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Analysis

1.WO/2022/011271PROBIOTICS FOR USE IN THE PREVENTION OR TREATMENT OF ILLNESS AND/OR SYMPTOMS ASSOCIATED WITH CORONAVIRUSES
WO 13.01.2022
Int.Class A61K 35/74
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
Appl.No PCT/US2021/041103 Applicant DUPONT NUTRITION BIOSCIENCES APS Inventor GUERY, Sebastien
This invention relates to bacterial strains, compositions comprising bacterial strains as well as methods and uses of said strains and compositions for 1) preventing or treating illness and/or symptoms associated with a coronavirus in a subject in need thereof and/or 2) prolonging immunity against a disease caused by a coronavirus in a subject in need thereof after the subject has previously a) been exposed to the coronavirus; b) recovered from a disease caused by infection with the coronavirus; and/or c) been vaccinated against the coronavirus.
2.20220008508RELAXIN RECEPTOR 1 FOR USE IN TREATMENT AND PREVENTION OF HEART FAILURE
US 13.01.2022
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No 17294350 Applicant Universität Heidelberg Inventor Hugo KATUS

The present invention relates to a polynucleotide comprising an expressible nucleic acid sequence encoding a relaxin family peptide receptor (RXFP) polypeptide for use in treatment and/or prevention of heart failure in a subject. The present invention further relates to a vector comprising the polynucleotide of the present invention for use in treatment and/or prevention of heart failure, as well as to host cells, RXFP agonists, kits and devices related thereto.

3.20220008529MULTI-FUNCTIONALIZED noMV CONJUGATES
US 13.01.2022
Int.Class A61K 39/095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
095Neisseria
Appl.No 16636560 Applicant GLAXOSMITHKLINE BIOLOGICALS SA Inventor Renzo ALFINI

The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

4.20220008357EYE HEALTH SUPPLEMENT WITH CURCUMIN
US 13.01.2022
Int.Class A61K 31/065
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
065Diphenyl-substituted acyclic alcohols
Appl.No 17448513 Applicant QH Holdings (Oregon), Inc. Inventor James Stringham

An eye health supplement and methods of using the eye health supplement are disclosed.

5.20220008528COMPOSITION FOR PREVENTING OR TREATING BENIGN TUMOR
US 13.01.2022
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Appl.No 17282172 Applicant International Institute of Cancer Immunology, Inc. Inventor Haruo SUGIYAMA

The present disclosure provides a composition for preventing or treating a benign tumor. Provided is a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a specific embodiment, the present disclosure provides a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a preferred embodiment, the composition for preventing or treating a benign tumor (e.g. familial adenomatous polyposis) according to the present disclosure comprises a killer type WT1 peptide and/or a helper type WT1 peptide. In a further preferred embodiment, the WT1 peptide is WT1126 killer peptide and/or WT135 helper peptide. In another aspect, provided are a method of inducing WT1 peptide-specific CTLs, a method of inducing WT1-specific helper T cells, and a method of inducing dendritic cells presenting a WT1 peptide.

