Processing

Please wait...

Settings

Settings

1. WO2018179302 - ANTI-PODOPLANIN ANTIBODY

Publication Number WO/2018/179302
Publication Date 04.10.2018
International Application No. PCT/JP2017/013488
International Filing Date 30.03.2017
IPC
C07K 16/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
36against blood coagulation factors
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C07K 14/745 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
C12N 1/15 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
15modified by introduction of foreign genetic material
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/745
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
C07K 16/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
36against blood coagulation factors
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
Applicants
  • 国立大学法人東北大学 TOHOKU UNIVERSITY [JP/JP]; 宮城県仙台市青葉区片平二丁目1番1号 2-1-1, Katahira, Aoba-ku, Sendai-shi, Miyagi 9808577, JP
  • ゼノアックリソース株式会社 ZENOAQ RESOURCE CO., LTD. [JP/JP]; 福島県郡山市安積町笹川字平ノ上1番地の1 1-1, Aza Tairanoue, Sasagawa, Asaka-machi, Koriyama-shi, Fukushima 9630196, JP
Inventors
  • 加藤 幸成 KATO, Yukinari; JP
  • 加藤 美華 KATO, Mika; JP
  • 山田 慎二 YAMADA, Shinji; JP
  • 小笠原 諭 OGASAWARA, Satoshi; JP
  • 中村 卓郎 NAKAMURA, Takuro; JP
Agents
  • 稲葉 良幸 INABA, Yoshiyuki; JP
  • 大貫 敏史 ONUKI, Toshifumi; JP
Priority Data
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTI-PODOPLANIN ANTIBODY
(FR) ANTICORPS ANTI-PODOPLANINE
(JA) 抗ポドプラニン抗体
Abstract
(EN)
The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof. The anti-podoplanin antibody is against the amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the sequence having an epitope in a region including Thr85, the Thr85 having a sialic acid-containing O-type sugar chain attached thereto.
(FR)
L'invention fournit un anticorps anti-podoplanine spécifique de cellules cancéreuses ou un fragment de liaison d'antigène de celui-ci, lequel anticorps anti-podoplanine possède un épitope dans une région contenant une Thr85 dans une séquence d'acides aminés d'une podoplanine humaine représentée par SEQ ID NO:1. Une chaîne de sucre de type O comprenant un acide sialique est ajoutée à la Thr85.
(JA)
本発明は、配列番号:1で表されるヒトポドプラニンのアミノ酸配列におけるThr85を含む領域にエピトープを有し、Thr85はシアル酸含有O型糖鎖が付加されている、がん細胞特異的抗ポドプラニン抗体又はその抗原結合フラグメントを提供する。
Also published as
EP2017904317
Latest bibliographic data on file with the International Bureau