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1. WO2020033731 - POLYPEPTIDE INTEGRIN ANTAGONISTS

Publication Number WO/2020/033731
Publication Date 13.02.2020
International Application No. PCT/US2019/045762
International Filing Date 08.08.2019
IPC
C07K 14/78 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 7/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64Cyclic peptides containing only normal peptide links
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, Massachusetts 02114, US
  • ARNAOUT, M. Amin [US/US]; US
Inventors
  • ARNAOUT, M. Amin; US
Agents
  • DAVEY, Evan, A.; US
  • FOLLETT, PH.D., Angela D.; US
Priority Data
62/715,86008.08.2018US
62/757,12607.11.2018US
62/786,80431.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYPEPTIDE INTEGRIN ANTAGONISTS
(FR) ANTAGONISTES DE L'INTÉGRINE POLYPEPTIDIQUE
Abstract
(EN)
The present application relates to polypeptides which are integrin antagonists. Methods of preparing the integrin antagonists and methods of treating diseases and disorders associated with abnormal levels and/or expression of one or more integrins are also provided.
(FR)
La présente invention concerne des polypeptides qui sont des antagonistes de l'intégrine. L'invention concerne également des procédés de préparation des antagonistes de l'intégrine et des procédés de traitement de maladies et de troubles associés à des niveaux et/ou une expression anormaux d'une ou de plusieurs intégrines.
Latest bibliographic data on file with the International Bureau