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1. WO2017004172 - TOTAL SYNTHESIS OF SHISHIJIMICIN A AND ANALOGS THEREOF

Publication Number WO/2017/004172
Publication Date 05.01.2017
International Application No. PCT/US2016/040047
International Filing Date 29.06.2016
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/192 (2006.01)
CPC
A61K 31/706
A61K 45/06
A61K 47/6803
A61K 47/6807
A61P 35/00
C07D 405/06
Applicants
  • WILLIAM MARSH RICE UNIVERSITY [US/US]; 6100 Main St. Houston, TX 77005, US
Inventors
  • NICOLAOU, Kyriacos, C.; US
  • LI, Ruofan; US
  • LU, Zhaoyong; US
  • SOHN, Te-Ik; US
  • WOODS, James; US
  • PITSINOS, Emmanouil, N.; US
Agents
  • LONG, S., Reid; US
Priority Data
62/186,19129.06.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TOTAL SYNTHESIS OF SHISHIJIMICIN A AND ANALOGS THEREOF
(FR) SYNTHÈSE TOTALE DE SHISHIJIMICINE A ET D'ANALOGUES DE CELLE-CI
Abstract
(EN)
In one aspect, the present disclosure provides shishijimicin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, antibody drug conjugates of the compounds are also provided.
(FR)
La présente invention concerne, dans un de ses aspects, des analogues de shishijimicine présentant la formule suivante: dans laquelle les variables sont telles que définies dans la description. Selon un autre aspect, la présente invention concerne également des procédés de préparation desdits composés. Selon un autre aspect encore, la présente invention concerne des compositions pharmaceutiques et des méthodes d'utilisation desdits composés. En outre, la présente invention concerne des conjugués anticorps-médicament de ces composés.
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