6.WO/2022/007081TRADITIONAL CHINESE MEDICINE COMPOUND FORMULATION FOR TREATMENT OF PARKINSON’S DISEASE, PREPARATION METHOD THEREFOR AND USE THEREOF
WO 13.01.2022
Int.Class A61K 36/8988
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
898Orchidaceae (Orchid family)
8988Gastrodia
Appl.No PCT/CN2020/106957 Applicant YAOSHUNZE BIO-MEDICAL (NANJING) CO., LTD. Inventor GU, Xiaosong
A traditional Chinese medicine compound formulation for treatment of Parkinson's disease, a preparation method therefor, and a use thereof. The traditional Chinese medicine formulation comprises traditional Chinese medicine formula components. The traditional Chinese medicine formula components comprise the following raw materials or raw material extracts in parts by mass: 6-15 parts Uncaria rhynchophylla, 3-9 parts Gastrodia elata, 6-12 parts Gentiana macrophylla, 10-20 parts Astragalus mongholicus Bunge, 10-20 parts Radix Rehmanniae preparata, 10-20 parts Radix Achyranthis Bidentatae, 10-20 parts Fructus lycii, 10-20 parts Radix Angelicae Sinensis, 10-20 parts stir-baked Rhizoma Atractylodis Macrocephalae, 6-15 parts stir-baked Semen Ziziphi Spinosae, 3-12 parts Semen persicae, 3-9 parts safflower, and 20-30 parts Zaocys dhumnades. The compound formulation is a multi-layered, multi-targeted treatment based on syndrome differentiation taking into consideration of the onset and development of Parkinson's disease, overall patient function, and the principle of “deficiency in origin and excess in superficiality.” The present invention not only has a theoretical basis in modern science, but also has good clinical results, and clearly improves patient quality of life.
7.WO/2022/008251PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF VITILIGO
WO 13.01.2022
Int.Class A61K 35/618
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
Appl.No PCT/EP2021/067203 Applicant BELLA AURORA LABS, S.A. Inventor BORDIGNON, Matteo
The present invention relates to a pharmaceutical composition for the treatment of vitiligo comprising the combination of a peptide which is an inhibitor of the melanoma inhibitory activity (MIA) protein and snail secretion. The invention also relates to a kit comprising this composition and a dietary supplement comprising an antioxidant. The invention also relates to the use of the composition or to the use of the kit comprising such composition for the prevention and/or treatment of vitiligo.
8.WO/2022/009136METHOD OF ENCAPSULATION OF AN ACTIVE PROTEIN USING ELECTRODEPOSITION TECHNIQUES, AN ANTIBACTERIAL COMPOSITION CONTAINING THE ACTIVE PROTEIN AND A POLYMER, AND ITS USE FOR THE PRODUCTION OF VETERINARY MEDICINAL PRODUCTS
WO 13.01.2022
Int.Class A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Appl.No PCT/IB2021/056130 Applicant BIOCELTIX SPOLKA AKCYJNA Inventor BZDZION, Lukasz
The subject of invention is a method of encapsulating an active protein using electrodeposition techniques, characterised in that it comprises the following steps: (a) establishing a primary mesenchymal cell culture containing 2,000-5,000 source tissue cells and a serum-supplemented culture medium; (b) maintaining the cell culture established in step (a) for 280-340 hours until the culture surface is fully covered by the cultured cells; (c) obtaining a culture fluid from the above of the cultured cells; (d) purifying the culture fluid obtained in step (c) from cell debris and suspended cells by centrifuging said fluid with a force of 300 to 1200 x g; (e) transferring the upper liquid phase from above the sediment to a new vessel; (f) gently mixing the purified liquid phase obtained in step (e) with an aqueous solution of polyvinyl alcohol; (g) adding ethyl alcohol to the mixture obtained in step (f) while stirring continuously; (h) the material obtained in step (g) is deposited on the collector surface by means of electro spinning or electrospraying. Another subject of invention is an antibacterial composition containing an active protein and a polymer, characterised in that it contains ethyl alcohol, wherein the active protein is a fibrous, fully water-soluble material containing proteins released by mesenchymal cells, including cathelicidin at an amount from 270 to 1230 pg/100mg of dry weight of the composition, and the polymer is an aqueous solution of polyvinyl alcohol. Another subject of invention is an use of the antibacterial composition according to invention for the preparation of veterinary medicinal products.
9.WO/2022/009211METHODS FOR TREATING ACUTE RESPIRATORY INFLAMMATORY CONDITIONS AND CYTOKINE STORM SYNDROME
WO 13.01.2022
Int.Class C12N 5/07
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
Appl.No PCT/IL2021/050841 Applicant REMEDY CELL LTD. Inventor SHAKED, Yuval
Methods of treating, ameliorating or preventing an acute respiratory disease or condition or cytokine storm in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising an effective amount of MSCs contacted with chemotherapy or conditioned media from the MSCs contacted with chemotherapy are provided.
10.WO/2022/011311METHODS OF PROTECTING CELLS FROM INSULTS
WO 13.01.2022
Int.Class A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Appl.No PCT/US2021/041172 Applicant MUSC FOUNDATION FOR RESEARCH DEVELOPMENT Inventor YOST, Michael
Described herein are methods for preventing non-insulted cell damage during a subject's exposure to radiation. In some embodiments, the method can include administering an amount of poloxamer 188 or a pharmaceutical formulation thereof to a subject prior to exposure to an insult.