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1. WO2017209121 - PROTEIN AGGREGATION INHIBITOR

Publication Number WO/2017/209121
Publication Date 07.12.2017
International Application No. PCT/JP2017/020075
International Filing Date 30.05.2017
IPC
C12N 9/96 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
C12N 9/26 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
24acting on glycosyl compounds (3.2)
26acting on alpha-1, 4-glucosidic bonds, e.g. hyaluronidase, invertase, amylase
CPC
C08F 265/06
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
265Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
04on to polymers of esters
06Polymerisation of acrylate or methacrylate esters on to polymers thereof
C08F 2810/20
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
2810Chemical modification of a polymer
20leading to a crosslinking, either explicitly or inherently
C08F 291/14
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
291Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
14on to sulfur-containing macromolecules
C12N 9/2462
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
24acting on glycosyl compounds (3.2)
2402hydrolysing O- and S- glycosyl compounds (3.2.1)
2462Lysozyme (3.2.1.17)
C12N 9/96
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
C12Y 302/01017
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
302Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
01017Lysozyme (3.2.1.17)
Applicants
  • 大阪有機化学工業株式会社 OSAKA ORGANIC CHEMICAL INDUSTRY LTD. [JP]/[JP]
  • 国立大学法人北陸先端科学技術大学院大学 JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY [JP]/[JP]
Inventors
  • 松村 和明 MATSUMURA, Kazuaki
  • ロビン ラジャン ROBIN, Rajan
  • 谷山 陽子 TANIYAMA, Yoko
  • 猿渡 欣幸 SARUWATARI, Yoshiyuki
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2016-10884631.05.2016JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROTEIN AGGREGATION INHIBITOR
(FR) INHIBITEUR DE L'AGRÉGATION DE PROTÉINES
(JA) タンパク質凝集防止剤
Abstract
(EN) Provided is a protein aggregation inhibitor to be used for inhibiting aggregation of protein, said protein aggregation inhibitor being characterized by comprising: a sulfobetaine polymer obtained by polymerizing a monomer component containing a sulfobetaine monomer; and a crosslinked polymer obtained by polymerizing a polymerizable polymer component containing the aforesaid sulfobetaine monomer and a crosslinkable monomer.
(FR) L'invention concerne un inhibiteur d'agrégation de protéines destiné à être utilisé pour inhiber l'agrégation de protéines, ledit inhibiteur d'agrégation de protéines étant caractérisé en ce qu'il comprend : un polymère de sulfobétaïne obtenu par polymérisation d'un composant monomère contenant un monomère de sulfobétaïne ; et un polymère réticulé obtenu par polymérisation d'un composant polymère polymérisable contenant le monomère de sulfobétaïne susmentionné et un monomère réticulable.
(JA) 本発明は、タンパク質の凝集を防止するために用いられるタンパク質凝集防止剤であって、スルホベタインモノマーを含有するモノマー成分を重合させてなるスルホベタインポリマーと、前記スルホベタインモノマーと、架橋性モノマーとを含有する重合性ポリマー成分を重合させてなる架橋ポリマーを含有することを特徴とするタンパク質凝集防止剤を提供する。
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