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1. KR1020220075317 - 약학적 화합물

Office
Republic of Korea
Application Number 1020227009222
Application Date 20.08.2020
Publication Number 1020220075317
Publication Date 08.06.2022
Publication Kind A
IPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants 리바이럴 리미티드
Inventors 코커릴 조지 스튜어트
굿 제임스
에이버리 크레이그 알렉스
코크란 에드워드 제임스
워너 앤드류 조셉
Agents 리앤목특허법인
Priority Data 1911944.5 20.08.2019 GB
Title
(KO) 약학적 화합물
Abstract
(KO) 하기 화학식 (I)의 벤조디아제핀 유도체 및 이의 약학적으로 허용 가능한 염은 RSV의 억제제이고, 그러므로 RSV 감염을 치료 또는 예방하는데 사용될 수 있다: 상기에서: 각 R 및 R는 독립적으로 H 또는 할로이고; (i) T는 N이고, Z는 C이며, 및 는 결합이고, 및 는 부재하거나; 또는 (ii) T는 C이고, Z는 N이며, 및 는 결합이고, 및 는 부재하며; 각 R 및 R는 독립적으로 할로, -OR, -NRR, -COR, -C(O)OR, -CON(R) 또는 -R이고; R는 H 또는 할로이며; 각 R 및 R은 독립적으로 H, 또는 C-C 알킬, C-C 사이클로알킬, C-C 아릴, 4- 내지 10-원 헤테로사이클릴 및 4- 내지 10-원 헤테로아릴로부터 선택되는 기이고, 상기 기는 비치환되거나 또는 치환되며; R은 H 또는 C-C 알킬이고, 각 R은 2개가 존재하는 경우 동일하거나 또는 상이하며; n은 0 또는 1이고; V, W, X 및 Y 중 하나는 N 또는 CH이고, 다른 3개는 CH이다. JPEG pct00223.jpg 57 86 1 2 JPEG pct00224.jpg 4 13 JPEG pct00225.jpg 4 13 JPEG pct00226.jpg 5 13 JPEG pct00227.jpg 4 13 JPEG pct00228.jpg 5 13 JPEG pct00229.jpg 4 13 JPEG pct00230.jpg 4 13 JPEG pct00231.jpg 4 13 3 4 6 6 7 8 8 8 2 6 5 6 7 1 6 3 10 6 10 8 1 6 8
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