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1. WO2020033934 - SMART FLOW CYTOMETERS WITH SELF MONITORING AND SELF VALIDATION

Publication Number WO/2020/033934
Publication Date 13.02.2020
International Application No. PCT/US2019/046071
International Filing Date 10.08.2019
IPC
G01N 15/02 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
02Investigating particle size or size distribution
G01N 15/06 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
06Investigating concentration of particle suspensions
G01N 15/10 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
G01N 15/14 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation
CPC
G01N 15/1012
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
1012Calibrating particle analysers; References therefor
G01N 15/1425
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1425using an analyser being characterised by its control arrangement
G01N 15/1431
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1429using an analyser being characterised by its signal processing
1431the electronics being integrated with the analyser, e.g. hand-held devices for on-site investigation
G01N 15/1434
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1434using an analyser being characterised by its optical arrangement
G01N 15/1459
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1456without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
1459the analysis being performed on a sample stream
G01N 2015/1006
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
1006for cytology
Applicants
  • CYTEK BIOSCIENCES, INC. [US/US]; 46107 Landing Parkway Fremont, California 94538, US
Inventors
  • JIANG, Janine; US
  • VRANE, David; US
Agents
  • ALFORD, William; US
Priority Data
16/101,38510.08.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SMART FLOW CYTOMETERS WITH SELF MONITORING AND SELF VALIDATION
(FR) CYTOMÈTRES DE FLUX INTELLIGENTS AVEC AUTO-SURVEILLANCE ET AUTO-VALIDATION
Abstract
(EN)
In some embodiments, a smart flow cytometer includes a monitoring system to monitor differing operational parameters of the smart flow cytometer to detect an advanced failure of components and an advanced need for maintenance. In others, a smart flow cytometer includes a quality control system including a reservoir of quality control beads to periodically run a validation test with the quality control beads in order to determine the ability of the flow cytometer to generate quality data output from a plurality of light detectors. In some embodiments, a plurality of smart flow cytometers are coupled into communication with a computer communication network; a central repair server system is coupled into communication with the computer communication network and the plurality of smart flow cytometers; wherein each of the plurality of smart flow cytometers includes a monitoring system coupled to monitor differing operational parameters of the smart flow cytometer for possible failure.
(FR)
Selon l'invention, dans certains modes de réalisation, un cytomètre de flux intelligent comprend un système de surveillance pour surveiller différents paramètres de fonctionnement du cytomètre de flux intelligent pour détecter une défaillance avancée de composants et un besoin avancé de maintenance. Dans d'autres modes de réalisation, un cytomètre de flux intelligent comprend un système de contrôle qualité comprenant un réservoir de billes de contrôle qualité pour exécuter périodiquement un test de validation à l'aide des billes de contrôle qualité afin de déterminer la capacité du cytomètre de flux à générer une sortie de données de qualité à partir d'une pluralité de détecteurs de lumière. Dans certains modes de réalisation, une pluralité de cytomètres de flux intelligents sont couplés en communication avec un réseau de communication informatique ; un système serveur de réparation central est couplé en communication avec le réseau de communication informatique et la pluralité de cytomètres de flux intelligents ; chacun de la pluralité de cytomètres à flux intelligent comprend un système de surveillance couplé pour surveiller différents paramètres de fonctionnement du cytomètre de flux intelligent concernant une éventuelle défaillance.
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