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1. WO2020029860 - BISPECIFIC ANTIBODY AGAINST RABIES VIRUS, AND APPLICATION THEREOF

Publication Number WO/2020/029860
Publication Date 13.02.2020
International Application No. PCT/CN2019/098836
International Filing Date 01.08.2019
IPC
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 16/468
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
Applicants
  • 北京智仁美博生物科技有限公司 BEIJING WISDOMAB BIOTECHNOLOGY CO., LTD [CN/CN]; 中国北京市 经济技术开发区科创六街88号A3-501 Unit A3-501, No. 88 Kechuang 6th Street Beijing Economic and Techonological Development Area Beijing 101111, CN
  • 智翔(上海)医药科技有限公司 GENRIX (SHANGHAI) BIOPHARMACEUTICAL CO., LTD. [CN/CN]; CN
  • 重庆智翔金泰生物制药有限公司 CHONGQING GENRIX BIOPHARMACEUTICAL CO., LTD. [CN/CN]; CN
Inventors
  • 刘志刚 LIU, Zhigang; CN
  • 郝小勃 HAO, Xiaobo; CN
  • 刘玉兰 LIU, Yulan; CN
  • 郭晶晶 GUO, Jingjing; CN
Agents
  • 北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED; 中国北京市 海淀区知春路甲48号盈都大厦A座19A 19 A, Tower A, InDo Building No. 48A Zhichun Road, Haidian District Beijing 100098, CN
Priority Data
201810901518.009.08.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BISPECIFIC ANTIBODY AGAINST RABIES VIRUS, AND APPLICATION THEREOF
(FR) ANTICORPS BISPÉCIFIQUE CONTRE LE VIRUS DE LA RAGE ET SON APPLICATION
(ZH) 针对狂犬病病毒的双特异性抗体及其用途
Abstract
(EN)
The present application provides a bispecific antibody against rabies virus, and an application thereof. The bispecific antibody comprises two antigen-binding fragments binding to different epitopes of G protein of rabies virus, and has rabies virus neutralization activity.
(FR)
La présente invention concerne un anticorps bispécifique contre le virus de la rage, et une application de celui-ci. L'anticorps bispécifique comprend deux fragments de liaison à l'antigène se liant à différents épitopes de la protéine G du virus de la rage, et présente une activité de neutralisation du virus de la rage.
(ZH)
本申请提供了针对狂犬病病毒的双特异性抗体及其用途。所述双特异性抗体包含结合狂犬病病毒G蛋白不同表位的两个抗原结合片段,并且具有中和狂犬病病毒的活性。
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