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1. EP3752131 - CONTINUOUS PROCESS FOR COATING LIPOSOMIAL VECTORS WITH POLYMER

Office
European Patent Office
Application Number 19710504
Application Date 12.02.2019
Publication Number 3752131
Publication Date 23.12.2020
Publication Kind B1
IPC
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
B01F 13/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of dissimilar mixers
CPC
A61K 9/1271
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
A61K 9/1277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1277Processes for preparing; Proliposomes
A61K 47/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Applicants ENG4LIFE S R L
Inventors BARBA ANNA ANGELA
LAMBERTI GAETANO
D'AMORE MATTEO
BOCHICCHIO SABRINA
DALMORO ANNALISA
Designated States
Title
(DE) KONTINUIERLICHES VERFAHREN ZUR BESCHICHTUNG VON LIPOSOMALEN VEKTOREN MIT POLYMER
(EN) CONTINUOUS PROCESS FOR COATING LIPOSOMIAL VECTORS WITH POLYMER
(FR) PROCÉDÉ CONTINU DE REVÊTEMENT DE VECTEURS LIPOSOMIAUX PAR UN POLYMÈRE
Abstract
(EN) The invention relates to a continuous or semi-continuous, and therefore rapid and highly productive, process for obtaining nanoliposomes completely coated with chitosan, a biocompatible natural polymer able to increase their stability and mucoadhesive properties. The process uses a highly productive "simil-microfluidic" technique for the polymeric coating of nano-vectors. The invention also relates to the chitosan-coated nanoliposomes or nanostructures which may be obtained through the concerned process, as well as to pharmaceutical, nutraceutical, cosmetic, personal hygiene, food or coloring products containing them.
(FR) L'invention concerne un procédé continu ou semi-continu, donc rapide et hautement productif, permettant d'obtenir des nanoliposomes complètement revêtus de chitosane, un polymère naturel biocompatible pouvant augmenter leur stabilité et leurs propriétés muco-adhésives. Le procédé met en œuvre une technique « simili-microfluidique » hautement productive pour le revêtement polymérique de nano-vecteurs. L'invention concerne également les nanoliposomes ou nanostructures revêtus de chitosane qui peuvent être obtenus au moyen du procédé concerné, ainsi que des produits pharmaceutiques, nutraceutiques, cosmétiques, alimentaires, d'hygiène personnelle ou de coloration les contenant.
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