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1. WO2021154687 - METHODS FOR TREATING SARS COV-2 INFECTIONS

Publication Number WO/2021/154687
Publication Date 05.08.2021
International Application No. PCT/US2021/015027
International Filing Date 26.01.2021
IPC
A61K 31/7056 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
7056containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/706 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61K 31/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 31/685
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 31/7056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
7056containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/706
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants
  • GILEAD SCIENCES, INC. [US]/[US]
Inventors
  • CIHLAR, Tomas
  • OSINUSI, Anuoluwapo
  • PORTER, Danielle L.
Agents
  • BAJPAI, Reena
  • AMIRGHOLIZADEH, Tashica T.
  • BOSS, Brandon
  • BRINKER, Achim
  • CHEN, Wenlan
  • CHOI, Lydia B.
  • DAMMANN, Yu-Ming
  • DOZZO, Paola
  • EDWARDS, Mary J.
  • GHOSH, Samantak
  • GINAH, Francis O.
  • GRESSLER, Donna
  • HARTRUM, J. Elin
  • HUTCHISON, Andrea
  • LAI, Shelley
  • LIU, Jiangqiong
  • MARQUART, Timothy A.
  • POLSTER, Philip B.
  • RICE, Katharine R.
  • SILVER, Joel
  • SIMPSON, Alexis N.
  • STUART, Tara C.
  • WAHLSTEN, Jennifer L.
  • YANG, Liuchun
Priority Data
62/966,44027.01.2020US
62/976,67114.02.2020US
62/985,19404.03.2020US
63/031,37328.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING SARS COV-2 INFECTIONS
(FR) PROCÉDÉS DE TRAITEMENT D'INFECTIONS PAR SRAS COV-2
Abstract
(EN) Provided are methods for treating 2019-nCoV virus (SARS-CoV-2) infections by administering nucleosides and prodrugs thereof, of Formula (I), wherein the 1 ' position of the nucleoside sugar is substituted.
(FR) L'invention concerne des procédés de traitement d'infections par le virus 2019-nCoV (SRAS-CoV-2) par l'administration de nucléosides et promédicaments correspondants, de formule I dans laquelle la position 1' du sucre nucléosidique est substituée.
Latest bibliographic data on file with the International Bureau