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1. WO2020031099 - COMPOSITION CONTAINING A MUCOLYTIC AGENT FOR THE TREATMENT OF MUCUS HYPERSECRETION AND A DEVICE FOR THE DOSING THEREOF

Publication Number WO/2020/031099
Publication Date 13.02.2020
International Application No. PCT/IB2019/056710
International Filing Date 07.08.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61M 15/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
15Inhalators
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/0073
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
A61K 9/0075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0075for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
A61M 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
Applicants
  • SOFAR S.P.A. [IT]/[IT]
Inventors
  • BIFFI, Andrea
Agents
  • HOFFMANN EITLE S.R.L.
  • ZANGS, Rainer E.
  • KINDLER, Matthias
  • FRANK, Veit Peter
  • POLZ, Leo
  • STEIN-DRÄGER, Christiane
  • AVERY, Stephen John
  • LETHEM, David James
  • MARSH, Roy David
  • MITCHELL, Alan
  • FURLONG, Christopher Heinrich
  • BAUSCH, Thorsten
  • TAORMINO, Joseph Paul
  • KLUSMANN, Peter
  • SCHWEIGHART, Peter
  • WOLF, Matthias
  • SIEGERT, Georg
  • MAYRHOFER, Stefan
  • STRATMANN, Klemens
  • WIEDEMANN, Peter
  • VON KUROWSKI, Lorenz
  • BECHER, Claus Thomas
  • SPILGIES, Jan-Hendrik
  • RENKEN, Joachim
  • ENGELHARD, Elisabeth
  • BACHELIN, Karl Martin Raimund
  • DISSER, Stephan
  • VAN BOUWELEN, Franciscus Maria
  • FÜCHSLE, Kathrin
  • CIESLA, Ulrike
  • SCHÖN, Anne Katrin
  • VOCKE, Henrik
  • GÖRG, Andreas
  • GARBERG, Morten
  • RUSSELL, John Alistair
  • SPROSTON, David
  • THIRLWELL, Karen
  • SCHEIBLE, Dominik
  • VOS, Bianca-Lucia
  • DOUXCHAMPS, Nicolas
  • STEFFERL, Andreas
  • GOLLER, Daniel
  • PRUSS, Timo
  • WERNER-JONES, Leonard L.
  • BACCELLI, Michele
  • MÜLLER, Markus Georg
  • MUNCKE, Nadja
  • CORNEO, Giovanni
  • STREGE, Christine
  • DRAGOSAVAC, Marko
  • BIRKETT, Matthew
  • ZILLIES, Jan Carl
  • GROHS, Daniel
  • MULHERN, Declan
  • GRIMM, Stephan
  • TILLMANN, Volker
  • OGLE, James Matthew
  • GLAS, Johannes Dominik
  • STEINMÜLLER, Stephan
  • BENEDETTO, Marco
  • LEVINE, Benjamin
  • JONES, Mark A. G.
  • GRAEBER, Jens
  • FUSTER, Gustavo
  • ESSER, Axel T.
  • SCHIEREN, Roland
  • RECKENTHÄLER, Peter
  • CATANIA, Olivier
  • DÖRFEL, Katrin
  • WEINMANN, Lasse
  • SASSE, Stefan
  • MACHOTTA, Axel
  • SCHREIBER, Christian
  • WYDER, Thomas
  • WEIGEL-KRUSEMARCK, Michaela
  • MÜLLER, Michael
  • LEWIS, Debra Louise
  • PAETZOLD, Helge
  • SPIRKOSKA, Danche
Priority Data
10201800000792807.08.2018IT
Publication Language English (EN)
Filing Language Italian (IT)
Designated States
Title
(EN) COMPOSITION CONTAINING A MUCOLYTIC AGENT FOR THE TREATMENT OF MUCUS HYPERSECRETION AND A DEVICE FOR THE DOSING THEREOF
(FR) COMPOSITION CONTENANT UN AGENT MUCOLYTIQUE POUR LE TRAITEMENT DE L'HYPERSÉCRÉTION DE MUCUS ET DISPOSITIF POUR LE DOSAGE DE CELLE-CI
Abstract
(EN)
The present invention regards a composition in powder form for oral inhalation, preferably for oral aspiration, comprising a mucolytic agent, preferably N-acetylcysteine. Furthermore, the present invention regards said composition for use in a method for the treatment of a mucus hypersecretion and of diseases, symptoms or disorders associated with it in a needy subject. Lastly, the present invention regards a device for administration, through inhalation route by means of oral aspiration, to said needy subject.
(FR)
La présente invention concerne une composition sous forme de poudre pour inhalation orale, de préférence pour une aspiration orale, comprenant un agent mucolytique, de préférence la N-acétylcystéine. En outre, la présente invention concerne ladite composition destinée à être utilisée dans un procédé de traitement d'une hypersécrétion de mucus et de maladies, de symptômes ou de troubles associés à celle-ci chez un sujet nécessitant un tel traitement. Enfin, la présente invention concerne un dispositif d'administration, par voie d'inhalation au moyen d'une aspiration orale, audit sujet nécessitant un tel traitement.
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