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1. CN114555604 - Pharmaceutical compounds

Office
China
Application Number 202080072206.9
Application Date 20.08.2020
Publication Number 114555604
Publication Date 27.05.2022
Publication Kind A
IPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 31/5513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
55131,4-Benzodiazepines, e.g. diazepam
A61K 31/5377
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 31/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
A61K 31/5513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
55131,4-Benzodiazepines, e.g. diazepam ; or clozapine
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants RUYI CO., LTD.
瑞威有限公司
Inventors COCKERILL GREGORY SCOTT
G·S·科克里尔
GOODE JOHN
J·古德
AVERY, CHRISTOPHER, A.
C·A·艾弗里
COCHRAN, EDWARD, J.
E·J·科克伦
WARNER ANDREW JAMES
A·J·华纳
Agents 北京纪凯知识产权代理有限公司 11245
Priority Data 1911944.5 20.08.2019 GB
Title
(EN) Pharmaceutical compounds
(ZH) 药物化合物
Abstract
(EN) Benzodiazepine derivatives of formula (I): wherein: each of R1 and R2 is independently H or a halogen group; (i) T is N, Z is C, and is a bond, and and is not present; or (ii) T is C, Z is N, and is a bond, and both are absent; each of R3 and R4 is independently a halogen group,-OR6,-NR6R7,-COR8,-C (O) OR8,-CON (R8) 2, or-R6; r5 is H or a halogen group; each of R6 and R7 is independently H or a group selected from the group consisting of a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C6-C10 aryl group, a 4-to 10-membered heterocyclyl group, and a 4-to 10-membered heteroaryl group, said groups being unsubstituted or substituted; r8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and each of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and thus can be used in the treatment or prevention of RSV infection.
(ZH) 式(I)的苯并二氮杂衍生物:其中:R1和R2中的每个独立地是H或卤基;(i)T是N,Z是C,和是键,并且和不存在;或(ii)T是C,Z是N,和是键,并且和不存在;R3和R4中的每个独立地是卤基、‑OR6、‑NR6R7、‑COR8、‑C(O)OR8、‑CON(R8)2或‑R6;R5是H或卤基;R6和R7中的每个独立地是H或选自以下的基团:C1‑C6烷基、C3‑C10环烷基、C6‑C10芳基、4‑至10‑元杂环基和4‑至10‑元杂芳基,所述基团未被取代或被取代;R8是H或C1‑C6烷基,当存在两个时每个R8相同或不同;n是0或1;并且V、W、X和Y中的每个是N或CH并且另外三个是CH;并且其药学上可接受的盐是RSV的抑制剂并因此可以用于治疗或预防RSV感染。
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