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1. IN202217009919 - PHARMACEUTICAL COMPOUNDS

Office
India
Application Number 202217009919
Application Date 24.02.2022
Publication Number 202217009919
Publication Date 22.04.2022
Publication Kind A
IPC
C07D
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
A61K
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Applicants REVIRAL LIMITED
Inventors COCKERILL, George Stuart
GOOD, James
AVERY, Craig Alex
COCHRANE, Edward James
WARNER, Andrew Joseph
Priority Data 1911944.5 20.08.2019 UK
Title
(EN) PHARMACEUTICAL COMPOUNDS
Abstract
(EN) Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, ---a--- and --­c--- are bonds, and ---b--- and ---d--- are absent; or (ii) T is C, Z is N, ---b--- and ---d--- are bonds, and ---a--- and ---c--- are absent; each of R3 and R4 is independently halo, -OR6, -NR6R7, -COR8, -C(O)OR8, -CON(R8)2 or -R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
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