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1. WO2021003196 - METHODS, APPARATUS AND PRODUCTS OF CELL, TISSUE ENGINEERING AND VACCINE/ANTIBODY PRODUCTION SYSTEMS

Publication Number WO/2021/003196
Publication Date 07.01.2021
International Application No. PCT/US2020/040377
International Filing Date 30.06.2020
IPC
B65G 65/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
GTRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
65Loading or unloading
H01L 21/67 2006.1
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
LSEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR
21Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
67Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereof; Apparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
H01L 21/677 2006.1
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
LSEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR
21Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
67Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereof; Apparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
677for conveying, e.g. between different work stations
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12M 21/08
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
21Bioreactors or fermenters specially adapted for specific uses
08for producing artificial tissue or for ex-vivo cultivation of tissue
C12M 23/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
23Constructional details, e.g. recesses, hinges
02Form or structure of the vessel
16Microfluidic devices; Capillary tubes
C12M 25/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
25Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
14Scaffolds; Matrices
C12M 29/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
29Means for introduction, extraction or recirculation of materials, e.g. pumps
04Filters; Permeable or porous membranes or plates, e.g. dialysis
Applicants
  • FUTRFAB, INC [US]/[US]
Inventors
  • FLITSCH, Frederick
Agents
  • KINCART, Joseph
  • FLITSCH, Frederick
Priority Data
62/869,33501.07.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS, APPARATUS AND PRODUCTS OF CELL, TISSUE ENGINEERING AND VACCINE/ANTIBODY PRODUCTION SYSTEMS
(FR) PROCÉDÉS, APPAREIL ET PRODUITS DE CELLULES, GÉNIE TISSULAIRE ET SYSTÈMES DE PRODUCTION DE VACCIN/ANTICORPS
Abstract
(EN) The present invention provides apparatus and methods for production of tissue structures, organs, vaccines and antibody products. In some examples, a cleanspace facility may be equipped with fluid interconnections and controls. The fluid interconnections may be located in a primary cleanspace or peripheral to a primary cleanspace. Sterilization may be performed within the primary cleanspace and within the fluid interconnections. In some examples, the facility may include modelling hardware and software, nanotechnology and microelectronic apparatus, and additive manufacturing equipment to print cells and support matrix to allow cells to grow into tissue structures and organs. Novel structures combining various cell types and electronics may be formed with the fabricator. In some examples, advanced vaccine products may be produced entirely within the scalable, sterile and automated fabricator.
(FR) La présente invention concerne un appareil et des procédés de production de structures et d'organes tissulaires, de produits de vaccins et d'anticorps. Dans certains exemples, une installation de salle blanche peut être équipée d'interconnexions et de commandes de fluide. Les interconnexions de fluide peuvent être situées dans une salle blanche primaire ou périphériques par rapport à une salle blanche primaire. La stérilisation peut être effectuée à l'intérieur de la salle blanche primaire et à l'intérieur des interconnexions de fluide. Dans certains exemples, une installation peut être équipée d'un matériel et d'un logiciel de modélisation, d'une nanotechnologie et d'un appareil microélectronique, et d'un équipement de fabrication additive pour imprimer des cellules et une matrice de support pour permettre aux cellules de croître dans des structures et des organes tissulaires. De nouvelles structures combinant divers types de cellules et de l'électronique peuvent être formées avec le dispositif de fabrication. Dans certains exemples, des produits de vaccin avancés peuvent être produits entièrement dans le dispositif de fabrication évolutif, stérile et automatisé.
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