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1. WO2020032324 - ANTIBIOTIC PEPTIDE TARGETING TOXIN-ANTITOXIN SYSTEM OF STREPTOCOCCUS PNEUMONIAE, AND USE THEREOF

Publication Number WO/2020/032324
Publication Date 13.02.2020
International Application No. PCT/KR2018/013791
International Filing Date 13.11.2018
IPC
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
Applicants
  • 서울대학교 산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR/KR]; 서울시 관악구 관악로 1 1, Gwanak-ro Gwanak-gu Seoul 08826, KR
Inventors
  • 이봉진 LEE, Bong-Jin; KR
  • 김도희 KIM, Do-Hee; KR
  • 강성민 KANG, Sung-Min; KR
Agents
  • 이원희 LEE, Won Hee; KR
Priority Data
10-2018-009396910.08.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) ANTIBIOTIC PEPTIDE TARGETING TOXIN-ANTITOXIN SYSTEM OF STREPTOCOCCUS PNEUMONIAE, AND USE THEREOF
(FR) PEPTIDE ANTIBIOTIQUE CIBLANT UN SYSTÈME TOXINE-ANTITOXINE DE STREPTOCOCCUS PNEUMONIAE, ET UTILISATION ASSOCIÉE
(KO) 폐렴구균의 독소-항독소 체계를 표적으로 하는 항생 펩타이드 및 이의 용도
Abstract
(EN)
The present invention relates to an antibiotic peptide targeting the toxin-antitoxin system of Streptococcus pneumoniae, and a use thereof. Specifically, an antibiotic peptide of the present invention inhibits the formation of a toxin-antitoxin complex of Streptococcus pneumoniae, without affecting the active site of the toxin, so as to induce the killing of Streptococcus pneumoniae by means of the RNA degradation activity of an isolated toxin, and also exhibits antibiotic activity against other bacteria, thereby being effectively usable as an antibiotic composition.
(FR)
La présente invention concerne un peptide antibiotique ciblant un système toxine-antitoxine de streptococcus pneumoniae, et une utilisation associée. Plus particulièrement, un peptide antibiotique selon la présente invention inhibe la formation d'un complexe toxine-antitoxine de Streptococcus Pneumoniae, sans affecter le site actif de la toxine, de manière à induire la destruction de Streptococcus Pneumoniae au moyen de l'activité de dégradation de l'ARN d'une toxine isolée, et présente également une activité antibiotique contre d'autres bactéries, ce qui peut être utilisé de manière efficace en tant que composition antibiotique.
(KO)
본 발명은 폐렴구균의 독소-항독소 체계를 표적으로 하는 항생 펩타이드 및 이의 용도에 관한 것으로, 구체적으로 본 발명의 항생 펩타이드는 독소의 활성부위에는 영향을 미치지 않으면서 폐렴구균의 독소-항독소 복합체 형성을 억제하고, 그에 따라 분리된 독소의 RNA 분해 활성에 의해 폐렴구균의 사멸을 유도하며, 다른 균들에 대해서도 항생 활성을 나타내므로, 항생용 조성물로 유용하게 사용될 수 있다.
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