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1. (WO2019013258) OPTICALLY CONTROLLED VIRUS PROTEIN, GENE THEREOF, AND VIRUS VECTOR CONTAINING SAID GENE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/013258 International Application No.: PCT/JP2018/026211
Publication Date: 17.01.2019 International Filing Date: 11.07.2018
IPC:
C12N 15/40 (2006.01) ,C07K 14/08 (2006.01) ,C07K 19/00 (2006.01) ,C12N 1/15 (2006.01) ,C12N 1/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01) ,C12N 15/62 (2006.01)
C CHEMISTRY; METALLURGY
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BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
31
Genes encoding microbial proteins, e.g. enterotoxins
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Genes encoding viral proteins
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Proteins from RNA viruses, e.g. flaviviruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
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Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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from viruses
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RNA viruses
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ORGANIC CHEMISTRY
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PEPTIDES
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Hybrid peptides
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MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
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1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
19
modified by introduction of foreign genetic material
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1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
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5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
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BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants:
国立大学法人 東京大学 THE UNIVERSITY OF TOKYO [JP/JP]; 東京都文京区本郷七丁目3番1号 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654, JP
Inventors:
谷 憲三朗 TANI, Kenzaburo; JP
佐藤 守俊 SATO, Moritoshi; JP
竹田 誠 TAKEDA, Makoto; JP
田原 舞乃 TAHARA, Maino; JP
Agent:
青木 篤 AOKI, Atsushi; JP
三橋 真二 MITSUHASHI, Shinji; JP
渡辺 陽一 WATANABE, Yoichi; JP
中島 勝 NAKAJIMA, Masaru; JP
武居 良太郎 TAKEI, Ryotaro; JP
津田 英直 TSUDA, Hidenao; JP
Priority Data:
2017-13557911.07.2017JP
Title (EN) OPTICALLY CONTROLLED VIRUS PROTEIN, GENE THEREOF, AND VIRUS VECTOR CONTAINING SAID GENE
(FR) PROTÉINE VIRALE À CONTRÔLE OPTIQUE, GÈNE CODANT POUR CELLE-CI ET VECTEUR VIRAL CONTENANT LEDIT GÈNE
(JA) 光制御性のウイルスタンパク質、その遺伝子、及びその遺伝子を含むウイルスベクター
Abstract:
(EN) The purpose of the present invention is to develop a virus vector, the activity of which is rendered controllable. A virus protein gene derived from an RNA virus is provided in which a gene encoding an optical switch protein is inserted into a foreign gene introducible region of the virus protein so as to enable expression of the gene. By means of this virus vector, it is possible to control, with irradiation of light, enzyme activity of the virus protein and virus vector activity based thereon.
(FR) L'objet de la présente invention est de développer un vecteur viral dont l'activité peut être contrôlée. Un gène codant pour une protéine virale dérivé d'un virus à ARN dans lequel un gène codant pour une protéine à commutation optique est inséré dans une région d'introduction de gène étranger de ladite protéine virale est utilisé de façon à permettre l'expression du gène. Ce vecteur viral permet de contrôler, par exposition à la lumière, l'activité enzymatique de la protéine virale et l'activité du vecteur viral basée sur celle-ci.
(JA) ウイルスベクターの活性の制御を可能とするウイルスベクターの開発を目的とする。ウイルスタンパク質の外来遺伝子導入可能領域に、光スイッチタンパク質をコードする遺伝子が発現可能に挿入された、RNAウイルス由来のウイルスタンパク質遺伝子を提供することによる。このウイルスベクターにより、ウイルスタンパク質の酵素活性並びにそれに基づくウイルスベクターの活性を、光の照射により制御できる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)