be combined with the novel coronavirus disease vaccines.
7.WO/2022/010860INFECTIOUS RECOMBINANT VESICULAR STOMATITIS VIRUS (RVSV) BEARING THE SPIKE GLYCOPROTEIN S OF SARS-COV-2 AND USES THEREOF
WO 13.01.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2021/040460 Applicant ALBERT EINSTEIN COLLEGE OF MEDICINE Inventor CHANDRAN, Kartik
Provided herein are recombinant vesicular stomatitis virus (rVSV) or rVSV vector comprising nucleic acid encoding the spike glycoprotein S of SARS-COV-2, compositions comprising such vectors or viruses, as well as screening methods, diagnostic methods, prophylactic and therapeutic methods using such vectors or viruses.
8.WO/2022/003719POLYPEPTIDE FRAGMENTS, IMMUNOGENIC COMPOSITION AGAINST SARS-CoV-2, AND IMPLEMENTATIONS THEREOF
WO 06.01.2022
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/IN2021/050631 Applicant INDIAN INSTITUTE OF SCIENCE Inventor VARADARAJAN, Raghavan
The present disclosure discloses the polypeptide fragment having an amino acid sequence with at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, and SEQ ID NO: 6. The present disclosure also discloses nucleic acid fragment encoding the polypeptide fragment as described herein. Moreover, the present disclosure also discloses recombinant construct, recombinant vector and recombinant host cells. Also disclosed herein is an immunogenic composition comprising the polypeptide fragment as described herein, and a method for preparing the said immunogenic composition. The immunogenic composition is in form of vaccine. The polypeptide fragment and/or immunogenic composition is capable of eliciting protection against severe acute respiratory syndrome coronavirus 2. A kit comprising the polypeptide, or the immunogenic composition as described herein is also disclosed.
9.WO/2022/006565POLYPEPTIDES, VACCINE COMPOSITIONS, AND USE THEREOF FOR INDUCING IMMUNE RESPONSE TO SARS-COV-2 IN PRIMATES
WO 06.01.2022
Int.Class A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Appl.No PCT/US2021/040583 Applicant ZHANG, Kang Inventor ZHANG, Kang
Disclosed herein, in some embodiments, are methods and compositions for inducing an immune response against SARS-CoV -2 in a primate in need thereof with a recombinant polypeptide, wherein the at least a portion of the recombinant polypeptide corresponds to an amino acid residue sequence within the Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein capable of forming a binding interface that interacts with a viral receptor of the primate.
10.WO/2022/006146YEAST-BASED VACCINES
WO 06.01.2022
Int.Class A61K 35/66
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
Appl.No PCT/US2021/039671 Applicant THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Inventor CORNISH, Virginia
The disclosed subject matter provides for vaccines against coronaviruses comprising one or more fungal cells genetically engineered to secrete an antigen derived from a coronavirus, e.g., SARS-CoV-2, in situ, and methods of use thereof.